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Muscle, etc. problems if consume little vitamin D (mice) – June 2018

Chronic vitamin D insufficiency impairs physical performance in C57BL/6J mice.

Aging (Albany NY). 2018 Jun 14. doi: 10.18632/aging.101471. [Epub ahead of print]
Seldeen KL1, Pang M1, Leiker MM1, Bard JE2, Rodríguez-Gonzalez M1, Hernandez M1, Sheridan Z1, Nowak N2, Troen BR1.


Started custom diet at age 6 months
Standard = 1,000 IU/day/kg of food
Low = 125 IU/day/kg of food

See also VitaminDWiki

Overview Sports and vitamin D has the following summary

Athletes are helped by vitamin D by:

  1. Faster reaction time
  2. Far fewer colds/flus during the winter
  3. Less sore/tired after a workout
  4. Fewer micro-cracks and broken bones
  5. Bones which do break heal much more quickly
  6. Increased VO2 and exercise endurance Feb 2011
  7. Indoor athletes especially need vitamin D
  8. Professional indoor athletes are starting to take vitamin D and/or use UV beds
  9. Olympic athletes have used UV/vitamin D since the 1930's
  10. The biggest gain from the use of vitamin D is by those who exercise less than 2 hours per day.
  11. Reduced muscle fatigue with 10,000 IU vitamin D daily
  12. Muscle strength improved when vitamin D added: 3 Meta-analysis
  13. Reduced Concussions
    See also: Sports and Vitamin D category 267 items

 Download the PDF from VitaminDWiki
Vitamin D levels vs month

How long grip remains strong

% of fat mass

Vitamin D insufficiency (serum 25-OH vitamin D < 30 ng/ml) affects 70-80% of the general population, yet the long-term impacts on physical performance and the progression of sarcopenia are poorly understood. We therefore followed 6-month-old male C57BL/6J mice (n=6) consuming either sufficient (STD, 1000 IU) or insufficient (LOW, 125 IU) vitamin D3/kg chow for 12 months (equivalent to 20-30 human years). LOW supplemented mice exhibited a rapid decline of serum 25-OH vitamin D levels by two weeks that remained between 11-15 ng/mL for all time points thereafter.
After 12 months LOW mice displayed worse

  • grip endurance (34.6 ± 14.1 versus 147.5 ± 50.6 seconds, p=0.001),
  • uphill sprint speed (16.0 ± 1.0 versus 21.8 ± 2.4 meters/min, p=0.0007), and
  • stride length (4.4 ± 0.3 versus 5.1 ± 0.3, p=0.002).

LOW mice also showed

  • less lean body mass after 8 months (57.5% ± 5.1% versus 64.5% ± 4.0%, p=0.023),
  • but not after 12 months of supplementation,
  • as well as greater protein expression of atrophy pathway gene atrogin-1.

Additionally, microRNA sequencing revealed differential expression of mIR-26a in muscle tissue of LOW mice.
These data suggest chronic vitamin D insufficiency may be an important factor contributing to functional decline and sarcopenia.

PMID: 29905532 DOI: 10.18632/aging.101471

Serum 25-OH vitamin D declines rapidly and remains consistently depressed in response to low supplementation. Prolonged vitamin D insufficiency induces characteristics of sarcopenia that include poor anaerobic capacity, lower lean mass, and a trend towards smaller fast twitch fiber CSA, as well as gait disturbance. Vitamin D insufficient mice also exhibited increased expression of atrophy-associated Atrogin-1 and differential expression of muscle regulation associated miR-26a. These data suggest a role for chronic vitamin D insufficiency in the development of sarcopenia, highlighting the need for further animal and human studies to investigate the impacts of vitamin D during aging.

Created by admin. Last Modification: Saturday June 30, 2018 00:21:37 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
10037 Fat mass.jpg admin 27 Jun, 2018 20:52 13.76 Kb 540
10036 Vit D vs age.jpg admin 27 Jun, 2018 20:51 24.93 Kb 550
10035 Grip latency.jpg admin 27 Jun, 2018 20:51 14.19 Kb 608
10034 Aging Vitamin D Mice.pdf PDF 2018 admin 27 Jun, 2018 20:51 1.90 Mb 546