Association between Serum 25-Hydroxy-Vitamin D and Aggressive Prostate Cancer in African American Men
Nutrients 2017, 9(1), 12; doi:10.3390/nu9010012 (registering DOI)
Shakira M. Nelson 1,2,* , Ken Batai 3, Chiledum Ahaghotu 4, Tanya Agurs-Collins 5 and Rick A. Kittles 3
- 1 Cancer Prevention Fellow, Division of Cancer Prevention, National Cancer Institute, 9609 Medical Center Drive, Room 6E402, Bethesda, MD 20892, USA
- 2 Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Room 6E402, Bethesda, MD 20892, USA
- 3 Division of Urology, Department of Surgery, The University of Arizona, Tucson, AZ 85721, USA
- 4 Chief Medical Officer, Carney Hospital-Steward Health Systems, Dorchester, MA 02124, USA
- 5 Health Behavior Research Branch, Division of Cancer Control and Population Studies, National Cancer Institute, 9609 Medical Center Drive, Bethesda, MD 20892, USA
- Blacks with prostate cancer were 7 X more likely to have aggressive prostate cancer if they also supplemented with more than 800 mg of Calcium Daily
- Blacks somewhat more likely to have aggressive prostate cancer if all 3 VDR genes were poor
- Blacks with aggressive prostate Cancer were also more likely to have quit smoking
See also VitaminDWiki
- Overview Prostate Cancer and Vitamin D
- Smoking reduces vitamin D - many studies
probably the reduction of vitamin D levels while still smoking increased the growth of prostate cancer - Death by Calcium, book by Thomas Levy – Dec 2013
- Increased Vitamin K2 reduces the problems of excess Calcium – Nov 2013
Vitamin K2 reduces Calcium getting into wrong locations - like blood vessels and probably Prostate - Is a health problem associated with Low vitamin D, Low Magnesium, or too much Calcium – Jan 2016
More Magnesium might reduce Prostate Cancer as well - Vitamin D Cofactors in a nutshell
Pages listed in BOTH the categories Prostate Cancer and Dark Skin
- Prostate cancer patients in Jamaica were 5X more likely to die of PC if low vitamin D - Sept 2022
- Prostate Cancer risk in black men increased 2X having poor Vitamin D Binding Protein – July 2017
- Prostate cancer in black men is 1.6 times more likely if a poor Vitamin D Receptor – Feb 2017
- Aggressive Prostate Cancer in blacks with low vitamin D – 7X more likely if added Calcium – Jan 2017
- Higher rate of prostate cancer in AA may decrease if take vitamin D – July 2016
- Prostate Cancer incidence and death 2X more often among black men (vitamin D not mentioned) - July 2015
- Tanning potential predicts risk of Prostate Cancer in Blacks – Nov 2014
- PSA levels in blacks were not changed by 3 months of 4,000 IU of vitamin D (not enough) – June 2014
- 2X less prostate cancer in A-A with low Calcium is due vitamin D receptor gene – July 2013
Pages listed in both of the categories Prostate Cancer and Calcium
_Pages listed in both of the categories Prostate Cancer and Vitamin D Receptor
- Book: Sunlight, UV, Vitamin D and Receptor, Skin and other Cancers - Dec 2020
- Prostate Cancer associated with various genes, including Vitamin D Receptor and CYP24A1 – Nov 2019
- Prostate surgery outcomes vary with Vitamin D Receptors– May 2017
- Prostate cancer in black men is 1.6 times more likely if a poor Vitamin D Receptor – Feb 2017
- Aggressive Prostate Cancer in blacks with low vitamin D – 7X more likely if added Calcium – Jan 2017
- High PSA readings with Prostate Cancer 4 times more likely if poor Vitamin D receptor – March 2016
- 2X less prostate cancer in A-A with low Calcium is due vitamin D receptor gene – July 2013
Vitamin D Receptor category has the following
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )
Several diseases protect themselves by deactivating the Vitamin D receptor. Example: Breast Cancer
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The Vitamin D Receptor is associated with many health problems
Some health problems, such as Breast Cancer, Diabetes, and COVID protect themselves by reducing VDR activation
55 health problems associated with poor VDR
A poor VDR is associated with the risk of 55 health problems click here for details
The risk of 48 diseases at least double with poor VDR as of Jan 2023 click here for details
Some health problem, such as Breast Cancer reduce the VDR
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
How to increase VDR activation
Compensate for poor VDR by increasing one or more:
| Increasing | Increases |
| 1) Vitamin D supplement Sun Ultraviolet -B | Vitamin D in the blood and thus in the cells |
| 2) Magnesium | Vitamin D in the blood AND in the cells |
| 3) Omega-3 | Vitamin D in the cells |
| 4) Resveratrol | Vitamin D Receptor |
| 5) Intense exercise | Vitamin D Receptor |
| 6) Get prescription for VDR activator paricalcitol, maxacalcitol? | Vitamin D Receptor |
| 7) Quercetin (flavonoid) | Vitamin D Receptor |
| 8) Zinc is in the VDR | Vitamin D Receptor |
| 9) Boron | Vitamin D Receptor ?, etc |
| 10) Essential oils e.g. ginger, curcumin | Vitamin D Receptor |
| 11) Progesterone | Vitamin D Receptor |
| 12) Infrequent high concentration Vitamin D Increases the concentration gradient | Vitamin D Receptor |
| 13) Sulfroaphane and perhaps sulfur | Vitamin D Receptor |
| 14) Butyrate especially gut | Vitamin D Receptor |
| 15) Berberine | Vitamin D Receptor |
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements that help the VDR
Download the PDF from VitaminDWiki
African American men have higher incidence rates of aggressive prostate cancer, where high levels of calcium and serum vitamin D deficient levels play a role in the racial differences in incidence. In this study, we examined associations of serum vitamin D with aggressive prostate cancer to improve our understanding of higher susceptibility of aggressive disease in this racial cohort. From Howard University Hospital, 155 African American men with clinically-identified prostate cancer were identified; 46 aggressive cases, and 58 non-aggressive cases. Serum vitamin D was assessed from fasting blood samples, and total calcium intake was assessed using the Block Food Frequency Questionnaire.
Vitamin D receptor polymorphisms from three different loci were genotyped;
- rs731236,
- rs1544410, and
- rs11568820.
Multivariate logistic regression models were used to determine odds ratios (OR) and 95% confidence intervals (CI) comparing aggressive to non-aggressive prostate cancer. Vitamin D deficiency (<20 ng/mL) significantly increased risk of aggressive disease (OR: 3.1, 95% CI: 1.03–9.57, p-value = 0.04). Stratification by total calcium showed high calcium levels (=800 mg/day) modified this association (OR: 7.3, 95% CI: 2.15–47.68, p-interaction = 0.03). Genetic variant rs11568820 appeared to increase the magnitude of association between deficient serum vitamin D and aggressive prostate cancer (OR: 3.64, 95% CI: 1.12–11.75, p-value = 0.05). These findings suggest that high incidence of aggressive prostate cancer risk in African
American men may be due in-part to deficient levels of serum vitamin D. Other factors, including genetics, should be considered for future studies.
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