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Overview Fibromyalgia or Chronic Fatigue and vitamin D

Did you know?
  • Large doses of vitamin D reduced CFS/Fibromyalgia in > 10 studies
  • Many books and online forums recommend vitamin D for CFS/Fibromyalgia
  • Vitamin D also reduces a wide variety of pains
          (More Fibromyalgia/CFS info below)

Learn how Vitamin D is essential for good health
  Watch a 5 minute video "Does Less Sun Mean more Disease?"
  Browse for other Health Problems and D in left column or here
  see also Supplementing and More in the menu at the top of every page
If you have a disease associated with low Vit D take Vit D
Raising your Vit D levels will substantially prevent other low-Vit D health problems
Proof that Vitamin D Works   Getting Vitamin D into your body

Is 50ng enough?   How to restore levels quickly  VitaminDWiki interview and transcript - Jan 2022
Books and Videos 241   Diseases that may be related via low vitamin D
Reasons for low response to vitamin D   Why are doctors reluctant
Cancer studies include:   Breast 248   Colon 139   Lung 54   Prostate 97   Pancreatic 55   Skin 119
Colds and flu   Dark Skin 458   Diabetes 529   Obesity 409   Pregnancy 860   Seniors 406
COVID-19 treated by Vitamin D - studies, reports, videos
  • Vitamin D Levels can be restored quickly within a week with a loading dose.
    • With a loading dose, you will probably feel the benefits in a week.
  • A Vitamin D test is generally NOT required before having a loading dose.
  • If you don't feel better within 2 weeks, you do not need to continue taking vitamin D for CFS/ME/Fibromyalgia.
       When stopped, your body will naturally reduce and eliminate any excess vitamin D within 2 months.

Source of above chart = Medscape
FibroGuide - easy introduction to Fibromyalgia featured on Medscape
Fibromyalgia is the second most common condition affecting your bones and muscles. WebMD 2017
huge resource, but nothing about Vitamin D

Chronic Fatigue Syndrome and Long-haul COVID-19

54+ VitaminDWiki pages with FIBROMYALGIA OR FATIGUE in the title

This list is automatically updated

Fibromyalgia treated with 50,000 IU Vitamin D weekly and rehab therapy for 6 months – June 2022

Can the Combination of Rehabilitation and Vitamin D Supplementation Improve Fibromyalgia Symptoms at All Ages?
J Funct Morphol Kinesiol. 2022 Jun 20;7(2):51. doi: 10.3390/jfmk7020051.
Dalila Scaturro 1, Fabio Vitagliani 2, Sofia Tomasello 3, Mirko Filippetti 4, Alessandro Picelli 4 5, Nicola Smania 4 5, Giulia Letizia Mauro 1
6 month Results (Group A <50, Group B >50)

  • Numerical Rating Scale (NRS),
  • Fibromyalgia Impact Questionnaire (FIQ),
  • Short Form 12 Health Survey (SF-12)

Several studies have indicated a correlation between vitamin D deficiency and widespread chronic pain syndromes, such as fibromyalgia. During this study, the effect of supplementation with vitamin D in association with physical exercise in patients with fibromyalgia was evaluated, in terms of improvement of pain, functional capacity, and quality of life, also evaluating the presence of any differences in age. A single-center, observational, comparative study was conducted on 80 fibromyalgia patients.
They are randomized into 2 groups:

  • Group A, consisting of patients ≤50 years; and
  • Group B consists of patients &>;50 years.

Both received weekly supplementation with 50,000 IU cholecalciferol for 3 months in association with a rehabilitation protocol. Patients were assessed at enrollment (T0), 3 months (T1), and 6 months (T2) from the initial assessment with blood vitamin D dosage and administration of rating scales (NRS, FIQ, and SF-12). From the comparison between the two groups, we have seen that in young people, supplementation with high-dose vitamin D improves short-term musculoskeletal pain and long-term functional capacity. Conversely, musculoskeletal pain and long-term quality of life improve in the elderly. Supplementing with high doses of vitamin D in fibromyalgia patients improves the quality of life and pain in the elderly and also the functional capacity in the young.
 Download the PDF from VitaminDWiki

11 of 12 studies found Vitamin D helped Fibromyalgia - review March 2022

Efficacy of Vitamin D Supplementation in the Improvement of Clinical Status in Patients Diagnosed with Fibromyalgia Syndrome: A Systematic Review
Curr Rheumatol Rev. 2022 Mar 7. doi: 10.2174/1573397118666220307122152 behind $95 paywall
Nanditha Venkatesan 1, Mallika Gyawali 2, Rinky A Botleroo 2, Rowan Ahmed 2, Roaa Kareem 2, Opemipo D Ogeyingbo 3, Renu Bhandari 4, Abeer O Elshaikh 2

Background Fibromyalgia syndrome is characterized by extensive muscular pain and chronic fatigue. Among the pharmacologic and other nutrient supplements that have been studied, Vitamin D has garnered attention owing to the critical role it plays in inflammatory and pain pathways. We conducted a systematic literature review to examine the efficacy of vitamin D supplementation in improving the clinical status of the patients and alleviating the symptoms of fibromyalgia.

Methods We searched Cochrane CENTRAL, PubMed, Science Direct, Scopus, and grey literature (medrXiv and biorXiv) for observational studies, randomized controlled trials, case-control studies, and case reports published in English from January 2011 to May 2021, using the terms vitamin D and fibromyalgia or FMS. References were reviewed manually, and articles were only included if they were specific in their diagnosis of fibromyalgia.
Results 2651 studies were retrieved, with 12 studies fulfilling the inclusion criteria. 11 out of these 12 studies were of high quality and showed a low risk of bias. 11 of these also demonstrated definitive improvement in clinical status and various outcome measures following supplementation with Vitamin D.

Conclusions Our study emphasizes an association between the supplementation of vitamin D and the improvement of the clinical condition of fibromyalgia through a systematic review of high-quality studies. The study also identified areas for future scope for research that is needed for standardizing the detection and treatment of this chronic condition through cost-effective supplements such as Vitamin D.

German website and book – relief in 1 week

Response with 400,000 IU loading dose @ is.gd/7DayVitD
Case studies in the book include Back and leg pain, Chronic fatigue, Lethargy, Fatigue, Exhaustion, Neck pain, and Emergency relief from exhaustion.

4 Vitamin D books with sections on Chronic Pain/ Fibromyalgia

  • The Vitamin D Solution: CFS on pages 4,12,67 Fibromyalgia 4, 6, 12, 65-68
  • The Vitamin D Cure: Chronic pain and Fibromyalgia pg 133-136
  • Power of Vitamin D: contained in chapters pg 25-34, available as an e-book for $5
  • Vitamin D Prescription: Fibromyalgia on pages 4, 20-23, 80-84, 171, 185, 198-199

Loading Dose of Vitamin D

Overview Loading of vitamin D
Check that you are not allergic to vitamin D by trying a small amount - say 1,000 IU and seeing any reactions (only about 1 in 300 people are)
The brand vitamin D with the least amount of additives and no reported bad reactions is Bio-Tech - which also is the highest-rated brand on Amazon.
Of the few people with reactions to vitamin D, many appear to be deficient in Magnesium - Magnesium Chloride is a good supplement.
A typical loading dose of 400,000 IU - can, for example, be achieved by 50,000 IU capsules once a day for 8 days.

After loading the dose, just one tiny capsule every 2 weeks

items Depression Category


items Headache category


items Hypothesis of Autoimmunity which includes Epstein-Barr Virus and Vitamin D Deficiency – 2012
Chronic Fatigue Syndrome was called Epstine Barr Virus before 1988 All items in category Chronic Pain


items Pain subjectively and objectively lower in people with higher levels of vitamin D – Aug 2014 100 Million Americans Have Chronic Pain – IoM June 2011

Fibromyalgia worse if low vitamin D – June 2020

Association Between Low Vitamin D Levels and the Greater Impact of Fibromyalgia
J Clin Med Res. 2020 Jul;12(7):436-442. doi: 10.14740/jocmr4136
Susyane Ribeiro Beserra 1, Fabiola Isabel Suano Souza 1, Roseli Oselka Saccardo Sarni 1, Myllena Maria de Morais Pereira 2
 Download the PDF from VitaminDWiki

Background: Fibromyalgia (FM) is a clinical syndrome mainly characterized by generalized chronic pain, fatigue, sleep, and cognition disorders. The role played by vitamin D in the pathophysiology of painful syndromes is poorly known. Studies assessing the association between vitamin D and FM have presented conflicting results. The aims of the current study were to assess vitamin D levels in FM patients by comparing them to healthy controls, as well as to analyze their impact on this disease.

Methods: This was a cross-sectional study comprising 43 FM patients (ACR 2010 criteria) and 40 healthy individuals. All participants had their vitamin D levels measured, and FM patients also had their total calcium, albumin, phosphorus, and parathyroid hormone (PTH) measured. Clinical variables capable of affecting the results were evaluated, and the fibromyalgia impact questionnaire (FIQ) was applied.

Results: There was no statistically significant difference in global mean values of vitamin D between groups. In the total sample, only 4.8% of the individuals had vitamin D deficiency, which corresponded to the deficiency found in the group of patients; in the control, no one had vitamin deficiency; 39.8% had insufficient levels, and 55.4% with sufficient levels. The mean serum vitamin D values were similar between the FM and control groups (34.8 ± 12 and 34.7 ± 12.3 ng/mL, respectively; P = 0.806). However, a significant negative correlation was found between vitamin D concentration and FIQ values; that is, patients with the greatest impact of the disease had lower concentrations of vitamin D (P = 0.018).

Conclusion: FM patients did not present a higher prevalence of vitamin D deficiency or insufficiency than healthy individuals, although low vitamin D concentrations could indicate more severe disease impacts.

Clipped from PDF
“…” fibromyalgia impact questionnaire (FIQ), which comprised questions organized into 10 different items focused on investigating participants’ functional capacity, professional status, psychological disorders, and physical symptoms.”

See also PubMed - CFS, Fibromyalgia, and Vitamin D.

Search for (fibromyalgia OR "Chronic Fatigue") "vitamin d" 105 items as of Dec 2020

See also web - CFS, Fibromyalgia




CDC on Fibromyalgia

  • Fibromyalgia is a disorder of unknown etiology characterized by widespread pain, abnormal pain processing, sleep disturbance, fatigue, and often psychological distress.
  • People with fibromyalgia may also have other symptoms, such as Morning stiffness, Tingling or numbness in hands and feet, Headaches, including migraines, Irritable bowel syndrome, Sleep disturbances, Cognitive problems with thinking and memory (sometimes called "fibro fog"), Painful menstrual periods and other pain syndromes.
  • Fibromyalgia often co-occurs (up to 25-65%) with other rheumatic conditions such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and ankylosing spondylitis (AS).
  • Prevalence 3.4% women, 0.5% men - averaged over all ages - increases with age
  • Working-age women with fibromyalgia hospitalized for occupational musculoskeletal disorders were almost 10 times less likely to return to work
    Causes and/or risk factors for fibromyalgia are unknown, but some things have been loosely associated with disease onset:
        Stressful or traumatic events, Repetitive injuries, Illness (e.g., viral infections), Certain diseases (i.e., SLE, RA, chronic fatigue syndrome), Genetic predisposition, Obesity
        Note by VitaminDWiki: most of these are associated with a decrease in vitamin D levels
  • Effect of Correction of Low Vitamin D in Fatigue Study (EViDiF Study) Aug 2014
    Full free text online. 50,000 IU of D2 3 times per week for 5 weeks got 96% of subjects > 30 ng. Total fatigue scores dropped from 33 down to 11
    same study described at Vitamin D Council free
  • A Primer on Chronic Fatigue Syndrome GreenMedInfo Jan 2015
    Mentions Vitamin D
  • Hope for Chronic Fatigue Syndrome SLATE Nov 2015
    "And the hallmark symptom of the illness is that exertion can make patients much, much worse."
    ". . . the National Institutes of Health spends $5 million to $6 million a year on a disease that affects a million Americans. (For comparison, about the same number of people with HIV/AIDS receives $3 billion in NIH funding.)"
    the article describes the major shortcomings of the previous PCE trial
  • ME isn’t just ‘exercise phobia’: it’s a physical illness. Nov 2015
    People die of Myalgic Encephalomyelitis (ME) when PCE-type techniques are used.
    74 percent of ME patients are harmed by the therapy
    • does not mention Vitamin D

Medscape set of articles on CFS/ Fibromyalgia 2014-2015

  1. Chronic Fatigue Syndrome: Wrong Name, Real Illness Jan 2015
    Called CFS in the US and elsewhere myalgic encephalomyelitis (ME). since 1988, defined by CDC in 1999
    '' malaise lasting days to weeks following even modest physical or mental exertion, unrefreshing sleep, and cognitive dysfunction.
    Chronic pain is common, and many patients also meet the criteria for fibromyalgia.
    ME/CFS appears to be more common among ethnic and racial minority groups and in those of lower socioeconomic status
    Many ME/CFS patients are able to pinpoint the condition's onset to a flulike illness from which they never recovered
  2. Fibromyalgia: The Latest in Diagnosis and Care Sept 2014
    It was previously called neurasthenia, then fibrositis (medical fas included removing organs to "cure" the problem)
    diagnostic criteria of 1990 and 2010 were meant to be used for research studies, not to diagnose individual patients.
    Now recommend looking at widespread pain accompanied by fatigue, sleep, memory, and mood problems
  3. Pain and Depression Treatment Possible in Fibromyalgia Sept 2014
  4. Chronic Fatigue Syndrome Aug 2014
  5. Fibromyalgia May 2014
    Lab testing includes a Metabolic panel, Urinalysis, Thyroid-stimulating hormone level, and 25-hydroxy vitamin D level.
    Vitamin B12. Iron, Magnesium, Erythrocyte sedimentation rate, Antipolymer antibody
    See also VitaminDWiki combined Vitamin D, Iron, Magnesium deficiencies
        Deficiencies of iron and vitamin D are interrelated in women
        Iron deficiency is a cause of Vitamin D deficiency which has an Iron supplement that is 23X better than typical.

Fibromyalgia description - diagnosis takes many years

Fibromyalgia - Burden of disease and disability and how it changed History by Drdoc on-line

Fibromyalgia pain is worse than labor pain

Pain Medical Musing from a 1988 book

If you have gut problems & Fibro - you may need a different form of Vitamin D

Standard Vitamin D is not absorbed well in poorly functioning guts (IBS, etc.)
There are many different "gut-friendly" forms of vitamin D
Vitamin D injection is far better than oral for diabetics (poor gut) – RCT March 2017

Nice body chart by Dr. Carey


EasyImmuneHealth 2014?

Fibromyalgia and Vitamin D Don't Get Misdiagnosed
Fibromyalgia and Vitamin D Deficiency very often have COMPLETELY IDENTICAL symptoms.
Large numbers of people have been misdiagnosed with Fibromyalgia when they simply have Vitamin D Deficiency- don't be one of them.

Chronic Fatigue Syndrome associated with different gut bacteria

5 Common Causes of Chronic Fatigue - Sept 2018

5 Common Causes of Chronic Fatigue and Tests That Help Reveal The Cause Self Hacked
1) Anemia: Iron Deficiency, Vitamin B12 Deficiency, Folate (Vitamin B9) Deficiency
   Overview Iron Supplements and Vitamin D
   Vitamin B12
2) Poor Thyroid Function (Hypothyroidism)
   Thyroid and vitamin D are the only body components which have a receptor on every cell in the body
  Hypothyroidism risk reduced 32 percent in those getting vitamin D levels above 50 ng – Oct 2017
  The Role of Vitamin D in Thyroid Diseases – Sept 2017
3) Vitamin D Deficiency
4) Poor Liver Function
5) Low Testosterone Levels

Magnesium fights Fibromyalgia - a few PubMed studies

  • Magnesium and Fibromyalgia: A Literature Review - 2021 PDF
  • Fibromyalgia and nutrition: Therapeutic possibilities? July 2018 (Magnesium) 10.1016/j.biopha.2018.04.056
    amino acids, magnesium, selenium, vitamins B and D
  • Effects of transdermal magnesium chloride on quality of life for patients with fibromyalgia: a feasibility study Sept 2016 doi: 10.1016/S2095-4964(15)60195-9

A Wiki dedicated to ME/ Chronic Fatigue Syndrome

https://me-pedia.org/wiki 3,000 entries as of April 2021
Has an OK entry for Vitamin D and CFS

CFS sufferer for 25 years helped by improving his mitochondria - May 2022

Toby Rodgers

  • He was helped by Sarah Myhill’s book, Diagnosis and Treatment of Chronic Fatigue Syndrome and Myalgic Encephalitis, 2nd ed.: It’s Mitochondria, Not Hypochondria
  • Johnson thinks ME/CFS is caused by a virus.8
  • "...estimated 1% of the global population has ME/CFS
  • took >20 years for him to be diagnosed as having ME/CFS
    • Note: on average, the time is 7 years to be diagnosed

Short URL = http://is.gd/fibrovitd

Overview Fibromyalgia or Chronic Fatigue and vitamin D        
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Attached files

ID Name Comment Uploaded Size Downloads
17959 Fibro 6 months.jpg admin 23 Jun, 2022 22:55 40.50 Kb 2494
17958 Fibro - Vitamin D and rehab.pdf PDF 2022 admin 23 Jun, 2022 22:55 293.48 Kb 316
17644 Mercola CFS 2022.pdf admin 22 May, 2022 22:36 116.47 Kb 271
17621 Mg Fibro review 2021.pdf PDF 2021 admin 19 May, 2022 10:30 381.41 Kb 277
14035 Impact of Fibromyalgia.pdf PDF 2020 admin 14 Jul, 2020 13:16 420.28 Kb 853
6197 Fibro Easy.jpg admin 30 Nov, 2015 03:05 75.09 Kb 54517
5032 Beyond CFS - IOM Feb 2015.pdf PDF 2015 admin 10 Feb, 2015 19:16 589.27 Kb 2287
4857 Pain level.jpg admin 11 Jan, 2015 15:47 49.55 Kb 33216
4856 Diganosis delay.jpg admin 11 Jan, 2015 14:38 58.53 Kb 34762
4462 Fibomyalgia.jpg admin 08 Oct, 2014 11:54 69.87 Kb 38896
4301 Overlap.jpg admin 20 Aug, 2014 12:04 61.41 Kb 70339
4300 Like me symptoms.jpg admin 20 Aug, 2014 11:58 30.29 Kb 34169
4299 Fibro survey comparison.jpg admin 20 Aug, 2014 11:17 45.43 Kb 39724
75 Patients Like Me Fibro.gif Patients Like Me CFS admin 10 Jun, 2010 02:44 28.17 Kb 8870