1 pill a day is better than multiple (probably 1 per 2 weeks would be even better) - RCT

How to Get Heart Patients to Take Their Pills? Give Them Just One - New York Times Aug 2022

NYT  "The participants also experienced one-third fewer cardiovascular deaths,"

Study: Polypill Strategy in Secondary Cardiovascular Prevention

New England Journal of Medicine DOI: 10.1056/NEJMoa2208275

Results

A total of 2499 patients underwent randomization and were followed for a median of 36 months. A primary-outcome event occurred in 118 of 1237 patients ( 9.5% ) in the polypill group and in 156 of 1229 ( 12.7% ) in the usual-care group (hazard ratio, 0.76; 95% confidence interval [CI], 0.60 to 0.96; P=0.02).

A key secondary-outcome event occurred in 101 patients (8.2%) in the polypill group and in 144 (11.7%) in the usual-care group ( hazard ratio, 0.70; 95% CI, 0.54 to 0.90; P=0.005). The results were consistent across prespecified subgroups. Medication adherence as reported by the patients was higher in the polypill group than in the usual-care group. Adverse events were similar between groups.

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See also VitaminDWiki

• One pill every two weeks gives you all the vitamin D most adults need

• Better than Daily

• Better compliance due to:

  • Fewer opportunities to forget

  • Fewer times to have to take a pill - for those who dislike it