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Ann Anderson-Berry, Melissa Thoene, Julie Wagner, Elizabeth Lyden, Glenville Jones, Martin Kaufmann, Matthew Van Ormer, Corrine Hanson
Randomized trial of two doses of vitamin D3 in preterm infants <32 weeks: Dose impact on achieving desired serum 25(OH)D3 in a NICU population
www.plosone.org
www.plosone.org
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0 Tc
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-0.004 Tc
(1500)Tj
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2.2847 0 Td
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(10)Tj
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(trial)Tj
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(evalu-)Tj
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(200)Tj
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1.7291 0 Td
(800)Tj
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(36)Tj
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(800)Tj
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2.0013 0 Td
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1.4683 0 Td
(200)Tj
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4.2406 0 Td
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1.0261 0 Td
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3.5036 0 Td
(but)Tj
1.5534 0 Td
(no)Tj
1.2756 0 Td
(dif-)Tj
-35.8013 -1.2983 Td
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3.118 0 Td
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1.0375 0 Td
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1.9956 0 Td
(alive)Tj
2.0466 0 Td
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1.0998 0 Td
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1.0375 0 Td
(respiratory)Tj
4.5921 0 Td
(support)Tj
3.3222 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(].)Tj
-17.0531 -1.3039 Td
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5.0853 0 Td
(levels)Tj
2.3641 0 Td
(of)Tj
1.0034 0 Td
(25\(OH\)D)Tj
4.0932 0 Td
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2.9991 0 Td
(than)Tj
2.0239 0 Td
(50)Tj
1.1622 0 Td
(nmol/l)Tj
2.9083 0 Td
(have)Tj
2.0466 0 Td
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-33.2331 -1.2983 Td
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(rickets)Tj
2.8574 0 Td
(in)Tj
1.0374 0 Td
(infants)Tj
2.965 0 Td
(and)Tj
1.7292 0 Td
(children,)Tj
3.7814 0 Td
(a)Tj
0.6576 0 Td
(disease)Tj
3.016 0 Td
(of)Tj
1.0148 0 Td
(extreme)Tj
3.4469 0 Td
(nutritional)Tj
4.5354 0 Td
(deficiency.)Tj
4.4901 0 Td
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1.2642 0 Td
(the)Tj
1.4684 0 Td
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1.7688 0 Td
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-35.0473 -1.2983 Td
(vitamin)Tj
3.3108 0 Td
(D)Tj
0.9524 0 Td
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3.6283 0 Td
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4.5977 0 Td
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(allergy)Tj
2.863 0 Td
(and)Tj
1.7291 0 Td
(atopic)Tj
2.6702 0 Td
(disease,)Tj
3.2428 0 Td
(and)Tj
1.7291 0 Td
(many)Tj
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-34.9906 -1.3039 Td
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1.7348 0 Td
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3.9855 0 Td
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3.685 0 Td
(apparent,)Tj
3.9912 0 Td
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5.0796 0 Td
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2.058 0 Td
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4.0762 0 Td
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-32.7682 -1.2982 Td
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2.7212 0 Td
(level)Tj
2.0126 0 Td
(of)Tj
1.0148 0 Td
(25\(OH\)D)Tj
4.1045 0 Td
([)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(].)Tj
3.5433 0 Td
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2.9594 0 Td
(literature)Tj
3.8834 0 Td
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2.2053 0 Td
(adult,)Tj
2.4775 0 Td
(pediatric)Tj
3.753 0 Td
(and)Tj
1.7292 0 Td
(neonatal)Tj
3.6623 0 Td
(popula-)Tj
-34.0665 -1.2983 Td
(tions)Tj
2.1996 0 Td
(demonstrate)Tj
5.2327 0 Td
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4.1103 0 Td
(outcomes)Tj
4.0875 0 Td
(such)Tj
2.0579 0 Td
(as)Tj
1.0148 0 Td
(normalization)Tj
5.8847 0 Td
(of)Tj
1.0148 0 Td
(PTH)Tj
2.1543 0 Td
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0.9525 0 Td
(levels)Tj
/F10 1 Tf
0 Tc
2.3754 0 Td
(>)Tj
/F7 1 Tf
-0.004 Tc
(75)Tj
1.9445 0 Td
(nmol/l)Tj
-33.029 -1.3039 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(].)Tj
1.1962 -1.2983 Td
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0.8617 0 Td
(is)Tj
0.8447 0 Td
(likely)Tj
2.3584 0 Td
(that)Tj
1.7745 0 Td
(preterm)Tj
3.4469 0 Td
(infants)Tj
2.965 0 Td
(will)Tj
1.6668 0 Td
(have)Tj
2.0579 0 Td
(a)Tj
0.652 0 Td
(compromised)Tj
5.7656 0 Td
(vitamin)Tj
3.3109 0 Td
(D)Tj
0.9581 0 Td
(status)Tj
2.5001 0 Td
(at)Tj
0.9524 0 Td
(birth.)Tj
2.4152 0 Td
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-33.7264 -1.2983 Td
(studies)Tj
2.9876 0 Td
(in)Tj
1.0319 0 Td
(the)Tj
1.4683 0 Td
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3.0217 0 Td
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2.5115 0 Td
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1.7291 0 Td
(abroad)Tj
3.0047 0 Td
(have)Tj
2.058 0 Td
(documented)Tj
5.2497 0 Td
(maternal)Tj
3.7927 0 Td
(status)Tj
2.5002 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1508 0 Td
(suboptimal)Tj
-31.5323 -1.2982 Td
(and)Tj
1.7291 0 Td
(have)Tj
2.0579 0 Td
(called)Tj
2.5228 0 Td
(for)Tj
1.389 0 Td
(national)Tj
3.5036 0 Td
(programs)Tj
4.0649 0 Td
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1.0261 0 Td
(improve)Tj
3.5773 0 Td
(maternal)Tj
3.7984 0 Td
(vitamin)Tj
3.3108 0 Td
(D)Tj
0.9525 0 Td
(status)Tj
2.5001 0 Td
(with)Tj
2.0013 0 Td
(increased)Tj
-32.4338 -1.3039 Td
(supplementation)Tj
6.9561 0 Td
(dose)Tj
2.041 0 Td
(and)Tj
1.7291 0 Td
(frequency)Tj
4.1896 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
(].)Tj
3.5432 0 Td
(The)Tj
1.7802 0 Td
(fetus)Tj
2.1203 0 Td
(relies)Tj
2.3131 0 Td
(solely)Tj
2.4604 0 Td
(on)Tj
1.2756 0 Td
(maternal)Tj
3.7927 0 Td
(stores)Tj
2.5455 0 Td
(for)Tj
-34.7468 -1.2983 Td
(vitamin)Tj
3.3108 0 Td
(D)Tj
0.9524 0 Td
(in)Tj
1.0375 0 Td
(utero,)Tj
2.5738 0 Td
(and)Tj
1.7292 0 Td
(typically)Tj
3.5603 0 Td
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1.542 0 Td
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2.0523 0 Td
(blood)Tj
2.5171 0 Td
(levels)Tj
2.3698 0 Td
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5.9754 0 Td
(5075%)Tj
3.4015 0 Td
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1.0148 0 Td
(the)Tj
1.4684 0 Td
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-33.5053 -1.2983 Td
(value)Tj
2.3073 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(27)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(28)Tj
0 g
(].)Tj
3.9515 0 Td
(Bodnar)Tj
3.1861 0 Td
(showed)Tj
3.2542 0 Td
(as)Tj
1.0148 0 Td
(few)Tj
1.6157 0 Td
(as)Tj
1.0148 0 Td
(4.1%)Tj
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(of)Tj
1.0148 0 Td
(black)Tj
2.3244 0 Td
(and)Tj
1.7291 0 Td
(37.3%)Tj
2.6306 0 Td
(of)Tj
1.0148 0 Td
(term)Tj
2.1373 0 Td
(white)Tj
2.4208 0 Td
(infants)Tj
2.965 0 Td
(having)Tj
-34.7355 -1.3039 Td
(adequate)Tj
3.7927 0 Td
(\()Tj
/F10 1 Tf
0 Tc
(>)Tj
/F7 1 Tf
-0.004 Tc
(80)Tj
2.2847 0 Td
(nmol/l\))Tj
3.2598 0 Td
(levels)Tj
2.3698 0 Td
(at)Tj
0.9524 0 Td
(delivery,)Tj
3.617 0 Td
(while)Tj
2.3697 0 Td
(McCarthy)Tj
4.286 0 Td
(showed)Tj
3.2485 0 Td
(78%)Tj
1.9275 0 Td
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1.0148 0 Td
(infants)Tj
2.965 0 Td
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(lower)Tj
-35.1777 -1.2982 Td
(than)Tj
2.0295 0 Td
(optimal)Tj
3.3052 0 Td
(levels)Tj
2.3754 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(29)Tj
0 g
(].)Tj
3.2542 0 Td
(Importantly,)Tj
5.2837 0 Td
(several)Tj
2.931 0 Td
(studies)Tj
2.9877 0 Td
(have)Tj
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(documented)Tj
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(an)Tj
1.2019 0 Td
(association)Tj
4.6261 0 Td
(with)Tj
-35.3024 -1.2983 Td
(decreasing)Tj
4.4617 0 Td
(25\(OH\)D)Tj
4.1045 0 Td
(levels)Tj
2.3754 0 Td
(and)Tj
1.7291 0 Td
(lower)Tj
2.4548 0 Td
(gestational)Tj
4.5014 0 Td
(age)Tj
1.5421 0 Td
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0.9524 0 Td
(delivery)Tj
3.3902 0 Td
(allowing)Tj
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(a)Tj
0.6519 0 Td
(situation)Tj
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(where)Tj
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(preterm)Tj
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(infants)Tj
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(a)Tj
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(highly)Tj
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(vulnerable)Tj
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(population)Tj
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(at)Tj
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(birth)Tj
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(with)Tj
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(regards)Tj
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(to)Tj
1.0262 0 Td
(their)Tj
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(vitamin)Tj
3.3109 0 Td
(D)Tj
0.9524 0 Td
(sta-)Tj
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(tus)Tj
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([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(28)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(30)Tj
0 g
(].)Tj
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(Vitamin)Tj
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(D)Tj
0.9524 0 Td
(intake)Tj
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(during)Tj
2.9311 0 Td
(the)Tj
1.4683 0 Td
(first)Tj
1.8028 0 Td
(year)Tj
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1.0941 0 Td
(formula)Tj
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(and)Tj
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(supplemental)Tj
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(foods)Tj
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(not)Tj
1.5761 0 Td
(been)Tj
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(shown)Tj
2.8459 0 Td
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1.0262 0 Td
(consistently)Tj
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(equal)Tj
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(400)Tj
1.6441 0 Td
(IU/day,)Tj
3.2711 0 Td
(the)Tj
1.4684 0 Td
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(recommended)Tj
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(the)Tj
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(AAP)Tj
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(or)Tj
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(the)Tj
1.4683 0 Td
(IOM)Tj
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(term)Tj
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(infants)Tj
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([)Tj
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(31)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(32)Tj
0 g
(].)Tj
3.2542 0 Td
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3.4865 0 Td
(infants)Tj
2.9651 0 Td
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(size,)Tj
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(decreased)Tj
4.1328 0 Td
(volume)Tj
3.2032 0 Td
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(compromised)Tj
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(hospitalization)Tj
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3.7928 0 Td
(vitamin)Tj
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(intake)Tj
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(from)Tj
2.2054 0 Td
(diet)Tj
1.7348 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(].)Tj
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1.8708 0 Td
(objective)Tj
3.7814 0 Td
(with)Tj
1.9956 0 Td
(this)Tj
1.6724 0 Td
(double)Tj
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(blinded,)Tj
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(randomized)Tj
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(controlled)Tj
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(trial)Tj
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(evaluate)Tj
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(the)Tj
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(effects)Tj
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(of)Tj
1.0148 0 Td
(two)Tj
1.7064 0 Td
(different)Tj
3.6567 0 Td
(doses)Tj
2.3981 0 Td
(\(400)Tj
1.9899 0 Td
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1.2926 0 Td
(vs)Tj
1.0374 0 Td
(800)Tj
1.6498 0 Td
(IU\))Tj
1.6327 0 Td
(of)Tj
1.0148 0 Td
(vitamin)Tj
3.3109 0 Td
(D)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 441.6944 159.7606 cm
BT
/F7 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(3)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 447.4204 161.4047 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(on)Tj
1.2755 0 Td
(a)Tj
0.6577 0 Td
(preterm)Tj
3.4412 0 Td
(patient)Tj
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(population)Tj
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1.3833 0 Td
(the)Tj
1.474 0 Td
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3.6964 0 Td
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