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10,000 IU of Vitamin D taken daily for 3 years is safe – RCT Nov 2019

Safety of High-Dose Vitamin D Supplementation: Secondary Analysis of a Randomized Controlled Trial.

J Clin Endocrinol Metab. 2019 Nov 20. pii: dgz212. doi: 10.1210/clinem/dgz212.
Billington EO1, Burt LA1, Rose MS2, Davison EM1, Gaudet S1, Kan M1, Boyd SK1, Hanley DA1.
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VitaminDWiki

124 adults (age 60) in each group
Calcium was ADDED daily to achieve 1200+ mg/day
    Note: High dose groups often RESTRICT Calcium, 750 mg seems to be a good level
Response rangeg from 30 to 120 ng
Response dropped during 3rd year
    Did the genes adjust?
Very few adverse events


See also VitaminDWiki

Respond to daily Vitamin D in 2-12 months
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10,000 IU of Vitamin D for 7 years with no excessive Calcium in 4,800 patients – Dec 2018 Calcium was NOT added
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10,000 IU of Vitamin D is too much if you also take Calcium supplements – RCT Sept 2018
released Nov 30, 2010
Green diamonds = supplements actually sold
Overview Vitamin D Dose-Response
GARLAND. FRENCH . BAGGERLY. HEANEY
Huge variation in response to vitamin D supplementation – personal vitamin D response index – Dec 2016
Wide response to 3,200 IU daily
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Response to vitamin D increased 30 percent with Magnesium - Nov 2018
4,000 IU of Vitamin D is OK - 19 organizations agree - 2018
    and 6 organizations said 10,000 IU daily was OK
Reasons for low response to vitamin D includes many charts, such as:
Reductions in Vitamin D is.gd/VitDReductions

 Download the PDF from Sci-Hub via VitaminDWiki
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CONTEXT: Over 3% of adults report vitamin D intakes ≥4000 IU/day, but the safety of this practice is unknown.

OBJECTIVE: To establish whether vitamin D doses up to 10000 IU/day are safe and well-tolerated.

DESIGN: The Calgary Vitamin D Study was a three-year double-blind RCT.

SETTING: Single-centre study at the University of Calgary, Canada.

PARTICIPANTS: Healthy adults (n=373) aged 55-70 with serum 25-hydroxyvitamin D 30-125 nmol/L.

INTERVENTIONS: Participants were randomized 1:1:1 to vitamin D3 400, 40000 or 10000 IU/day. Calcium supplementation was initiated if dietary calcium intake was <1200mg/day.

MAIN OUTCOME MEASURES:
In these pre-specified secondary analyses, changes in serum 25-hydroxyvitamin D, calcium, creatinine, 24-hour urine calcium excretion, and incidence of adverse events were assessed. Between-group differences in adverse events were examined using incident rate differences and logistic regression.

RESULTS:
Of 373 participants (400:124, 4000:125, 10000:124), 49% were male, mean (SD) age was 64 (4) years, and 25-hydroxyvitamin D 78.0 (19.5) nmol/L. Serum calcium, creatinine, and 24-hour urine calcium excretion did not differ between treatments. Mild hypercalcemia (2.56-2.64 mmol/L) occurred in 15 (4%) participants (400:0%, 4000:3%, 10000:9%, p=0.002); all cases resolved on repeat testing. Hypercalciuria occurred in 87 (23%) participants (400:17%, 4000:22%, 10000:31%, p=0.011). Clinical adverse events were experienced by 365 (97.9%) participants and were balanced across treatment arms.

CONCLUSIONS:
The safety profile of vitamin D supplementation is similar for doses of 400, 4000 and 10000 IU/day. Hypercalciuria was common and occurred more frequently with higher doses. Hypercalcemia occurred more frequently with higher doses but was rare, mild, and transient.


Created by admin. Last Modification: Thursday November 21, 2019 16:27:27 GMT-0000 by admin. (Version 7)

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13023 10,000 IU safe.jpg admin 21 Nov, 2019 94.62 Kb 753
13022 10,000 IU B.jpg admin 21 Nov, 2019 69.33 Kb 722
13021 10,000 IU response.jpg admin 21 Nov, 2019 73.47 Kb 789
13020 10,000 IU safe sci-hub.pdf admin 21 Nov, 2019 912.75 Kb 609