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Cancer Chemotherapy and vitamin D – Review March 2013

Vitamin D: Pharmacokinetics and Safety When Used in Conjunction with the Pharmaceutical Drugs Used in Cancer Patients: A Systematic Review

Cancers 2013, 5(1), 255-280; doi:10.3390/cancers5010255
Deborah A. Kennedy 1 , Kieran Cooley 1 , Becky Skidmore 1 Heidi Fritz 1 , Tara Campbell 1 email and Dugald Seely 1,2, dseely at ccnm.edu
1 Canadian College of Naturopathic Medicine, 1255 Sheppard Avenue East, Toronto, Ontario, M2K 1E2, Canada 2 Ottawa Integrative Cancer Centre, 29 Bayswater Avenue, Ottawa, Ontario, K1Y 2E5, Canada

Vitamin D has reported anti-cancer and anti-inflammatory properties modulated through gene transcription and non-genomic signaling cascades. The purpose of this review was to summarize the available research on interactions and pharmacokinetics between vitamin D and the pharmaceutical drugs used in patients with cancer. Hypercalcemia was the most frequently reported side effect that occurred in high dose calcitriol.

The half-life of 25(OH)D3 and/or 1,25(OH)2D3 was found to be impacted by cimetidine; rosuvastatin; prednisone and possibly some chemotherapy drugs.

No unusual adverse effects in cancer patients; beyond what is expected from high dose 1,25(OH)2D3 supplementation, were revealed through this review.

While sufficient evidence is lacking, supplementation with 1,25(OH)2D3 during chemotherapy appears to have a low risk of interaction. Further interactions with vitamin D3 have not been studied.

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Cancer Chemotherapy and vitamin D – Review March 2013

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- Overview Breast Cancer and Vitamin D Chemotherapy and vitamin D - many studies Chemotherapy (cisplatin) and vitamin D synergistically stop stomach cancer – Feb 2014 Both Vitamin D and Vitamin C fight cancers and aid anticancer drugs – May 2018 Chemotherapy might be augmented with Vitamin D – Jan 2017 Chemo reduced leukemia patients vitamin D levels – Jan 2013 Sore mouth due to cancer therapy (oral mucositis) substantially reduced by daily 1,000 IU of vitamin D – June 2017 Cancer treatment needs Vitamin D, Selenium, and other micronutrients – March 2016 Chemo drug (Nitrogen Mustard in this study) side effects minimized by vitamin D (mice) – March 2015 Radio frequency ablation survival doubled with even modest levels of vitamin D – Feb 2016 Off topic: Oncologists paid 350 dollars per patient-month to use less effective and more toxic cancer drugs – Oct 2014 20,000 IU weekly did not get 43 percent of Scottish Cancer patients to a level of 30 ng of vitamin D – April 2014

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Cancer - after diagnosis 108

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ID	Name	Comment	Uploaded	Size	Downloads
2191	Chemo A3.jpg		admin 12 Mar, 2013	66.84 Kb	2572
2190	Chemo and vitamin D.jpg		admin 12 Mar, 2013	46.40 Kb	2264
2189	cancers-05-00255.pdf	PDF	admin 12 Mar, 2013	617.25 Kb	859

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