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Vitamin D and Respiratory Tract Infections – meta-analysis with charts June 2013

Vitamin D and Respiratory Tract Infections: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

PLoS ONE 8(6): e65835. doi:10.1371/journal.pone.0065835
Peter Bergman, Åsa U. Lindh, Linda Björkhem-Bergman, Jonatan D. Lindh

Background: Low levels of 25-OH vitamin D are associated with respiratory tract infection (RTI). However, results from randomized controlled trials are inconclusive. Therefore, we performed a systematic review and meta-analysis to assess the preventive effect of vitamin D supplementation on RTI.

Methods: Randomized, controlled trials of vitamin D for prevention of RTI were used for the analysis. The risks of within-trial and publication bias were assessed. Odds ratios of RTI were pooled using a random-effects model. Heterogeneity was assessed using Cochran's Q and I2. Meta-regressions and subgroup analyses were used to assess the influence of various factors on trial outcome. The pre-defined review protocol was registered at the PROSPERO international prospective register of systematic reviews, registration number CRD42013003530.

Findings: Of 1137 citations retrieved, 11 placebo-controlled studies of 5660 patients were included in the meta-analysis. Overall, vitamin D showed a protective effect against RTI (OR, 0.64; 95% CI, 0.49 to 0.84). There was significant heterogeneity among studies (Cohran's Q p<0.0001, I2 = 72%). The protective effect was larger in studies using once-daily dosing compared to bolus doses (OR = 0.51 vs OR = 0.86, p = 0.01). There was some evidence that results may have been influenced by publication bias.

Results: indicate that vitamin D has a protective effect against RTI, and dosing once-daily seems most effective. Due to heterogeneity of included studies and possible publication bias in the field, these results should be interpreted with caution.

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3921 Gargaling.pdf PDF 2014 admin 19 May, 2014 12:41 209.17 Kb 766
2612 RTI dose.jpg admin 21 Jun, 2013 15:41 23.73 Kb 1857
2611 RTI latitude.jpg admin 21 Jun, 2013 15:41 24.16 Kb 1794
2610 RTI subgroup.jpg admin 21 Jun, 2013 15:40 57.34 Kb 1770
2609 RTI summary.jpg admin 21 Jun, 2013 15:40 62.02 Kb 2051
2608 RTI meta-analysis.jpg admin 21 Jun, 2013 15:40 113.93 Kb 5553
2607 RTI meta-analysis.pdf PDF 2013 admin 21 Jun, 2013 15:39 628.08 Kb 918