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Long-COVID fatigue reduced by Vitamin C and l-Arginine in one month– RCT Nov 2022

Effects of l-Arginine Plus Vitamin C Supplementation on Physical Performance, Endothelial Function, and Persistent Fatigue in Adults with Long COVID: A Single-Blind Randomized Controlled Trial

Nutrients 2022, 14(23), 4984; https://doi.org/10.3390/nu14234984
Matteo Tosato 1, Riccardo Calvani 1,*, Anna Picca 1,2, Francesca Ciciarello 1, Vincenzo Galluzzo 1, Hélio José Coelho-Júnior 1,3, Angela Di Giorgio 1, Clara Di Mario 4, Jacopo Gervasoni 1, Elisa Gremese 1,3,4, Paolo Maria Leone 1, Antonio Nesci 1, Anna Maria Paglionico 1, Angelo Santoliquido 1,5, Luca Santoro 1, Lavinia Santucci 6, Barbara Tolusso 4, Andrea Urbani 1,7, Federico Marini 8, Emanuele Marzetti 1,3 and Francesco Landi 1,3 on behalf of the Gemelli against COVID-19 Post-Acute Care Team

Distance traveled during 6 minute walk test


Long COVID, a condition characterized by symptom and/or sign persistence following an acute COVID-19 episode, is associated with reduced physical performance and endothelial dysfunction. Supplementation of l-arginine may improve endothelial and muscle function by stimulating nitric oxide synthesis. A single-blind randomized, placebo-controlled trial was conducted in adults aged between 20 and 60 years with persistent fatigue attending a post-acute COVID-19 outpatient clinic. Participants were randomized 1:1 to receive twice-daily orally either a combination of 1.66 g l-arginine plus 500 mg liposomal vitamin C or a placebo for 28 days. The primary outcome was the distance walked on the 6 min walk test. Secondary outcomes were handgrip strength, flow-mediated dilation, and fatigue persistence. Fifty participants were randomized to receive either l-arginine plus vitamin C or a placebo. Forty-six participants (median (interquartile range) age 51 (14), 30 [65%] women), 23 per group, received the intervention to which they were allocated and completed the study.
At 28 days, l-arginine plus vitamin C increased the 6 min walk distance (+30 (40.5) m; placebo: +0 (75) m, p = 0.001) and induced a greater improvement in handgrip strength (+3.4 (7.5) kg) compared with the placebo (+1 (6.6) kg, p = 0.03). The flow-mediated dilation was greater in the active group than in the placebo (14.3% (7.3) vs. 9.4% (5.8), p = 0.03).
At 28 days, fatigue was reported by two participants in the active group (8.7%) and 21 in the placebo group (80.1%; p <0.0001).
l-arginine plus vitamin C supplementation improved
(walking performance,

  • muscle strength,
  • endothelial function, and
  • fatigue

in adults with long COVID. This supplement may, therefore, be considered to restore physical performance and relieve persistent symptoms in this patient population.
 Download the PDF from VitaminDWiki

See also Long-COVID is now the biggest COVID concern - many studies

60+ VitaminDWiki pages have LONG-HAUL or LONG-COVID in the title

L-arginine allow production of Nitric Oxide (also produced in the skin by sunlight) Life Extension

  • "In healthy adults, L-arginine is a nonessential amino acid, which means that your body is able to produce some of it on its own"

Created by admin. Last Modification: Thursday November 24, 2022 13:11:25 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
18851 Long walk test.jpg admin 24 Nov, 2022 11.30 Kb 362
18850 Long-COVID fatigue Vitamin C_CompressPdf.pdf admin 24 Nov, 2022 327.44 Kb 134