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Kidney cancer 22 percent less likely if high vitamin D – meta-analysis Nov 2015

Examining the association of circulating 25-hydroxyvitamin D with kidney cancer risk: a meta-analysis

Int J Clin Exp Med. 2015; 8(11): 20499–20507. Published online 2015 Nov 15, PMCID: PMC4723811
Guangzheng Lin,1,* Ling Ning,2,* Di Gu,1,* Shi Li,1 Zhe Yu,1 Qicheng Long,1 Li-Na Hou,3 and Wan-Long Tan1



  1. No indication of how many years elapsed (if any) between Vitamin D test and kidney cancer diagnosis
  2. No indication if kidney was failing before kidney cancer, and thus not producing active vitamin D needed to fight cancer
  3. All studies “corrected” for smoking and BMI status.
    But recall that both greatly reduces vitamin D levels. Wonder how they made their “correction”
  4. All studies ignored the effect of genes - a 5X effect - see below

Suspect vitamin D actual protection against Kidney Cancer is actually much higher – perhaps similar to 10+ other cancers: > 60%, not just 22%, especially if use a form of Vitamin D which does not require Kidney activation

See also VitaminDWiki

Many ways to increase Vitamin D
such as Calcitriol, Omega-3, and a purple herb for Kidney problems
click on chart for details

Huge decrease in cancers as increase vitamin D
derived from Grassroots 2013

 Download the PDF from VitaminDWiki


Objective: To examine the relationship between circulating 25-hydroxy-vitamin D (25 (OH) D) and risk of kidney cancer. Methods: We searched PubMed, EMBASE, and Web of Science databases through August 31, 2015 for eligible studies. Pooled ORs with 95% confidence interval were calculated using fixed effect models. All data analyses were performed with STATA version 12.0.

Results: The final analysis included 2 prospective cohort studies and 7 nested case-control studies, with a total of 130, 609 participants and 1, 815 cases of kidney cancer. No obvious heterogeneity was observed between individual studies. The results of this study revealed that higher circulating 25-hydroxyvitamin D levels were associated with lower risk of kidney cancer (OR=0.79, 95% CI 0.69-0.91; P value for heterogeneity: 0.61, I2=0%). After stratified by geographical region, the similar association was detected in European studies (OR=0.81, 95% CI 0.69-0.94; P value for heterogeneity: 0.38, I2=0%), though no significant association was observed in the USA studies (OR=0.73, 95% CI 0.51-1.04; P value for heterogeneity: 0.44, I2=0%).

Conclusion: Our present findings suggest that higher levels of circulating 25-hydroxyvitamin D could reduce the risk of kidney cancer by 21%. Further well-designed large-scaled prospective studies and randomized controlled trials are warranted to provide more conclusive evidence.

Attached files

ID Name Comment Uploaded Size Downloads
6507 KC meta.jpg admin 30 Mar, 2016 143.55 Kb 1275
6506 Kidney Cancer Meta.pdf admin 30 Mar, 2016 517.38 Kb 781