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Alzheimer’s Disease risk is 1.3X higher if Vitamin D deficient – meta-analysis Nov 2019

Vitamin D deficiency as a risk factor for dementia and Alzheimer’s disease: an updated meta-analysis

BMC Neurology volume 19, Article number: 284 (2019) Cite this article
Bingyan Chai, Fulin Gao, Ruipeng Wu, Tong Dong, Cheng Gu, Qiaoran Lin & Yi Zhang


Items of Cognition and Meta-analysis

Alzheimer's and Vitamin D Genes

Alzheimer's and Vitamin D Cofactors

Overview Alzheimer's-Cognition and Vitamin D starts with

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GrassrootsHealth plot of the data

We aimed to comprehensively explore the associations between serum 25(OH)D deficiency and risk of dementia and Alzheimer’s disease(AD).

We systematically searched Pubmed, the Cochrane Library, Embase and the reference lists of pertinent review articles for relevant articles published from database inception up until January 2019. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with random effects models using the Stata 12.0 statistical software package.

Twelve prospective cohort studies and four cross-sectional studies were included in this meta-analysis. The pooled HRs of dementia and AD, respectively, were 1.32 (95%CI: 1.16, 1.52) and 1.34 (95%CI: 1.13, 1.60) for vitamin D deficiency (< 20 ng/ml).
In the subgroup analyses, the pooled HRs of dementia and AD, respectively, were 1.48 (95%CI: 1.19, 1.85) and 1.51 (95%CI: 1.04, 2.18) for moderate vitamin D deficiency (10–20 ng/ml) and 1.20 (95%CI: 0.99, 1.44) and 1.36 (95%CI: 1.01, 1.84) for severe vitamin D deficiency (< 10 ng/ml).

There are significant associations between vitamin D deficiency and both dementia and AD. There are stronger associations between severe vitamin D deficiency (< 10 ng/ml) and both dementia and AD compared to moderate vitamin D deficiency (10–20 ng/ml).

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14158 Chai GRH.jpg admin 10 Aug, 2020 64.90 Kb 277
12986 Alz.jpg admin 16 Nov, 2019 51.48 Kb 454
12985 Alz Meta 2019.pdf admin 16 Nov, 2019 984.97 Kb 568