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Muscular Dystrophy probably treated by high-dose Vitamin D plus muscle rehab

Muscular Dystrophy treated by high dose Coimbra Protocol (Facebook Aug 2019)

" hi good people!
I almost don't enter facebook anymore, but as I started to report on the treatment with vitamin D (Coimbra Protocol), for muscular dystrophy, I couldn't help but report the results of the
I've been doing this treatment for EXACTLY 7 months, and as reported before, some enzymes in my body (CPK) were high, causing my muscles to become inflamed, consequently losing strength (this is the process of the disease)
But yesterday I got the results of the exams I did end of July, and guess
Below are the words of my doctor (Dr. Lucia Schaedler):
"your cpk and dhl that are muscle enzymes, are practically normal, indicating that thank god the inflammatory activity of your disease is stopped"

Imagine, lose strength for 17 years and receive such a news, that the disease is stabilized
Only God knows how happy I am with this, and I wanted to share with you this news, that were people who gave me so many words of support and love since I decided to report about this disease I

PS. With The Disease Stabilized, it does not mean that I will have the muscle strength I had before, and yes that I will not continue to lose, now is to do the next step: Physiotherapy to keep the muscles I have, and continue with the treatment But as for God, nothing is impossible, I will not stop believing that one day I can make my moves again

Thank you dr. Lucia for all dedication, attention and strength that is giving me! ❤️

So that's it... thank you all for the strength and as soon as I have more news, I'll

Fracture in Duchenne Muscular Dystrophy: Natural History and Vitamin D Deficiency – 2016

J Child Neurol. 2016 Aug;31(9):1181-7. doi: 10.1177/0883073816650034. Epub 2016 May 24.
Perera N1, Sampaio H2, Woodhead H3, Farrar M4.
1 Discipline of Paediatrics, School of Women's and Children's Health, UNSW Medicine, University of New South Wales, Sydney, Australia.
2 Department of Neurology, Sydney Children's Hospital, Randwick, Australia.
3 Discipline of Paediatrics, School of Women's and Children's Health, UNSW Medicine, University of New South Wales, Sydney, Australia Department of Endocrinology, Sydney Children's Hospital, Randwick, Australia.
4 Discipline of Paediatrics, School of Women's and Children's Health, UNSW Medicine, University of New South Wales, Sydney, Australia Department of Neurology, Sydney Children's Hospital, Randwick, Australia m.farrar at unsw.edu.au.

The present study examined the natural history of fracture and vitamin D levels in Duchenne muscular dystrophy patients, who are vulnerable to osteoporosis and fractures. Retrospective analysis of a cohort of 48 Duchenne muscular dystrophy patients revealed that 43% of patients experienced ≥1 fracture. Fracture probabilities at ages 6, 9, 12, and 15 years were 4%, 9%, 31%, and 60% respectively, accelerating around the time of ambulation loss (mean age 11.8 ± 2.7 years). Chronic corticosteroid therapy was utilized in 69% of patients and was associated with all vertebral fractures. A history of vitamin D deficiency occurred in 84%, and 35% were currently deficient. Despite chronic vitamin D supplementation, 38% remained deficient. These results demonstrate that osteoporosis and fracture remain major concerns in Duchenne muscular dystrophy. Bone health should be optimized well before loss of ambulation, however current levels of vitamin D supplementation may be inadequate given high levels of deficiency.

Increased Rates of Vitamin D Insufficiency in Boys With Duchenne Muscular Dystrophy Despite Higher Vitamin D3 Supplementation – 2019

Glob Pediatr Health. 2019 Mar 15;6:2333794X19835661. doi: 10.1177/2333794X19835661
Bian Q1, McAdam L2, Grynpas M3, Mitchell J1, Harrington J4.
 Download the PDF from VitaminDWiki

Vitamin D supplementation is important for many chronic pediatric conditions to help maintain bone health; however, there is little evidence about how disease-related factors affect vitamin D status. The objective was to compare 25-hydroxyvitamin D (25(OH)D) concentrations in 3 pediatric cohorts (Duchenne muscular dystrophy [DMD], systemic lupus erythematosus SLE, and osteogenesis imperfecta [OI]). In a retrospective study of 367 subjects, children with DMD had increased prevalence of vitamin D insufficiency (25% vs 14% [SLE] and 10% [OI], P = .002), despite higher vitamin D3 supplementation doses. Boys with DMD also had higher weight, fat mass, and lower lean mass percentage Z scores. DMD was associated with having higher rates of vitamin D insufficiency than other comparable pediatric chronic disease cohorts, the effect of which may be modulated by clinical factors such as increased adiposity. While corroboration of these results is needed given baseline differences between the patient groups, greater vitamin D supplementation doses may be required to achieve optimal serum 25(OH)D concentrations in boys with DMD.

DMD - 3X lower response to ~1600 IU Vitamin D supplementation
DMD, Duchenne muscular dystrophy;
OI, osteogenesis imperfecta;
SLE, systemic lupus erythematosus

This study was cited 22 times as of July 2023

Google Scholar

Limb girdle muscular dystrophy - perhaps caused by a poor gene - a treatment in 2023

The Atlantic Magazine July 2023
The enzyme is known as HMG-CoA reductase halts cholesterol production
Dysfunction in this enzyme causes muscle weakness from both limb girdle muscular dystrophy and statins.

What Are the Different Types of Muscular Dystrophy? May 2021

Muscular Dystrophy and genes

MD and genes

Reduced response to Vitamin D is often due to poor vitamin D genes, such as:
Possibly: Poor Genes ==> Low Vitamin D ==> muscular dystrophy
Unaware of if genes can be changed
The solution might be just give 2X more vitamin D - similar to obese

Sometimes a reduced response to Vitamin D is due to a drug being taken to treat a disease
Wonder if a child with poor MD genes would be less likely to get MD if they had lots of Vitamin D

MD describes a set of 30+ similar problems due to poor inherity genes - WikiPedia

  • "The word "dystrophy" comes from the Greek dys, meaning "no, un-" and troph- meaning "nourish""

DMD has very low D - thesis by Bian

 Download the PDF from VitaminDWiki
DMD insufficient but not deficient

DMD had far less response to Vitamin D

Mechanisms in Sarcopenia and Muscular Dystrophy - Aug 2015

Editorial: Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach
 Download the PDF from VitaminDWiki

Suspect that if MD is treated, that muscles growth will be helped by Sarcopenia techniques

VitaminDWiki - Multiple Sclerosis and Vitamin D ~ 50,000 Facebook members in 13 languages – Jan 2017

Life Extension Magazine Overview of Muscular Dystrophy - Dec 2020

Nutrients that help
Coenzyme Q10 (anti-oxident - sometimes combined with Vitamin D)
Resveratrol (ncreases Vitamin D in cells),
Creatine (builds muscles)
Omega-3 (builds muscles)
Vitamin D
Green tea
Vitamin E and Selenium (anti-oxidents)
N-acetylcysteine (antioxidant which decreases muscle damage)

VitaminDWiki - Overview Muscles and Vitamin D

95% of MD patients had low Vitamin D - 2019

Vitamin D in Patients With Duchenne Muscular Dystrophy   Free PDF
Question: Low D ==> MD,   MD ==> Low D,   or X ==> Low D and MD

VitaminDWiki – Autoimmune category contains

6X recent increase in DMD - increase which is typical of many autoimmune diseases

Patient demographics and characteristics from an ambispective, observational study of patients with duchenne muscular dystrophy in Saudi Arabia - Sept 2020
 Download the PDF from VitaminDWiki

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Attached files

ID Name Comment Uploaded Size Downloads
19834 MD types.webp admin 23 Jul, 2023 21:44 35.31 Kb 84
19364 Huge increase in MD.jpg admin 23 Mar, 2023 13:40 20.17 Kb 268
19363 duchenne muscular dystrophy in Saudi Arabia.pdf admin 23 Mar, 2023 13:37 769.56 Kb 98
19362 Pathophysiological mechanisms of sarcopenia.pdf admin 23 Mar, 2023 13:04 115.32 Kb 94
12491 Vit D per IU.jpg admin 16 Aug, 2019 01:49 36.36 Kb 1627
12489 DMD vit D thesis.jpg admin 16 Aug, 2019 01:49 46.88 Kb 1616
12488 Bian DMD thesis.pdf PDF 2019 admin 16 Aug, 2019 01:45 1.11 Mb 630
12485 DMD per IU.jpg admin 15 Aug, 2019 21:16 96.62 Kb 1668
12484 DMD 60 percent.jpg admin 15 Aug, 2019 21:16 19.44 Kb 1729
12483 Muscular Dystrophy 2019.pdf PDF 2019 admin 15 Aug, 2019 20:55 430.42 Kb 566