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Vitamin D prevents smoke lung damage in mice (If you must smoke, take vitamin D) – Nov 2019

Effect of Vitamin D3 on Lung Damage Induced by Cigarette Smoke in Mice

Open Med (Wars). 2019; 14: 827–832, . doi: 10.1515/med-2019-0096
Xin Zheng,*,1 Nini Qu,1 Lina Wang,1 Guoli Wang,1 Rui Jiao,1 Hu Deng,1 Sijia Li,2 and Yibing Qin2


1 hour of smoke per day, 6 days a week, for 16 weeks
21 gram mice, 1,000 IU Vitamin D (daily?) (study also tried 2,000 and 3,000 IU)
A human weighs about 3,800 X more than a 21 gram mouse
Vitamin D equiv. for human would thus be 3.8 million IU – which seems very unlikely

Comments by founder of VitaminDWiki

Seems like far too much vitamin D was used by this study.
A daily loading dose of 50,000 IU each day for the first week is popular (to quickly restore vitamin D levels)
4,000 IU daily on-going for humans is popular (or 50,000 IU every 2 weeks)
IF the dose size is proportional to weight between mice and humans, then mouse doses should be~ 4000 X smaller

See also VitaminDWiki

Smoking reduces vitamin D - many studies contains the following

Two pathways are often proposed for how smoking decreases vitamin D:
   1) Smoking decreases Calcium. and Vitamin D is used up in replacing the Calcium
   2) Smoking injures the body, and vitamin D is used up in repairing the body
It appears that taking Vitamin D while smoking will:
   1) Decrease the incidence of the many health problems associated with smoking - even lung cancer
   2) Decrease the desire to smoke (perhaps take fewer smoking breaks?)
   3) Increase breathing capacity
Opinion: If you must smoke, have recently smoked, or are getting 2nd hand smoke:
   take Vitamin D and perhaps Omega-3
    They will extinguish much of the inflammation caused by inhaling tobacco smoke.

Vitamin D should also help people quit smoking   See bottom of page Smoking reduces vitamin D - many studies
   1) Reduces weight gain associated with quitting smoking
   2) Reduces depression associated with quitting smoking

 Download the PDF from VitaminDWiki

Far less inflammation @ 16 weeks in mice getting Vitamin D

Almost as low inflammation as "non-smokers"

Lung microphotograph - normal


Lung microphotograph after 16 weeks of smoke


Lung microphotograph after 16 weeks of smoke and Vitamin D


Cigarette smoking is known to induce serious lung diseases, but there is not an effective method to solve this problem. The present study investigated vitamin D3 on over-expression of CXCR3 and CXCL10 in mice induced by cigarette smoking. A pulmonary airway model was designed, and morphological assessment of emphysema, IL-4, IFN-γ and CXCL10 concentration in bronchoalveolar lavage fluids, expression of CXCR3 and CXCL10 were detected. Emphysema of the mice only exposed to cigarette smoke was significant, and concentration of IL-4, IFN-γ and CXCL10 was also increased. In addition, CXCR3 and CXCL10 were over-expressed. The degree of emphysema, concentration of IL-4, IFN-γ and CXCL10, and expression of CXCR3 and CXCL10 in mice administrated with low dose vitamin D3 were similar to the normally treated mice. Low dose of vitamin D3 can effectively protect the lung from the damage induced by cigarette smoke.


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Created by admin. Last Modification: Saturday November 23, 2019 14:52:41 GMT-0000 by admin. (Version 11)

Attached files

ID Name Comment Uploaded Size Downloads
13035 Smoke + Vit D.jpg admin 23 Nov, 2019 27.47 Kb 605
13034 Smoke.jpg admin 23 Nov, 2019 18.01 Kb 587
13033 No smoke.jpg admin 23 Nov, 2019 30.84 Kb 667
13032 Smoke IP-10.jpg admin 23 Nov, 2019 18.92 Kb 683
13031 Effect of Vitamin D 3 on Lung Damage Induced by Cigarette Smoke.pdf admin 23 Nov, 2019 712.78 Kb 578