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Fibromyalgia and Musculoskeletal Pain treated by raised Vitamin D levels – July 2022

The Efficacy of Vitamin D Supplementation in the Treatment of Fibromyalgia Syndrome and Chronic Musculoskeletal Pain

Nutrients 2022, 14(15), 3010; https://doi.org/10.3390/nu14153010
by Mauro Lombardo 1,*ORCID,Alessandra Feraco 1,2,Morena Ottaviani 1,Gianluca Rizzo 3ORCID,Elisabetta Camajani 1,4ORCID,Massimiliano Caprio 1,2ORCID andAndrea Armani 1,2
1 Dept. of Human Sciences and Promotion of the Quality of Life, San Raffaele Open University, 00166 Rome, Italy
2 Lab. of Cardiovascular Endocrinology, San Raffaele Research Institute, IRCCS San Raffaele Roma, Via di Val Cannuta, 247, 00166 Rome, Italy
3 Independent Researcher, Via Venezuela 66, 98121 Messina, Italy
4 PhD Program in Endocrinological Sciences, Dept of Experimental Medicine, U. of Rome “La Sapienza”, Piazzale Aldo Moro, 5, 00185 Rome, Italy

Fibromyalgia syndrome (FMS) and chronic widespread musculoskeletal pain (CMP) are diffuse suffering syndromes that interfere with normal activities. Controversy exists over the role of vitamin D in the treatment of these diseases. We carried out a systematic literature review of randomized controlled trials (RCT) to establish whether vitamin D (25OHD) deficiency is more prevalent in CMP patients and to assess the effects of vitamin D supplementation in pain management in these individuals. We searched PubMed, Physiotherapy Evidence Database (PEDro), and the Cochrane Central Register of Controlled Trials (CENTRAL) for RCTs published in English from 1 January 1990 to 10 July 2022. A total of 434 studies were accessed, of which 14 satisfied the eligibility criteria. In our review three studies, of which two had the best-quality evidence, a correlation between diffuse muscle pain and 25OHD deficiency was confirmed. Six studies, of which four had the best-quality evidence, demonstrated that appropriate supplementation may have beneficial effects in patients with established blood 25OHD deficiency. Eight studies, of which six had the best-quality evidence, demonstrated that 25OHD supplementation results in pain reduction. Our results suggest a possible role of vitamin D supplementation in alleviating the pain associated with FMS and CMP, especially in vitamin D-deficient individuals.

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157 items in category Chronic pain

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Created by admin. Last Modification: Saturday July 23, 2022 15:08:24 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
18169 Fibromyalgia Syndrome and CMP.pdf admin 23 Jul, 2022 14:18 435.12 Kb 93
18168 FMS CMP table.jpg admin 23 Jul, 2022 14:17 41.59 Kb 132