Effect of serum 25-hydroxyvitamin D level on lung, breast, colorectal and prostate cancers: a nested case-control study
East Mediterr Health J. 2020 Jul 23;26(7):794-802. doi: 10.26719/emhj.20.035.
Ayla Acikgoz 1, Dilek Cimrin 2, Gul Ergor 1
Items in both categories Lung Cancer and Meta-analysis are listed here:
- Lung Cancer death 40 percent less likely if high level of Vitamin D – meta-analysis Nov 2020
- Lung Cancer more likely if poor Vitamin D Receptor – meta-analysis June 2019
- Lung Cancer risk decreased 2.4 percent with every 100 IU Vitamin D extra intake – meta-analysis Sept 2018
- Lung Cancer patients were 2.4 times more likely to have a poor Vitamin D Receptor gene – July 2017
- Lung Cancer death 60 percent less likely if high level of vitamin D – 2 meta-analysis 2017
- Lung Cancer risk decreases 5 percent for every 2.5 nanogram increase in Vitamin D – meta-analysis Sept 2015
- Lung Cancer less likely if vitamin D (higher level or supplement) – meta-analysis May 2015
Background: Published studies show that vitamin D deficiency is widespread and it has been suggested that it increases the risk of lung, breast, colorectal and prostate cancers.
Aims: To investigate prospectively the effect of serum 25-hydroxyvitamin D (25(OH)D) level on lung, breast, colorectal and prostate cancers in people aged 30+ years.
Methods: In this nested case-control study, the data and collected serum samples from a cohort study, the Balçova Heart Study, during 2007-09, were used. Additional data were collected using a questionnaire in the follow-up. We determined incident lung, breast, colorectal and prostate cancer cases during 2008 and 2013. Serum 25(OH)D levels of 606 persons (179 cases and 427 controls) from the Balçova Heart Study were measured. Odds ratio (OR) and 95% confidence interval (CI) were calculated using logistic regression analysis.
Results: Serum 25(OH)D levels did not show a significant association with breast, colorectal and prostate cancers.
There was an inverse association between 25(OH)D level and lung cancer risk, where the OR values for the first, second and third quartiles, compared with the fourth quartile (1.00), were
- 2.92 (CI: 0.82-10.35),
- 3.76 (CI: 1.14-12.37) and
- 3.55 (CI: 1.04- 12.08) respectively.
Conclusion: It was seen that low 25(OH)D levels were associated with a greater than threefold increased risk of lung cancer; no association was detected for breast, colorectal and prostate cancers. Cohort studies with larger populations are needed to better understand the effect of vitamin D level on cancer risk.