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COVID-19 was 2.6X more severe if very low Vitamin D (43 studies) – meta-analysis March 26, 2021

Therapeutic and prognostic role of vitamin D for COVID-19 infection: A systematic review and meta-analysis of 43 observational studies

The Journal of Steroid Biochemistry and Molecular Biology, https://doi.org/10.1016/j.jsbmb.2021.105883
Fausto Petrellia faupe at libero.IT, Andrea Luciania Gianluca Peregob Giuseppina Dogninic Paolo Luigi Colombellic Antonio Ghidinid

VitaminDWiki

This study assumed that vitamin D for bone health should be applied to COVID-19 (< 20ng)
The human body needs different levels of vitamin D to fight different health problems
For example, need 50 ng to fight Infections
Human bodies appear to need at least 40 ng to fight COVID-19
The study mentions that vitamin D supplementation
   (for any dose size, any duration), reduced risk of severe COVID-19 by 3.7 X


This study was the 10th Vitamin D and COVID-19 meta-analysis in VitaminDWiki

COVID-19 treated by Vitamin D - studies, reports, videos

As of Sept 27, 2021, the page had:  34 trials6 trial results,   23 meta-analyses and reviews,   64 observations,   35 recommendations,   55 associations,  89 speculations,  48 videos   see related:   Governments,   HealthProblems,   Hospitals,  Dark Skins,   26 risk factors are ALL associated with low Vit D,   Recent Virus pages   Fight COVID-19 with 50K Vit D weekly   Vaccines

 Download the PDF from VitaminDWiki

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Highlights

  • Vitamin D modulates the systemic inflammatory response through interaction with immune system.
  • We systematically reviewed studies about vitamin D3 and risk and mortality for COVID-19 infection
  • Reduced vitamin D values resulted in a higher infection risk, mortality and severity COVID-19 infection.

Vitamin D modulates the systemic inflammatory response through interaction with immune system. As such, it has a possible protective role against the risk of respiratory tract infections and other diseases. It may be useful in particular, during COVID-19 pandemic. PubMed, the Cochrane Library, and EMBASE were searched from inception until January 31, 2021, for observational or clinical studies reporting the prognosis (and therapeutic effect) of COVID-19 infection in patients with deficient vitamin D levels. The infection rate, severity, and death from COVID-19 infection were pooled to provide an odds ratio with a 95% confidence interval (OR 95% CI). An OR > 1 was associated with the worst outcome in deficient compared with nondeficient patients.

We assessed the association between vitamin D and risk, severity, and mortality for COVID-19 infection, through a review of 43 observational studies. Among subjects with deficient vitamin D values, risk of COVID-19 infection was higher compared to those with replete values (OR = 1.26; 95% CI, 1.19-1.34; P < .01). Vitamin D deficiency was also associated with worse severity and higher mortality than in nondeficient patients (OR = 2.6; 95% CI, 1.84-3.67; P <  .01 and OR = 1.22; 95% CI, 1.04-1.43; P <  .01, respectively).

Reduced vitamin D values resulted in a higher infection risk, mortality and severity COVID-19 infection. Supplementation may be considered as preventive and therapeutic measure.


Created by admin. Last Modification: Friday June 25, 2021 14:48:34 GMT-0000 by admin. (Version 10)

Attached files

ID Name Comment Uploaded Size Downloads
15390 Meta 43.pdf PDF 2021 admin 07 Apr, 2021 19:09 947.46 Kb 72
15331 Meta observations.jpg admin 27 Mar, 2021 13:42 54.19 Kb 252
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