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Pancreatitis and Vitamin D - many studies

Vitamin D: A Potential Star for Treating Chronic Pancreatitis - June 2022

Front. Pharmacol., 06 June 2022 | https://doi.org/10.3389/fphar.2022.902639
Meifang Zheng and Runping Gao*
Department of Hepatic Biliary Pancreatic Medicine, The First Hospital of Jilin University, Changchun, China




Chronic pancreatitis (CP) is a chronic inflammatory and fibrotic disease of the pancreas. The incidence of CP is increasing worldwide but the effective therapies are lacking. Hence, it is necessary to identify economical and effective agents for the treatment of CP patients. Vitamin D (VD) and its analogues have been confirmed as pleiotropic regulators of cell proliferation, apoptosis, differentiation and autophagy. Clinical studies show that VD deficiency is prevalent in CP patients. However, the correlation between VD level and the risk of CP remains controversial. VD and its analogues have been demonstrated to inhibit pancreatic fibrosis by suppressing the activation of pancreatic stellate cells and the production of extracellular matrix. Limited clinical trials have shown that the supplement of VD can improve VD deficiency in patients with CP, suggesting a potential therapeutic value of VD in CP. However, the mechanisms by which VD and its analogues inhibit pancreatic fibrosis have not been fully elucidated. We are reviewing the current literature concerning the risk factors for developing CP, prevalence of VD deficiency in CP, mechanisms of VD action in PSC-mediated fibrogenesis during the development of CP and potential therapeutic applications of VD and its analogues in the treatment of CP.
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Vitamin D and Pancreatitis: A Narrative Review of Current Evidence - May 2022

Nutrients 2022, 14(10), 2113; https://doi.org/10.3390/nu14102113
by Fei Cai 1,†ORCID,Cheng Hu 1,†ORCID,Chan-Juan Chen 1,Yuan-Ping Han 2,Zi-Qi Lin 1,Li-Hui Deng 1,* andQing Xia 1
1 Department and Laboratory of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu 610041, China
2 The Center for Growth, Metabolism and Aging, College of Life Sciences, Sichuan University, Chengdu 610017, China

Emerging research indicates that vitamin D metabolic disorder plays a major role in both acute pancreatitis (AP) and chronic pancreatitis (CP). This has been demonstrated by studies showing that vitamin D deficiency is associated with pancreatitis and its anti-inflammatory and anti-fibrotic effects by binding with the vitamin D receptor (VDR). However, the role of vitamin D assessment and its management in pancreatitis remains poorly understood. In this narrative review, we discuss the recent advances in our understanding of the molecular mechanisms involved in vitamin D/VDR signaling in pancreatic cells; the evidence from observational studies and clinical trials that demonstrate the connection among vitamin D, pancreatitis and pancreatitis-related complications; and the route of administration of vitamin D supplementation in clinical practice. Although further research is still required to establish the protective role of vitamin D and its application in disease, evaluation of vitamin D levels and its supplementation should be important strategies for pancreatitis management according to currently available evidence.
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Osteoporosis is 1.9X more likely if have Acute Pancreatitis - 2020

The Risk of Vitamin D Deficiency, Osteoporosis, and Fractures in Acute Pancreatitis
Pancreas: 5/6 2020 - p 629-633 doi: 10.1097/MPA.0000000000001538 PDF behind paywall
Abou Saleh, Mohannad MD∗; Alkhayyat, Motasem MD†; Mansoor, Emad MD‡; Khoudari, George MD†; Simons-Linares, C. Roberto MD∗; Vargo, John MD∗; Chahal, Prabhleen MD∗; Stevens, Tyler MD∗

A few past studies have found increased utilization of 25-hydroxyvitamin D and prevalence of osteoporosis in acute pancreatitis (AP). Our aim was to obtain a survey of bone diseases after a sentinel episode of AP.

A database (Explorys), an aggregate of electronic health record from 26 integrated United States healthcare systems, was queried. A cohort of patients with a Systematized Nomenclature of Medicine—Clinical Terms diagnosis of AP between 2014 and 2019, after excluding patients with selected medical conditions and medications that are associated with poor bone health, was identified. The prevalence of new diagnoses of vitamin D deficiency (VDD), osteoporosis, and fractures in the study cohort was evaluated. Age-, race-, and sex-based distributions and risk factors were determined through univariate and multivariate analyses.

Of the 36,087,380 individuals in the database, we identified 256,580 (0.71%) with AP. In multivariate analysis, patients with AP were more likely to develop VDD (odds ratio OR, 1.25; 95% confidence interval CI, 1.24–1.26; P < 0.0001), osteoporosis (OR, 1.89; CI, 1.81–1.85; P < 0.0001), and fractures (OR, 1.58; 95% CI, 1.57–1.59; P < 0.0001).

Acute pancreatitis was associated with increased risk of VDD, osteoporosis, and fractures.

Systematic review and meta-analysis on the prevalence of vitamin D deficiency in patients with chronic pancreatitis - 2016

Pancreatology, Available online 18 July 2016, doi:10.1016/j.pan.2016.07.010
S.A. Hoogenbooma, 1, S.J. Lekkerkerkera, 1, P. Fockensa, M.A. Boermeesterb, J.E. van Hoofta, ,

Patients with chronic pancreatitis (CP) are at risk of malnutrition due to malabsorption, pain and/or alcohol consumption. This can cause vitamin D insufficiency or deficiency, which is associated with osteoporosis and increased risks of fractures. We aimed to perform a meta-analysis to determine the prevalence of vitamin D insufficiency and deficiency in CP patients. Furthermore, we compared these results with healthy controls.

We performed a systematic review and meta-analysis on the literature by searching PubMed and EMBASE (January 2000–December 2015) on CP and vitamin D. Primary outcome was prevalence of vitamin D insufficiency (<75 nmoL/L) and deficiency (<50 nmoL/L) in CP patients. When available, data of CP patients were compared with healthy controls.

Nine studies were included in our meta-analysis, reporting on the prevalence of vitamin D insufficiency/deficiency in 465 patients (mean age 41 years (range 18–60), 81% male) and in 378 controls (mean age 40 years (range 18–67), 76% male). Pooled prevalence of vitamin D insufficiency and deficiency in CP patients was 83% and 65%, respectively. Calculated odds ratio (OR) of vitamin D insufficiency and deficiency between CP patients and controls was 1.34 (0.54–3.29) and 1.14 (0.70–1.85), respectively (p > 0.05).

There is a high prevalence of vitamin D insufficiency and deficiency in CP patients. Nevertheless, there is no significant difference in prevalence of vitamin D insufficiency and deficiency compared to healthy controls. Further research should indicate the clinical relevance and consequences of these findings for clinical practice.

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Pancreatitis associated with poor Vitamin D Binding Protein and Receptor (in dogs) July 2023

DOI: 10.1111/jvim.16809 FREE PDF

VitaminDWiki Inflammation pages with PANCREATITIS in title (6 as of June 2022)

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VitaminDWiki - Inflammation category contains

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ID Name Comment Uploaded Size Downloads
17855 CP Table 4.jpg admin 13 Jun, 2022 10:31 90.19 Kb 300
17854 CP Table 3.jpg admin 13 Jun, 2022 10:31 155.78 Kb 300
17853 CP table 1.jpg admin 13 Jun, 2022 10:27 134.24 Kb 323
17852 Pancreatitis narrative.pdf PDF 2022 admin 13 Jun, 2022 10:17 888.22 Kb 181
17851 Vitamin_D_A_Potential_Star_for_Treating_Chronic_Pa_CompressPdf.pdf PDF 2022 admin 13 Jun, 2022 10:07 799.24 Kb 162