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COVID-19 deaths strongly correlated with percent having less than 10 ng of Vitamin D in a country– July 1 2020

Strong Correlation Between Prevalence of Severe Vitamin D Deficiency and Population Mortality Rate from COVID-19 in Europe

Preprint doi: https://doi.org/10.1101/2020.06.24.20138644
Isaac Z. Pugach, M.D. (Complete Med Care, Dallas, Texas), and
Sofya Pugach, M.D., Ph.D., MPH (Complete Med Care, Dallas, Texas) drpugach at yahoo.com

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Background: SARS-CoV-2 virus causes a very wide range of COVID-19 disease severity in humans: from completely asymptomatic to fatal, and the reasons behind it are often not understood. There is some data that Vitamin D may have protective effect, so authors decided to analyze European country-wide data to determine if Vitamin D levels are associated with COVID-19 population death rate.

Methods: To retrieve the Vitamin D levels data, authors analyzed the Vitamin D European population data compiled by 2019 ECTS Statement on Vitamin D Status published in the European Journal of Endocrinology. For the data set to used for analysis, only recently published data, that included general adult population of both genders ages 40-65 or wider, and must have included the prevalence of Vitamin D deficiency.

Results: There were 10 countries data sets that fit the criteria and were analyzed. Severe Vitamin D deficiency was defined as 25(OH)D less than 25 nmol/L (10 ng/dL). Pearson correlation analysis between death rate per million from COVID-19 and prevalence of severe Vitamin D deficiency shows a strong correlation with r = 0.76, p = 0.01, indicating significant correlation. Correlation remained significant, even after adjusting for age structure of the population. Additionally, over time, correlation strengthened, and r coefficient asymptoticaly increased.

Conclusions: Authors recommend universal screening for Vitamin D deficiency, and further investigation of Vitamin D supplementation in randomized control studies, which may lead to possible treatment or prevention of COVID-19.


Created by admin. Last Modification: Wednesday July 22, 2020 20:24:16 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
13976 10 ng data.jpg admin 01 Jul, 2020 40.71 Kb 563
13974 Mortality less than 10 ng.jpg admin 01 Jul, 2020 50.04 Kb 39466
13973 Strong Correlation Vitamin D Deficiency and COVID-19 Mortality - July 1.pdf admin 01 Jul, 2020 161.08 Kb 462