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Hypothesis - Atopic Dermatitis protected by Omega-3 - Aug 2015

Do long-chain omega-3 fatty acids protect from atopic dermatitis?

Journal der Deutschen Dermatologischen Gesellschaft. Volume 13, Issue 9, pages 879–885, September 2015,DOI: 10.1111/ddg.12780
Imke Reese1,* andThomas Werfel2

Long-chain polyunsaturated fatty acids are essential for human nutrition. The number of double bonds determines whether a given fatty acid is termed two, three, or x times unsaturated. Depending on the distance of the first double bond from the fatty acid's methyl group, one distinguishes omega-3 fatty acids from omega-6 fatty acids.

While the use of gamma linolenic acid, a long-chain fatty acid of the omega-6 family, has proven unsuccessful in the prevention or treatment of atopic dermatitis, supplementation of long-chain omega-3 fatty acids may represent a promising approach in the prevention of allergic disorders, especially atopic dermatitis. Whether the concept of long-chain omega-3 fatty acid administration will also become established in a therapeutic setting, depends on whether the beneficial effects observed so far can be substantiated in randomized controlled intervention studies.

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