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Large dose of calcifediol or vitamin D up to 15 days before COVID hospitalization reduced death rates (1.5X, 1.3X) – Dec 2021

Real world evidence of calcifediol or vitamin D prescription and mortality rate of COVID-19 in a retrospective cohort of hospitalized Andalusian patients

Sci Rep. 2021 Dec 3;11(1):23380. doi: 10.1038/s41598-021-02701-5
Carlos Loucera 1 2, María Peña-Chilet 1 2 3, Marina Esteban-Medina 1 2, Dolores Muñoyerro-Muñiz 4, Román Villegas 4, Jose Lopez-Miranda 5 6, Jesus Rodriguez-Baño 2 7 8, Isaac Túnez 9 10 11 12, Roger Bouillon 13, Joaquin Dopazo 14 15 16 17, Jose Manuel Quesada Gomez 18 19

COVID-19 is a major worldwide health problem because of acute respiratory distress syndrome, and mortality. Several lines of evidence have suggested a relationship between the vitamin D endocrine system and severity of COVID-19. We present a survival study on a retrospective cohort of 15,968 patients, comprising all COVID-19 patients hospitalized in Andalusia between January and November 2020. Based on a central registry of electronic health records (the Andalusian Population Health Database, BPS), prescription of vitamin D or its metabolites within 15-30 days before hospitalization were recorded. The effect of prescription of vitamin D (metabolites) for other indication previous to the hospitalization was studied with respect to patient survival. Kaplan-Meier survival curves and hazard ratios support an association between prescription of these metabolites and patient survival. Such association was stronger for

  • calcifediol (Hazard Ratio, HR = 0.67, with 95% confidence interval, CI, of [0.50-0.91]) than for
  • cholecalciferol (HR = 0.75, with 95% CI of [0.61-0.91]),

when prescribed 15 days prior hospitalization.
Although the relation is maintained, there is a general decrease of this effect when a longer period of 30 days prior hospitalization is considered (calcifediol HR = 0.73, with 95% CI [0.57-0.95] and cholecalciferol HR = 0.88, with 95% CI [0.75, 1.03]), suggesting that association was stronger when the prescription was closer to the hospitalization.
 Download the PDF from VitaminDWiki

Observation by VitaminDWiki

Apparently this region in Spain prescribed either 256 mcg of calcifediol or 25,000 IU of vitamin D
These appear to be once a month doses
It appears that only those with <20 of vitainm D are given these prescroptions
Many other studies have found both to fight COVID - via prevention or tratment
Suspect that these are not new prescrptions, but rather just the day a new pill was given (have sent a question to one of the authors)

VitaminDWiki studies in both of the categories Calcidiol (calcifediol) and Virus

Amazon (US) now sells calcifediol


~2 months supply of calcifediol costs $20
Vs 2 months supply of Vitamin D (50,000 IU) costs ~ 20 cents (100 X lower cost)

VitaminDWiki - Vitamin D meta-analyses for Virus

VITAMINDWiki - COVID-19 treated by Vitamin D - studies, reports, videos

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Created by admin. Last Modification: Saturday December 4, 2021 20:45:48 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
16694 Amazon.jpg admin 04 Dec, 2021 20:42 24.86 Kb 240
16693 Calcidiol Amazon.jpg admin 04 Dec, 2021 20:42 96.22 Kb 254
16692 Chol Cal 15 day HR.jpg admin 04 Dec, 2021 19:58 19.20 Kb 224
16691 calcifediol COVID observation.pdf PDF 2021 admin 04 Dec, 2021 19:49 1.41 Mb 454