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COVID probably fought by Vitamin D, might need 50 ng - Dr. Patrick Nov 8, 2021


Vitamin D may protect against COVID-19 - email by Dr. Rhonda Patrick, Nov 8, 2021

Throughout the pandemic, evidence that having adequate vitamin D levels might lower a person's risk of COVID-19 has continued to mount. For example, one study involving nearly 8,300 adults enrolled in the UK Biobank study found that those who took vitamin D regularly (daily or weekly) were 34 percent less likely to develop COVID-19 compared to those who did not take vitamin D. This effect was exclusive to supplementation with vitamin D, not other supplements, suggesting a link to vitamin D specifically. Other studies have shown that... 

What's driving the protective connection between vitamin D and COVID-19?

Many things. But one, in particular, stands out: regulation of the renin-angiotensin system. A key player in this system is ACE2, a protein found on the surface of many cells in the body. You might already know that ACE2 serves as the SARS-CoV-2 entry point into our cells. But ACE2 is critical for the conversion of angiotensin II to angiotensin 1-7, a process that helps regulate blood pressure and fluid balance in the body and is linked to immune health and protection from COVID-19, as we show in this figure:Image
 
SARS-CoV-2 binds to ACE2 and takes the ACE2 protein with it, impairing ACE2 function and perturbing the balance between angiotensin II and angiotensin 1-7. Ultimately, this imbalance can trigger acute respiratory distress syndrome (ARDS), the primary cause of death from COVID-19. Vitamin D blocks this by increasing ACE2. Learn more.

Here's how it works. 
Angiotensin II is a vasoconstrictor, but it also promotes inflammation and oxidative stress. In a good enzyme/bad enzyme scenario, angiotensin 1-7 keeps angiotensin II in check, but only when a balance between the two enzymes is maintained. 
Unfortunately, when SARS-CoV-2 binds to the ACE2 protein to gain entry into cells, it takes the ACE2 protein into the cell with it, impairing ACE2 function and perturbing the balance between angiotensin II and angiotensin 1-7. Ultimately, this promotes inflammation and can trigger acute respiratory distress syndrome (ARDS), the primary cause of death from COVID-19. 
Vitamin D may prevent ARDS 
Vitamin D blocks the production of renin and angiotensin II and stimulates expression of ACE2. The end result: greater conversion of angiotensin II to angiotensin 1-7 and protection from ARDS. 
How much vitamin D do we need for protection against COVID-19? 
The vitamin D "sweet spot" may be 50 ng/ml 
A recent study analyzed data from a population-based study measuring long-term vitamin D status in more than 400 million people worldwide, as well as seven clinical studies measuring vitamin D levels post-infection. The result? People who had vitamin D levels of 50 nanograms per milliliter (ng/ml) or higher preceding SARS-CoV-2 infection were extremely unlikely to die from their illness, suggesting that vitamin D may reduce the risk of death from COVID-19 – theoretically to a level of ZERO. 
The 50 ng/ml figure aligns with the classifications established by the Endocrine Society

Based on these classifications, approximately 70 percent of people living in the United States have vitamin D insufficiency and 40 percent have deficiency – disturbing figures in light of vitamin D's importance in human health. 
Why not treat COVID-19 patients with vitamin D? 
A variety of interventional studies have popped up, asking this very question. Of course, one problem with this approach is that it's possible that by the time a person has COVID-19, supplementation may be "too little, too late," since vitamin D typically takes a long time to exhibit broad systemic effects. 
Nevertheless, one study put this to the test in 40 adults who had a positive SARS-CoV-2 RNA test, mild or no COVID-19 symptoms, and vitamin D deficiency. The investigators assigned 16 study participants to take 60,000 international units of vitamin D3 orally until they reached a blood level greater than 50 ng/ml. 
After two weeks of supplementation, 75 percent of the participants achieved a vitamin D blood level greater than 50 ng/ml. Those who corrected their deficiency were more likely to clear the virus by day 21 of the study. They also experienced a decrease in serum fibrinogen, a marker of inflammation. 
Bottom line? Public health measures such as getting vaccinated, wearing masks indoors in high-risk areas, maintaining social distance, and washing hands are crucial for reducing your risk of getting COVID-19. Robust evidence suggests that maintaining healthy vitamin D status can play a role, too.

Want to learn more about vitamin D, ACE2, and COVID-19?

Check out these FMF resources:

Free genetics reports analyzing SNPs involved in vitamin D metabolism and more:
 Upload your DNA data and take advantage of a free Micronutrient Report focused on SNPs related to the bioavailability and metabolism of micronutrients including vitamin D.
Or try the free Viral Report, which includes a detailed analysis on SNPs that have been studied in the context of SARS-CoV-2, SARS-CoV-1, ACE2 gene expression, acute respiratory distress syndrome (ARDS), flu risk, and more.


VitaminDWiki

COVID-19 treated by Vitamin D - studies, reports, videos

As of Jan 31, 2024, the VitaminDWiki COVID page had:  19+ trial results,   37+ meta-analyses and reviews,   Mortality studies   see related:   Governments,   HealthProblems,   Hospitals,  Dark Skins,   All 26 COVID risk factors are associated with low Vit D,   Fight COVID-19 with 50K Vit D weekly   Vaccines   Take lots of Vitamin D at first signs of COVID   166 COVID Clinical Trials using Vitamin D (Aug 2023)   Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
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VitaminDWiki pages with PATRICK in title

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Items found: 19
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The Science of Magnesium and Its Role in Aging and Disease - Patrick March 2024 20 Mar, 2024
Reduce ageing with Vitamin D, Omega-3, and Exercise (video) - Patrick March 2024 06 Mar, 2024
High Omega-3 index increases longevity, even among smokers - Patrick Jan 2024 17 Jan, 2024
The Longevity and Brain Benefits of Vigorous Exercise - Patrick video Dec 2023 05 Dec, 2023
Benefits of Omega-3s - video and transcript - Patrick - Nov 2023 29 Nov, 2023
The Dangers of Vitamin D Deficiency (and why you should supplement), Video and transcript, Patrick - Nov 2023 29 Nov, 2023
Longevity experts take Vitamin D, Omega-3, and Magnesium - Patrick video Sept 2023 10 Nov, 2023
How Vitamin D, Omega-3s, and Exercise May Increase Longevity - Patrick Nov 2023 10 Nov, 2023
Vitamin D overview by Rhonda Patrick – Oct 2022 07 Oct, 2022
COVID probably fought by Vitamin D, might need 50 ng - Dr. Patrick Nov 8, 2021 21 Jul, 2022
Omega-3 decreases heart disease and COVID: Harris and Patrick, video and transcript - Dec 2021 07 Dec, 2021
Long-haul, VAERS, Ivermectin, vaccines, etc. Drs. Seheult, Patrick: Video with table of contents - Sept 17, 2021 21 Sep, 2021
COVID-19 fought by Vitamin D or Heat - Drs Seheult and Patrick video - March 3, 2021 07 Mar, 2021
Resveratrol benefits health in many ways - Dr. Patrick Sept 2019 26 Sep, 2019
Standard Omega-3 not get past BB barrier in seniors at high risk of Alzheimer’s – Patrick hypothesis Oct 2018 25 Dec, 2018
Benefits of Micronutrients, fasting, saunas, intense exercise, cold showers – Patrick April 2018 21 Apr, 2018
Off topic – Outline of 2 hour health webinar by Dr. Patrick – Oct 2017 12 Oct, 2017
Autism, Vitamin D, and serotonin - Patrick interview by Mercola Feb 2016 14 Feb, 2016
Micronutrients, methylation, epigenetics, longevity podcast by Rhonda Patrick and Tim Ferriss - June 2015 22 Jun, 2015

COVID-19 studies with 50 ng of Vitamin D


Created by admin. Last Modification: Wednesday January 31, 2024 03:26:01 GMT-0000 by admin. (Version 14)