The Association between 25-Hydroxyvitamin D Concentration and Disability Trajectories in Very Old Adults: The Newcastle 85+ Study
Nutrients 2020,12, 2742; doi:10.3390/nu12092742
Sarah Hakeem 1,2,3, Nuno Mendonca 1,2,4,5, Terry Aspray 6, , Andrew Kingston , CarmenRuiz-Martin CarolJagger John C.Mathers O/Rachel Duncan7 and Tom R.Hill 1,2' tom.hill at ncl.ac.uk
- Frailty and Vitamin D - many studies
- 80 percent of the characteristics of frailty associated with low vitamin D – May 2013
- Frailty 9X more likely if low vitamin D – Nov 2015
- Frailty risk increases 12 percent for every 10 ng less vitamin D – meta-analysis Sept 2018
- Majority of frail hospital patients had low vitamin D, which did not change with season – 2018
Seniors category starts with
see also
Overview Seniors and Vitamin D
Muscles and Vitamin D - many studies 125+ items
Overview Fractures and Falls and Vitamin D
Overview Alzheimer's-Cognition and Vitamin D
Overview Cancer and vitamin D
Overview Influenza and vitamin D
Overview Diabetes and vitamin D
Hearing Loss appears to be prevented and treated with vitamin D
Overview Osteoporosis and vitamin D
Restless Legs Syndrome dramatically reduced by vitamin D, etc
Overview Rheumatoid Arthritis and vitamin D
Frailty and Vitamin D - many studies many studies
Nursing homes and Vitamin D - many studies
13 reasons why many seniors need more vitamin D (both dose and level) - July 2023 has:
- Senior skin produces 4X less Vitamin D for the same sun intensity
- Seniors have fewer vitamin D receptor genes as they age
Receptors are needed to get Vitamin D in blood actually into the cells - Many other Vitamin D genes decrease with age
- Since many gene activations are not detected by a blood test,
more Vitamin D is often needed, especially by seniors - Seniors are indoors more than when they were younger
not as agile, weaker muscles; frail, no longer enjoy hot temperatures - Seniors wear more clothing outdoors than when younger
Seniors also are told to fear skin cancer & wrinkles - Seniors often take various drugs which end up reducing vitamin D
Some reductions are not detected by a vitamin D test of the blood
statins, chemotherapy, anti-depressants, blood pressure, beta-blockers, etc - Seniors often have one or more diseases that consume vitamin D
osteoporosis, diabetes, Multiple Sclerosis, Cancer, ... - Seniors generally put on weight as they age - and a heavier body requires more vitamin D
- Seniors often (40%) have fatty livers – which do not process vitamin D as well
- Reduced stomach acid means less Magnesium is available to get vitamin D into the cells
- Vitamin D is not as bioavailable in senior intestines
- Seniors with poorly functioning kidneys do not process vitamin D as well
- Glutathione (which increases Vitamin D getting to cells) decreases with age
Seniors category has430 items Download the PDF from VitaminDWiki
Model 4Background: Low vitamin D status is common in very old adults which may have adverse consequences for muscle function, a major predictor of disability. Aims: To explore the association between 25-hydroxyvitamin D [25(OH)D] concentrations and disability trajectories in very old adults and to determine whether there is an ‘adequate' 25(OH)D concentration which might protect against a faster disability trajectory.
Methodology: A total of 775 participants from the Newcastle 85+ Study for who 25(OH)D concentration at baseline was available. Serum 25(OH)D concentrations of <25 nmol/L, 25-50 nmol/L and >50 nmol/L were used as cut-offs to define low, moderate and high vitamin D status, respectively. Disability was defined as difficulty in performing 17 activities of daily living, at baseline, after 18,36 and 60 months.
Results: A three-trajectory model was derived (low-to-mild, mild-to-moderate and moderate-to-severe). In partially adjusted models, participants with 25(OH)D concentrations <25 nmol/L were more likely to have moderate and severe disability trajectories, even after adjusting for sex, living in an institution, season, cognitive status, BMI and vitamin D supplement use. However, this association disappeared after further adjustment for physical activity. Conclusions: Vitamin D status does not appear to influence the trajectories of disability in very old adults.
85 year olds who were not Vitamin D deficient had and continued to have few disabilities – Sept 2020(Cached) Printer Friendly Follow this page for updates7369 visitors, last modified 29 Nov, 2020, This page is in the following categories (# of items in each category)Attached files
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