Circulating 25-hydroxyvitamin D and risk of lung cancer: a dose-response meta-analysis.
Cancer Causes Control. 2015 Sep 10. [Epub ahead of print]
Chen GC1, Zhang ZL2, Wan Z1, Wang L3, Weber P4, Eggersdorfer M4, Qin LQ5, Zhang W6.
1 Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Renai Road, Suzhou, 215123, China.
2 Department of Labor Hygiene and Environmental Health, School of Public Health, Soochow University, Suzhou, China.
3 Special Procurement Ward, The First Affiliated Hospital of Soochow University, Suzhou, China.
4 DSM Nutritional Products Ltd., Human Nutrition and Health, Kaiseraugst, Switzerland.
5 Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Renai Road, Suzhou, 215123, China. qinliqiang at suda.edu.cn.
6 DSM Nutritional Products Ltd., Human Nutrition and Health, No. 9 Dongdaqiao Road, Beijing, 100020, China. Wei-Guo.Zhang at dsm.com.
2,227 lung cancer events
Lung Cancer risk decreases 5 % for every 2.5 ng more Vitamin D
Greatest risk reduction with Vitamin D in the range 21 to 36 nanograms
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has the following chart
Mounting experimental evidence supports a protective effect of high 25-hydroxyvitamin D (25[OH]D), a good indicator of vitamin D status, on risk of various cancers including lung cancer. However, prospective observational studies examining the 25(OH)D-lung cancer association reported inconsistent findings. A dose-response meta-analysis was carried out to elucidate the subject.
Potentially eligible studies were identified by searching PubMed and EMBASE databases, and by carefully reviewing the bibliographies of retrieved publications. The summary relative risks (RRs) with 95 % confidence intervals (CIs) were calculated using the random-effects model.
Thirteen reports from ten prospective studies were included, totaling 2,227 lung cancer events. Results of the meta-analysis showed a significant 5 % (RR 0.95, 95 % CI 0.91-0.99) reduction in the risk of lung cancer for each 10 nmol/L increment in 25(OH)D concentrations. This inverse association was not significantly modified by area, study duration, sex, methods for 25(OH)D measurement, baseline 25(OH)D levels, or quality score of included studies. There was evidence of a nonlinear relationship between 25(OH)D and risk of lung cancer (p-nonlinearity = 0.02), with the greatest reductions in risk observed at 25(OH)D of nearly 53 nmol/L, and remained protective until approximately 90 nmol/L. Further increases showed no significant association with cancer risk, but scanty data were included in the analyses of high-level 25(OH)D. There was no evidence of publication bias.
This dose-response meta-analysis of prospective studies suggests that 25(OH)D may be associated with reduced risk of lung cancer, in particular among subjects with vitamin D deficiencies.
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