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Benefits of Omega-3 plus Vitamin D were additive – RCT Sept 2021

Effect of omega-3 and vitamin D co-supplementation on psychological distress in reproductive-aged women with pre-diabetes and hypovitaminosis D: A randomized controlled trial

Brain and Behaviour https://doi.org/10.1002/brb3.2342
Masoumeh Rajabi-Naeeni,Mahrokh Dolatian,Mostafa Qorbani,Amir Abbas Vaezi,

Summary article by GrassrootsHealth

2 + 2 = 4
Expect to find that vitamin D is al least synergistic with Omega-3 for many health problems

Omega-3 and Vitamin D each treat many mental health problems - April 2018

Anticipate finding other synergistic combinations, such as:
Vitamin D + (Resveratrol or Curcumin or Querctin or Zinc)
Vitamin D + Magnesium
Vitamin D + Iron
Vitamin D + Vitamin K2

Psychological distresses and pre-diabetes are among the risk factors of developing type-II diabetes. The present study was conducted to determine the effectiveness of omega-3 and vitamin D co-supplementation on psychological distresses in women of reproductive age with pre-diabetes and hypovitaminosis D.

The present factorial clinical trial was conducted on 168 women of reproductive age with pre-diabetes and hypovitaminosis D. These participants were selected by stratified random sampling and were assigned to four groups for 8 weeks: group 1 (placebo group), group 2 (omega-3 group), group 3 (vitamin D group), and group 4 (co-supplement group). The medication and placebo doses being two 1000-mg tablets each day for omega-3 and 50,000-IU pearls every 2 weeks for vitamin D. Fasting blood glucose and vitamin D were measured at the beginning of the study. The Depression Anxiety Stress Scale-21 and the Pittsburgh Sleep Quality Index were completed by the participants at the start and end of the intervention.

A significant difference was observed in terms of reduction in anxiety and improvement in sleep quality in the co-supplementation compared to the other three groups (p < .05). There was also a significant difference between the group receiving both supplements and the group receiving only placebos in terms of reduction in depression and stress (p < .05).

Vitamin D and omega-3 co-supplementation improved depression, anxiety, and sleep quality in women of reproductive age with pre-diabetes and hypovitaminosis D. Therefore, these two supplements can be recommended for improving the mental health of this group of women.

Clinical trial registry
Iranian Registry of Clinical Trials Code: IRCT20100130003226N17. Registered on February 9, 2019.
 Download the PDF from VitaminDWiki

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VitaminDwiki - Sleep category starts with

94 items in sleep category

A few items in SLEEP category

Sleep and Omega-3:

11+ items with Anxiety in the title

This list is automatically updated

Items found: 12

VitaminDwiki - Vitamin D and Omega-3 category contains

379 Omega-3 items in category Omega-3 helps with: Autism (9 studies), Depression (29 studies), Cardiovascular (32 studies), Cognition (48 studies), Pregnancy (39 studies), Infant (31 studies), Obesity (13 studies), Mortality (5 studies), Breast Cancer (5 studies), Smoking, Sleep, Stroke, Longevity, Trauma (12 studies), Inflammation (18 studies), Multiple Sclerosis (9 studies), VIRUS (12 studies), etc
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Attached files

ID Name Comment Uploaded Size Downloads
16293 O3 D adi d additive.jpg admin 27 Sep, 2021 10:39 116.21 Kb 349
16292 Omeg-3 and Vitamin D additive.pdf PDF 2021 admin 27 Sep, 2021 10:39 286.21 Kb 149