Study on the Improvement of Behavioral and Cognitive Dysfunction of Children with OSAHS by Vitamin D
Biomed Res Int . 2021 May 7;2021:5536689. doi: 10.1155/2021/5536689. eCollection 2021.
Panpan Cui 1, Lei Ge 2, Jiansheng Li 1
- Tiny amount of fully activated Vitamin D does treat psoriasis – Jan 2020
- Risk of sleep apnea in obese increases 3.4X with poor vitamin D Receptor – Sept 2021
- Obstructive sleep apnea, CPAP, and COVID-19 (Vitamin D can probably help) – Review Feb 2021
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- The worse the sleep apnea, the lower the vitamin D levels – meta-analysis 2017, 2020
- Poor sleep associated with low vitamin D (again) – July 2017
- Sleep Apnea patients – 98 percent had low vitamin D – Feb 2016
- The Better Sleep Vitamin (Vitamin D) – nice 3 dollar book Feb 2015
- CDC listed health problems at increased risk of COVID-19 (all are associated with low Vitamin D) - Dec 1, 2020
Sleep category starts with
A few items in SLEEP category
- Sleep greatly improved by 50,000 IU of vitamin D once every two weeks – RCT Sept 2018
- Sleeps disorders nicely treated by Vitamin D (50,000 IU twice a month) – RCT May 2017
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- On the job sleepiness 2.2X more likely if low vitamin D – Feb 2020
- Poor sleep 1.5 X more likely if less than 20 ng of Vitamin D – Feb 2019
- The Better Sleep Vitamin (Vitamin D) – nice 3 dollar book Feb 2015
- The worse the sleep apnea, the lower the vitamin D levels – meta-analysis 2017, 2020
- Vitamin D for better sleep video - Dec 2021
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- Sleep Apnea and Vitamin D - many studies
- Melatonin and Vitamin D - many studies does much more than improve sleep
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Objective: This study is aimed at exploring the role of vitamin D in the treatment of children with OSAHS by comparing the clinical symptoms, serum indicators, and behavioral changes of vitamin D intervention.
Method: Healthy children who were examined physically in Rizhao People's Hospital were selected as the control group, and their sex, age, triglyceride, total cholesterol, high-density lipoprotein, low-density lipoprotein, serum 25-OHD levels, and Conners' parental scale were measured. In addition, children diagnosed as OSAHS in the otolaryngology department of Rizhao People's Hospital were selected as experimental subjects. Their body mass index, triglycerides, total cholesterol, high-density lipoprotein, low-density lipoprotein, serum 25-OHD levels, sleep apnea hypopnea index, minimum oxygen saturation, and Conners' parental scale were measured. The experimental subjects were treated with Rocaltrol intervention therapy (0.25 g/QD) for 4 weeks and reanalyzing their triglycerides, total cholesterol, high-density lipoprotein, low-density lipoprotein, serum 25-OHD levels, sleep apnea hypopnea index, minimum oxygen saturation, and Conners' parental scale.
Result: OSAHS children commonly have the situation of obesity, dyslipidemia, and vitamin D deficiency. Behavioral and cognitive dysfunction is common in OSAHS children. There were no significant changes in body mass index, triglycerides, total cholesterol, high-density lipoprotein, low-density lipoprotein, sleep apnea, hypopnea index, and minimum oxygen saturation for OSAHS children after vitamin D treatment, but the serum 25-OHD level is significantly improved, and children with conduct problems, learning problems, and hyperactivity index decrease.
Conclusion: (1) OSAHS children commonly have the situation of obesity, dyslipidemia, vitamin D deficiency, and behavioral and cognitive impairment. (2) Vitamin D supplementation has no therapeutic effect on obesity and dyslipidemia of OSAHS children, but has obvious protective and improving effects on neuron damage caused by hypoxia. Obstructive sleep apnea syndrome (OSAHS) is a common disease. Patients with OSAHS usually have many clinical features, such as obesity, metabolic syndrome, and cardiovascular disease. The decline of cognitive function and learning ability is one of the serious complications of OSAHS patients [1]. Vitamin D (VitD) deficiency is associated with many diseases. Recent studies have shown that the serum 25-OHD level of OSAHS patients is relatively insufficient and related to the disease severity. However, there are few reports on explaining whether vitamin D supplementation can alleviate the clinical symptoms and improve serum indicators and behavioral and cognitive dysfunction in children with OSAHS.
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