Health problems that run in families are often associated with low vitamin D

"A particular disorder might be described as “running in a family” if more than one person in the family has the condition. Some disorders that affect multiple family members are caused by gene mutations, which can be inherited (passed down from parent to child)." Google

VitaminDWiki realization

• If a single disease runs in the family it is possible that it is due to a vitamin D gene problem
• If multiple diseases occur in the family is it likely that they are due to a vitamin D gene problem

Every single health problem in this list is strongly related to vitamin D deficiency.

I have noticed that many of the health problems prevented/treated by vitamin D seem to run in families.
Here is the first list which I found in Google on family related diseases from The National Institute of Health (US).

Health problem that runs in family	VitaminDWiki
alzheimer's/dementia	Alzheimers
arthritis	Rheumatoid Arthritis
asthma	Asthma
blood clots	Blood clotting
cancer	Cancer
depression	Depression
diabetes	Diabetes
heart disease	Cardiovascular
high cholesterol	Cholesterol
high blood pressure	Hypertension
pregnancy losses & birth defects	Pregnancy
stroke	Stroke

Genes can make the body less efficient at getting vitamin D to the cells.

• 2 genes have effects which CAN be detected by vitamin D blood tests.
• 4 genes have effects which CANNOT be detected by vitamin D blood tests.
• In either case, if a vitamin D deficiency disease runs in your family you will need more vitamin D than the general population.
  Depending on the gene and the disease, you will need 10% to perhaps 200% larger dose of vitamin D to cancel the gene problem.
  Unknowns
  How much more if one specific health problem runs in the family
  How much more vitamin D if several health problems run in the family

Gene studies in VitaminDWiki

• Benefits of Vitamin D often limited by genes
• Some of Us May Need More Vitamin D Than Others - Sept 2015
  includes information on various genetic testing and add-on services
• Common Vitamin D gene variants and resulting diseases – Jan 2013
• Genes (CYP2R1 and GC) which restrict the amount of Vitamin D which gets into bloodstream – June 2014
• Increased mortality associated with low vitamin D genes – Nov 2014
• Many autoimmune diseases associated with latitude and vitamin D receptor – March 2016
• Role of Vitamin D in human Diseases and Disorders – An Overview – DBP, VDR June 2014
• Blood tests can be a poor measure of actual vitamin D due to D Binding Protein (DBP) – May 2014
• Genes and Vitamin D 342 items
• Vitamin D Binding Protein 177 items

Vitamin D Receptor

523 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells

See also: 48 studies in the Resveratrol category

It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems

Health problems include: Autoimmune (19 studies), Breast Cancer (23 studies), Colon Cancer (13 studies), Cardiovascular (23 studies), Cognition (16 studies), Diabetes (24 studies), Hypertension (9 studies), Infant (22 studies), Lupus (6 studies), Metabolic Syndrome (4 studies), Mortality (4 studies), Multiple Sclerosis (12 studies), Obesity (17 studies), Pregnancy (24 studies), Rheumatoid Arthritis (10 studies), TB (8 studies), VIRUS (36 studies),   Click here for details
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation

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55 health problems associated with poor VDR

A poor VDR is associated with the risk of 55 health problems  click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023  click here for details
Some health problem, such as Breast Cancer reduce the VDR

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

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How to increase VDR activation

Compensate for poor VDR by increasing one or more:

Increasing	Increases
1) Vitamin D supplement  Sun Ultraviolet -B	Vitamin D in the blood and thus in the cells
2) Magnesium	Vitamin D in the blood  AND in the cells
3) Omega-3	Vitamin D in the cells
4) Resveratrol	Vitamin D Receptor
5) Intense exercise	Vitamin D Receptor
6) Get prescription for VDR activator    paricalcitol, maxacalcitol?	Vitamin D Receptor
7) Quercetin (flavonoid)	Vitamin D Receptor
8) Zinc is in the VDR	Vitamin D Receptor
9) Boron	Vitamin D Receptor ?, etc
10) Essential oils e.g. ginger, curcumin	Vitamin D Receptor
11) Progesterone	Vitamin D Receptor
12) Infrequent high concentration Vitamin D Increases the concentration gradient	Vitamin D Receptor
13) Sulfroaphane and perhaps sulfur	Vitamin D Receptor
14) Butyrate especially gut	Vitamin D Receptor
15) Berberine	Vitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR

Gene studies of health problems which run in families

• Alzheimer’s Alzheimer’s Disease is associated with genes which restrict vitamin D – Aug 2015
• Rheumatoid arthritis Rheumatoid arthritis is 40 percent more likely if vitamin D Receptor problem – 2 meta-analyses 2015
• Asthma 2X higher risk of wheezing and asthma if modified receptor genes, even if vitamin D levels OK – Sept 2015
• Asthma Strong Vitamin D deficiency associations in Asthma patients – Nov 2014
• Cancers Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014
• Cancer - Breast Breast Cancer rate reduced 72 percent by vitamin D gene polymorphism CYP24A1 – Nov 2014
• Cancer - Bladder Poor Bladder Cancer survival associated with poor Vitamin D receptor – Oct 2015
• Cancer - Colon Colon cancer 30 percent more likely if problems with Vitamin D genes CYP24A1 or CYP27B1 – Nov 2015
• Cancer - Pancreatic Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1 – July 2014
• Cancer - Melanoma Melanoma risk 2X to 4X higher if Vitamin D receptor genes had morphed – March 2014
• Cardiovascular Potential for vitamin D receptor agonists in the treatment of cardiovascular disease
• T2 Diabetes Vitamin D receptor gene associated with 50 percent more type 2 Diabetes – meta-analyses 2013, 2016
• T1 Diabetes Type 1 diabetes associated with faulty Vitamin D receptor genes – May 2013
• Hypertension Hypertension associated with genes which reduce vitamin D – meta-analysis June 2014
• Lupus If Lupus in family – 5 times more likely to get Lupus if low vitamin D and poor CYP24A1 – June 2016
• Stroke Ischemic Stroke 3X more likely if Vitamin D Receptor gene change (Fok 1) – Jan 2014

Gene studies of other health problems in VitaminDWiki

• Lungs with cystic fibrosis fail to activate vitamin D (poor CYP27B) – Feb 2016
• Crohn's disease associated with 7.6X deactivation of Vitamin D receptor – July 2015
• Genes make Multiple Sclerosis 2X more likely unless get more vitamin D - Aug 2015
• 2X more Parkinson's disease if modified vitamin D receptor genes – meta-analysis Aug 2014
• Multiple Sclerosis patients need more vitamin D to get same blood level response – Aug 2015
• Gene makes COPD 2.6X more likely unless get more vitamin D – meta-analysis Dec 2014
• Obesity strongly associated with vitamin D receptor in Saudia Arabia – July 2014
• Osteoporosis 2.8 X more likely if Vitamin D receptor (VDR) genes altered – Aug 2013
• Food allergy 12X more likely if low vitamin D and vitamin D binding gene problem – Aug 2015
• 2 Genes make AMD 6X more likely if low vitamin D - Aug 2015 Age related Macular Degeneration
• Tuberculosis, Genes, Vitamin D Binding Protein, and RCT – Review Aug 2014
• Hip Fracture 2.5 times more likely if poor Vitamin D Binding Protein gene - Aug 2015

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Also associated with many of the same diseases: Magnesium, Omega-3

Magnesium    Omega-3
The items in both categories of Magnesium and Omega:

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See also heritability on VitaminDWiki

• Majority of heritable diseases are associated with vitamin D (from 4 million health records) – July 2016
• Vitamin D insufficiency in child 15X more likely if father is Vitamin D insufficient – June 2021
• Vitamin D Heritability: twin studies – 20 percent to 85 percent, GWAS 5 percent – Oct 2018
• Does survival of the less fit mean less health (poor genes may be inherited)

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Studies which are in both the GENE and Disease categories

Rheumatoid Arthritis

Cancer (not specific cancer category)

Diabetes

Cardiovascular

Hypertension

Pregnancy

Stroke

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Studies which are in both the Vitamin D Receptor and Disease categories

Rheumatoid Arthritis

Cancer (not specific cancer category)

Diabetes

Cardiovascular

Hypertension

Pregnancy

Stroke

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See also web

• Diseases that run in families not all down to genes, study shows July 2016
  ". . examined the medical histories of more than 500,000 people and their families — including both blood and adoptive relatives."
  . .They looked at incidents of 12 common diseases including high blood pressure, heart disease, and several cancers and neurological diseases."
  "By not accounting for shared environmental factors, scientists may overestimate the importance of genetic variation by an average of 47 per cent, the study found"
• Fact Sheet: Family History is Important for Health CDC Key Features Dec 2015
  Diseases that occur at an earlier age than expected (10 to 20 years before most people get the disease);
  Disease in more than one close relative;
  Disease that does not usually affect a certain gender (for example, breast cancer in a male);
  Certain combinations of diseases within a family (for example, breast and ovarian cancer, or heart disease and diabetes).
• Have You Inherited a Vitamin D Deficiency?
  Jan 2016 Susan Rex Ryan

Autoimmune Disease Clusters - which run in families

• Video by Dr. Coimbra – 95 percent of auto-immune cured with vitamin D in high doses - April 2014
• Do Autoimmune Diseases Run in Families? HealthCentral 2013
  " . . autoimmune diseases which tend to cluster (aggregate) in our families."
  "Familial autoimmunity was investigated in five major autoimmune diseases: rheumatoid arthritis, systemic lupus erythematosus, autoimmune thyroid disease, multiple sclerosis, and type 1 diabetes mellitus. "
  Example: familial autoimmunity in Graves’ disease 14 X more likely to have family members to have pernicious anemia or RA

How do autoimmune diseases cluster in families? A systematic review and meta-analysis - 2013
 Download the PDF from VitaminDWiki

Figure 8 Familial autoimmunity. The vertical axis corresponds to the proband’s disease and each disease individually. In the horizontal axis diseases present in first degree relatives are shown. Each color belongs to the proband’s disease. The figure only includes significant results and may serve as a guide for clinical practice in order to search ADs in FDRs of probands. Note that familial autoimmune disease is excluded.
AA, alopecia areata; AdD, Addison’s disease; AS, ankylosing spondylitis; AITD, autoimmune thyroid disease; CD, celiac disease; CrD, Crohn’s disease; FDR, first degree relative; IBD, inflammatory bowel disease; IIM, idiopathic inflammatory myositis; JDM, juvenile dermatomyositis; JRA, juvenilerheumatoid arthritis; JSLE, juvenile systemic lupus erythematosus; MAS, multiple autoimmune syndrome; MG, myasthenia gravis; MS, multiple sclerosis; PA, pernicious anemia; PAN, polyarteritis nodosa; PBC, primary biliary cirrhosis; PSO, psoriasis; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; SS, Sjögren’s syndrome; SSc, systemic sclerosis; T1D, type 1 diabetes; UC, ulcerative colitis; VIT, vitiligo; WG, Wegener’s granulomatosis.

This study was cited by 57 other publications in Google Scholar as of July 2016 such as:

• Hashimoto thyroiditis: clinical and diagnostic criteria
• Diagnosis and classification of autoimmune diabetes mellitus
• Pathogenesis and prevention of rheumatic disease: focus on preclinical RA and SLE
• Systemic sclerosis at the crossroad of polyautoimmunity
• New insights into an autoimmune mechanism, pharmacological treatment and relationship between multiple sclerosis and inflammatory bowel disease
• The diagnosis and clinical significance of polyautoimmunity
• Is narcolepsy a classical autoimmune disease?
• Associated autoimmune diseases in children and adolescents with type 1 diabetes mellitus (T1DM)
• Identification of a new disease cluster of pemphigus vulgaris with autoimmune thyroid disease, rheumatoid arthritis, and type I diabetes

More on this topic at Autoimmune disease clusters run in families (polyautoimmunity) are associated with low vitamin D