Immune system and vitamin D, with emphasis on Inflammatory Bowel Disease – May 2022

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The Role of Vitamin D in Immune System and Inflammatory Bowel Disease

Journal of Inflammation Research Volume 2022:15 Pages 3167—3185 https://doi.org/10.2147/JIR.S363840
Wu Z , Liu D, Deng F Zengrong Wu,1,2 Deliang Liu,1,2 Feihong Deng1,2 dfh411 at csu.edu.cn
1Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, People’s Republic of China;
2Research Center of Digestive Disease, Central South University, Changsha, Hunan, 410011, People’s Republic of China

PDF Table of Contents

Chart: Immune system and Vitamin D

Chart Intestines, Vitamin D and immune system

Inflammatory bowel disease (IBD) is a nonspecific inflammatory disease that includes ulcerative colitis (UC) and Crohn’s disease (CD). The pathogenesis of IBD is not fully understood but is most reported associated with immune dysregulation, dysbacteriosis, genetic susceptibility, and environmental risk factors. Vitamin D is an essential nutrient for the human body, and it not only regulates bone metabolism but also the immune system, the intestinal microbiota and barrier. Vitamin D insufficiency is common in IBD patients, and the abnormal low levels of vitamin D are highly correlated with disease activity, treatment response, and risk of relapse of IBD. Accumulating evidence supports the protective role of vitamin D in IBD through regulating the adaptive and innate immunity, maintaining the intestinal barrier and balancing the gut microbiota. This report aims to provide a broad overview of the role vitamin D in the immune system, especially in the pathogenesis and treatment of IBD, and its possible role in predicting relapse.
 Download the PDF from VitaminDWiki

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VitaminDWiki pages with IBD or IBS in title (25 as of May 2022)

This list is automatically updated

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VitaminDWiki pages with CROHN in (35 as ofMay 2022)

This list is automatically updated

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VitaminDWiki - Overview Gut and vitamin D contains

• Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
• Celiac disease has a strong genetic component.
  • Most, but not all, people with celiac disease have a gene variant.
  • An adequate level vitamin D seems to decrease the probability of getting celiac disease.
  • Celiac disease causes poor absorption of nutrients such as vitamin D.
  • Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
  • The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
• Review in Nov 2013 found that Vitamin D helped
  Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
• All items in category gut and vitamin D 215 items

Along with gut-friendly information

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VitaminDWiki - Gut category contains

215 items in GUT category - see also Overview Gut and vitamin D,

• Ulcerative Colitis and Vitamin D - many studies 12+
• "celiac disease" OR CD 1830 items July 2019
• IBS or IBD or IRRITABLE BOWEL in title of 40 VitaminDWiki pages as of Jan 2025
• Gut-Friendly forms of vitamin D
  • such as: bio-emulsion, topical, spray, sublingual, inhaled, injection .

See also Microbiome category listing has 44 items along with related searches.

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VitaminDWiki - Immunity category contains

276 items in Immunity category

    see also

Virus category listing has 1412 items along with related searches

Overview Influenza and vitamin D
Vitamin D helps both the innate and adaptive immune systems fight COVID-19 – Jan 2022
Vitamin D aids the clearing out of old cells (autophagy) – many studies
600,000 IU of Vitamin D (total) allowed previously weak immune systems to fight off a virus antigen - Nov 2020
Search for treg OR "t-cell" in VitaminDWiki 1440 items as of Jan 2020
228 VitaminDWiki pages contained "infection" in title (June 2024)
Search VitaminDWik for BACTERIA in title 25 items as of Aug 2019
Vitamin D and the Immune System – chapter Aug 2019
7X less risk of influenza if Vitamin D levels higher than 30 ng – Oct 2017
Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
Vitamin D improves T Cell immunity – RCT Feb 2016
Immune system - great 11-minute animated video - Aug 2021
   Only the brain is more complex, nothing about Vitamin D
18 titles in VitaminDWiki contained INNATE or ADAPTIVE as of Jan 2023
Increasing publications on vitamin D and Infection

53 studies are in both Immunity and Virus categories

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Note: Gut-Friendly Vitamin D is far better for those with gut problems

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Note: A time-release vitamin D would probably be good for gut problems - but do not know of a supplier as of May 2022

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VitaminDWiki pages with Colitis in (15 as of May 2022)

This list is automatically updated

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Note: My spouse has very successfully used a nanoemulsion vitamin D to treat her colitis

She had severe attacks of ulcerative colitis many times a year for many decades
Adding oral vitamin D did not appear to help
Previously we had great success applying vitamin D directly to a problem
   gums, warts, burns, abrasions, etc.
We evolved ways to get vitamin d directly to this problem
Vitamin D powder added to water helped some when a teaspoon of it was inserted into the rectum
Adding salt to the water helped
100,0000 IU of nanoemulsion also was good
Ended up using 200,000 IU of nanoemulsion vitamin D in 1 pint of water with a "pinch" of - using about a tablespoon at a time
Similar attack frequency, but far less intense.
The problem goes away after 3 nightly applications