%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Ronaldo D. Piovezan, Camila Hirotsu, Marcia C. Feres, Fatima D. Cintra, Monica L. Andersen, Sergio Tufik, Dalva Poyares
Obstructive sleep apnea and objective short sleep duration are independently associated with the risk of serum vitamin D deficiency
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 13 0 R/Contents 14 0 R/TrimBox[0 0 612 792]>>
endobj
13 0 obj
[15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R]
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpone.0180901.ref001)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0180901.ref002)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0180901.ref002)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0180901.ref004)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0180901.ref005)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0180901.ref006)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0180901.ref007)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0180901.ref008)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0180901.ref009)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0180901.ref010)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0180901.ref010)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0180901.ref012)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0180901.ref013)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpone.0180901.ref014)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpone.0180901.ref015)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpone.0180901.ref016)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpone.0180901.ref017)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpone.0180901.ref018)>>
endobj
33 0 obj
<>/Border[0 0 0]/A 39 0 R>>
endobj
39 0 obj
<>
endobj
34 0 obj
<>/Border[0 0 0]/A 40 0 R>>
endobj
40 0 obj
<>
endobj
35 0 obj
<>/Border[0 0 0]/A 41 0 R>>
endobj
41 0 obj
<>
endobj
36 0 obj
<>/Border[0 0 0]/A 42 0 R>>
endobj
42 0 obj
<>
endobj
37 0 obj
<>/Border[0 0 0]/A 43 0 R>>
endobj
43 0 obj
<>
endobj
38 0 obj
<>/Border[0 0 0]/A 44 0 R>>
endobj
44 0 obj
<>
endobj
14 0 obj
[45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R]
endobj
45 0 obj
<>stream
q
0.45 0.36 0.35 0.01 k
0 w
575.9997 619.9101 m
199.9998 619.9101 l
199.9998 620.4101 l
575.9997 620.4101 l
f*
0.83 0.64 0.02 0 k
421.0583 522.3685 m
425.8205 522.3685 l
h
f*
323.8866 496.4031 m
328.6488 496.4031 l
h
f*
203.4142 457.3984 m
208.1764 457.3984 l
h
f*
213.3354 457.3984 m
218.0976 457.3984 l
h
f*
394.6961 444.3591 m
399.4583 444.3591 l
h
f*
410.6835 444.3591 m
415.4457 444.3591 l
h
f*
413.1213 418.3937 m
417.8835 418.3937 l
h
f*
429.1087 418.3937 m
433.8709 418.3937 l
h
f*
497.0268 418.3937 m
501.789 418.3937 l
h
f*
513.0709 418.3937 m
522.5953 418.3937 l
h
f*
531.8929 392.3717 m
541.4173 392.3717 l
h
f*
546.5764 392.3717 m
556.1008 392.3717 l
h
f*
541.5874 353.3669 m
551.1118 353.3669 l
h
f*
562.3937 353.3669 m
571.8614 353.3669 l
h
f*
260.9008 327.4016 m
270.4252 327.4016 l
h
f*
281.7071 327.4016 m
291.1748 327.4016 l
h
f*
493.285 314.3622 m
502.8094 314.3622 l
h
f*
326.3244 288.3969 m
335.8488 288.3969 l
h
f*
0 g
1 j
1 J
11.4998 0 0 11.4998 200.0125 706.3937 cm
BT
/F2 1 Tf
1 TL
-0.0035 Tc
0 0 Td
(Conclusion)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 200.0125 689.3858 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(OSA)Tj
2.3214 0 Td
(and)Tj
1.8678 0 Td
(short)Tj
2.4229 0 Td
(sleep)Tj
2.578 0 Td
(duration)Tj
3.7835 0 Td
(are)Tj
1.6471 0 Td
(independently)Tj
6.3615 0 Td
(associated)Tj
4.9472 0 Td
(with)Tj
1.9753 0 Td
(the)Tj
1.5934 0 Td
(risk)Tj
1.7604 0 Td
(of)Tj
1.0444 0 Td
(25\(OH\)D)Tj
4.1893 0 Td
(defi-)Tj
-36.4922 -1.474 Td
(ciency)Tj
3.0196 0 Td
(in)Tj
0.9846 0 Td
(an)Tj
1.3189 0 Td
(adult)Tj
2.3572 0 Td
(population.)Tj
5.0427 0 Td
(Age-related)Tj
5.3291 0 Td
(changes)Tj
3.9566 0 Td
(in)Tj
0.9846 0 Td
(vitamin)Tj
3.3538 0 Td
(D)Tj
0.931 0 Td
(metabolism)Tj
5.2814 0 Td
(and)Tj
1.8679 0 Td
(the)Tj
1.5933 0 Td
(fre-)Tj
-36.0207 -1.468 Td
(quency)Tj
3.4075 0 Td
(of)Tj
1.0443 0 Td
(sleep)Tj
2.578 0 Td
(disorders)Tj
4.2848 0 Td
(may)Tj
2.0947 0 Td
(be)Tj
1.3188 0 Td
(involved)Tj
3.8372 0 Td
(in)Tj
0.9847 0 Td
(these)Tj
2.6377 0 Td
(associations.)Tj
5.9318 0 Td
(Future)Tj
3.0853 0 Td
(studies)Tj
3.3538 0 Td
(exploring)Tj
-34.5586 -1.474 Td
(whether)Tj
3.7357 0 Td
(25\(OH\)D)Tj
4.1893 0 Td
(levels)Tj
2.7392 0 Td
(may)Tj
2.0946 0 Td
(modulate)Tj
4.2848 0 Td
(OSA)Tj
2.3274 0 Td
(and)Tj
1.8678 0 Td
(sleep)Tj
2.5721 0 Td
(curtailment-relat)Tj
7.0896 0 Td
(ed)Tj
1.3188 0 Td
(outcomes)Tj
4.5116 0 Td
(are)Tj
-36.7309 -1.474 Td
(needed.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 553.4362 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 536.4283 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Apart)Tj
2.5228 0 Td
(from)Tj
2.2053 0 Td
(bone)Tj
2.2053 0 Td
(homeostasis,)Tj
5.3121 0 Td
(vitamin)Tj
3.3109 0 Td
(D)Tj
0.9581 0 Td
(\(25\(OH\)D\))Tj
4.7792 0 Td
(has)Tj
1.542 0 Td
(been)Tj
2.126 0 Td
(implicated)Tj
4.4447 0 Td
(in)Tj
1.0318 0 Td
(an)Tj
1.2075 0 Td
(increasing)Tj
-31.6457 -1.2982 Td
(number)Tj
3.4185 0 Td
(of)Tj
1.0148 0 Td
(physiological)Tj
5.4425 0 Td
(mechanisms,)Tj
5.4311 0 Td
(including)Tj
4.0422 0 Td
(sleep.)Tj
2.4151 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(])Tj
1.3777 0 Td
(Several)Tj
3.05 0 Td
(studies)Tj
2.982 0 Td
(have)Tj
2.0636 0 Td
(identified)Tj
4.0592 0 Td
(vita-)Tj
-35.2967 -1.2983 Td
(min)Tj
1.8538 0 Td
(D)Tj
0.9581 0 Td
(receptors)Tj
3.9175 0 Td
(\(VDR\))Tj
2.948 0 Td
(in)Tj
1.0374 0 Td
(nearly)Tj
2.6986 0 Td
(all)Tj
1.1452 0 Td
(tissues)Tj
2.8233 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(body,)Tj
2.4378 0 Td
(including)Tj
4.0422 0 Td
(both)Tj
2.0579 0 Td
(neuronal)Tj
3.8267 0 Td
(and)Tj
1.7348 0 Td
(glial)Tj
1.8766 0 Td
(cells)Tj
-35.8637 -1.2982 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(central)Tj
2.965 0 Td
(nervous)Tj
3.4129 0 Td
(system.)Tj
3.1634 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(])Tj
1.3776 0 Td
(VDR)Tj
2.2677 0 Td
(are)Tj
1.4514 0 Td
(present)Tj
3.1634 0 Td
(in)Tj
1.0375 0 Td
(multiple)Tj
3.566 0 Td
(areas)Tj
2.245 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(human)Tj
3.0784 0 Td
(brain,)Tj
-32.7172 -1.304 Td
(including)Tj
4.0421 0 Td
(the)Tj
1.4684 0 Td
(prefrontal)Tj
4.2236 0 Td
(cortex,)Tj
2.9366 0 Td
(cingulate)Tj
3.8551 0 Td
(gyrus,)Tj
2.6249 0 Td
(thalamus,)Tj
4.0932 0 Td
(substantia)Tj
4.2576 0 Td
(nigra,)Tj
2.5285 0 Td
(hippocampus,)Tj
-30.03 -1.2982 Td
(and)Tj
1.7234 0 Td
(also)Tj
1.7575 0 Td
(the)Tj
1.4626 0 Td
(hypothalamus,)Tj
6.0945 0 Td
(a)Tj
0.6463 0 Td
(brain)Tj
2.3414 0 Td
(area)Tj
1.8708 0 Td
(that)Tj
1.7745 0 Td
(regulates)Tj
3.7644 0 Td
(sleep-wake)Tj
4.5694 0 Td
(cycle)Tj
2.1827 0 Td
(among)Tj
2.9877 0 Td
(other)Tj
2.3414 0 Td
(behaviors.)Tj
-33.5166 -1.2983 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(])Tj
2.3697 0 Td
(Moreover,)Tj
4.3937 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(last)Tj
1.559 0 Td
(decade,)Tj
3.2032 0 Td
(studies)Tj
2.9877 0 Td
(reporting)Tj
3.9911 0 Td
(associations)Tj
4.989 0 Td
(between)Tj
3.5262 0 Td
(sleep)Tj
2.194 0 Td
(disorders)Tj
3.9345 0 Td
(and)Tj
-35.6539 -1.3039 Td
(lower)Tj
2.4491 0 Td
(levels)Tj
2.3754 0 Td
(of)Tj
1.0148 0 Td
(25\(OH\)D)Tj
4.1045 0 Td
(increased)Tj
3.9968 0 Td
(consistently.)Tj
5.1874 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(],)Tj
1.5987 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(])Tj
-19.5305 -1.2983 Td
(Particularly,)Tj
5.0796 0 Td
(obstructive)Tj
4.6601 0 Td
(sleep)Tj
2.194 0 Td
(apnea)Tj
2.5739 0 Td
(\(OSA\))Tj
2.8063 0 Td
(shares)Tj
2.6985 0 Td
(relevant)Tj
3.4243 0 Td
(risk)Tj
1.7121 0 Td
(factors)Tj
2.9026 0 Td
(with)Tj
2.0013 0 Td
(25\(OH\)D)Tj
4.0989 0 Td
(defi-)Tj
-35.3478 -1.2982 Td
(cit,)Tj
1.4343 0 Td
(such)Tj
2.0579 0 Td
(as)Tj
1.0148 0 Td
(age,)Tj
1.7688 0 Td
(obesity,)Tj
3.2655 0 Td
(hypertension,)Tj
5.6919 0 Td
(kidney)Tj
2.9367 0 Td
(disease[)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(],)Tj
4.3994 0 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(])Tj
1.3776 0 Td
(and)Tj
1.7291 0 Td
(diabetes.)Tj
3.6907 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(],)Tj
1.5987 0 Td
([)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(])Tj
1.8482 0 Td
(OSA)Tj
2.1316 0 Td
(has)Tj
-34.9452 -1.304 Td
(also)Tj
1.7688 0 Td
(been)Tj
2.1203 0 Td
(linked)Tj
2.7325 0 Td
(to)Tj
1.0205 0 Td
(reduced)Tj
3.4469 0 Td
(levels)Tj
2.3754 0 Td
(of)Tj
1.0148 0 Td
(25\(OH\)D,)Tj
4.3257 0 Td
(as)Tj
1.0148 0 Td
(this)Tj
1.6781 0 Td
(sleep)Tj
2.1883 0 Td
(disorder)Tj
3.5773 0 Td
(leads)Tj
2.211 0 Td
(to)Tj
1.0261 0 Td
(sleep)Tj
2.194 0 Td
(fragmenta-)Tj
-32.6945 -1.2982 Td
(tion)Tj
1.8425 0 Td
(and)Tj
1.7291 0 Td
(daytime)Tj
3.4412 0 Td
(sleepiness,)Tj
4.3824 0 Td
(which)Tj
2.6475 0 Td
(might)Tj
2.5965 0 Td
(increase)Tj
3.4753 0 Td
(the)Tj
1.4683 0 Td
(risk)Tj
1.7178 0 Td
(of)Tj
1.0148 0 Td
(vitamin)Tj
3.3052 0 Td
(D)Tj
0.9581 0 Td
(deficiency)Tj
4.2689 0 Td
([)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(].)Tj
3.5433 0 Td
(In)Tj
-36.3909 -1.2983 Td
(fact,)Tj
1.8878 0 Td
(more)Tj
2.3414 0 Td
(recently,)Tj
3.634 0 Td
(Liguori)Tj
3.1635 0 Td
(et)Tj
0.941 0 Td
(al.)Tj
1.1282 0 Td
(have)Tj
2.058 0 Td
(found)Tj
2.6192 0 Td
(that)Tj
1.7801 0 Td
(continuous)Tj
4.7338 0 Td
(positive)Tj
3.3166 0 Td
(airway)Tj
2.8686 0 Td
(pressure)Tj
3.5773 0 Td
(\(CPAP\))Tj
-34.0495 -1.3039 Td
(has)Tj
1.542 0 Td
(an)Tj
1.2019 0 Td
(impact)Tj
2.982 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(vitamin)Tj
3.3109 0 Td
(D)Tj
0.9524 0 Td
(homeostasis)Tj
5.091 0 Td
(of)Tj
1.0148 0 Td
(male)Tj
2.143 0 Td
(OSA)Tj
2.1259 0 Td
(patients,)Tj
3.5943 0 Td
(reinforcing)Tj
4.6999 0 Td
(a)Tj
0.6519 0 Td
(potential)Tj
-32.0539 -1.2983 Td
(causal)Tj
2.6475 0 Td
(relationship)Tj
4.9889 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4684 0 Td
(association)Tj
4.6318 0 Td
(between)Tj
3.5262 0 Td
(OSA)Tj
2.126 0 Td
(and)Tj
1.7348 0 Td
(lower)Tj
2.4491 0 Td
(levels)Tj
2.3754 0 Td
(of)Tj
1.0148 0 Td
(this)Tj
1.6725 0 Td
(hormone.)Tj
4.1499 0 Td
([)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(],)Tj
2.0806 0 Td
([)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(])Tj
-35.8977 -1.2982 Td
(Likewise,)Tj
3.9061 0 Td
(subjectively)Tj
4.8642 0 Td
(measured)Tj
4.1045 0 Td
(short)Tj
2.2904 0 Td
(sleep)Tj
2.1883 0 Td
(duration)Tj
3.7021 0 Td
(has)Tj
1.542 0 Td
(also)Tj
1.7688 0 Td
(been)Tj
2.1203 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
2.0013 0 Td
(lower)Tj
2.4491 0 Td
(25)Tj
-35.1947 -1.2983 Td
(\(OH\)D)Tj
3.1521 0 Td
(levels.)Tj
2.5965 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(],)Tj
2.0806 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(])Tj
1.8482 0 Td
(Additionally,)Tj
5.4538 0 Td
(recent)Tj
2.7099 0 Td
(evidence)Tj
3.7134 0 Td
(suggested)Tj
4.0705 0 Td
(a)Tj
0.6576 0 Td
(relationship)Tj
4.989 0 Td
(between)Tj
3.5262 0 Td
(objec-)Tj
-34.7978 -1.3039 Td
(tive)Tj
1.661 0 Td
(short)Tj
2.2848 0 Td
(sleep)Tj
2.1883 0 Td
(duration)Tj
3.702 0 Td
(\(measured)Tj
4.4504 0 Td
(by)Tj
1.1792 0 Td
(actigraphy\))Tj
4.7508 0 Td
(and)Tj
1.7291 0 Td
(25\(OH\)D)Tj
4.0989 0 Td
(deficit.)Tj
2.9424 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(])Tj
1.8481 0 Td
(In)Tj
1.1112 0 Td
(a)Tj
0.652 0 Td
(multi-ethnic)Tj
-32.5982 -1.2983 Td
(study,)Tj
2.6135 0 Td
(similar)Tj
2.9877 0 Td
(results)Tj
2.8063 0 Td
(toward)Tj
3.0443 0 Td
(reduced)Tj
3.447 0 Td
(actigraphy-measured)Tj
8.6512 0 Td
(sleep)Tj
2.1884 0 Td
(duration)Tj
3.702 0 Td
(in)Tj
1.0375 0 Td
(those)Tj
2.3357 0 Td
(with)Tj
2.0012 0 Td
(defi-)Tj
-34.8148 -1.2982 Td
(cient)Tj
2.1769 0 Td
(25\(OH\)D)Tj
4.1046 0 Td
(were)Tj
2.1203 0 Td
(reported.)Tj
3.8891 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(])Tj
-11.0947 -1.304 Td
(However,)Tj
4.0818 0 Td
(taken)Tj
2.4208 0 Td
(together)Tj
3.5319 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.474 0 Td
(current)Tj
3.1805 0 Td
(evidence,)Tj
3.9401 0 Td
(it)Tj
0.7824 0 Td
(is)Tj
0.8504 0 Td
(still)Tj
1.6384 0 Td
(not)Tj
1.576 0 Td
(possible)Tj
3.4073 0 Td
(to)Tj
1.0261 0 Td
(conclude)Tj
3.8494 0 Td
(if)Tj
-34.9509 -1.2982 Td
(there)Tj
2.262 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.6519 0 Td
(confounding)Tj
5.3802 0 Td
(or)Tj
1.0998 0 Td
(modifying)Tj
4.3653 0 Td
(effect)Tj
2.3641 0 Td
(of)Tj
1.0148 0 Td
(a\))Tj
0.9921 0 Td
(reduced)Tj
3.4469 0 Td
(sleep)Tj
2.1884 0 Td
(duration)Tj
3.702 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(association)Tj
-31.0618 -1.2983 Td
(between)Tj
3.5262 0 Td
(OSA)Tj
2.126 0 Td
(and)Tj
1.7291 0 Td
(lower)Tj
2.4548 0 Td
(25\(OH\)D;)Tj
4.3257 0 Td
(b\))Tj
1.0658 0 Td
(OSA)Tj
2.1316 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(relationship)Tj
4.989 0 Td
(between)Tj
3.5263 0 Td
(short)Tj
2.2847 0 Td
(sleep)Tj
2.194 0 Td
(duration)Tj
-33.0971 -1.3039 Td
(and)Tj
1.7291 0 Td
(lower)Tj
2.4548 0 Td
(25\(OH\)D.)Tj
4.3256 0 Td
(Thus,)Tj
2.4718 0 Td
(we)Tj
1.3266 0 Td
(hypothesized)Tj
5.4708 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(current)Tj
3.1805 0 Td
(study)Tj
2.3924 0 Td
(that)Tj
1.7802 0 Td
(both)Tj
2.0579 0 Td
(sleep)Tj
2.194 0 Td
(quality)Tj
2.9537 0 Td
(and)Tj
-34.8432 -1.2983 Td
(quantity)Tj
3.5546 0 Td
(would)Tj
2.7099 0 Td
(be)Tj
1.1508 0 Td
(able)Tj
1.8312 0 Td
(to)Tj
1.0261 0 Td
(influence)Tj
3.9175 0 Td
(25\(OH\)D.)Tj
4.3256 0 Td
(Therefore,)Tj
4.3937 0 Td
(this)Tj
1.6724 0 Td
(study)Tj
2.3925 0 Td
(aimed)Tj
2.6929 0 Td
(to)Tj
1.0261 0 Td
(investigate)Tj
-30.6933 -1.2982 Td
(whether)Tj
3.4752 0 Td
(OSA)Tj
2.126 0 Td
(and)Tj
1.7291 0 Td
(short)Tj
2.2847 0 Td
(sleep)Tj
2.194 0 Td
(duration)Tj
3.702 0 Td
(measured)Tj
4.1102 0 Td
(by)Tj
1.1792 0 Td
(polysomnography)Tj
7.4608 0 Td
(\(PSG\))Tj
2.6475 0 Td
(are)Tj
1.4514 0 Td
(indepen-)Tj
-32.3601 -1.2983 Td
(dently)Tj
2.7155 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
2.0013 0 Td
(the)Tj
1.4683 0 Td
(risk)Tj
1.7121 0 Td
(of)Tj
1.0148 0 Td
(serum)Tj
2.7269 0 Td
(25\(OH\)D)Tj
4.0989 0 Td
(deficiency)Tj
4.269 0 Td
(in)Tj
1.0374 0 Td
(an)Tj
1.2019 0 Td
(adult)Tj
2.2507 0 Td
(sample)Tj
3.0217 0 Td
(of)Tj
1.0148 0 Td
(Sao)Tj
1.6384 0 Td
(Paulo,)Tj
-34.4293 -1.3039 Td
(Brazil.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 144 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Methods)Tj
/F0 1 Tf
0 -1.5023 Td
(Data)Tj
2.3102 0 Td
(source)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 109.0204 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(current)Tj
3.1861 0 Td
(study)Tj
2.3868 0 Td
(is)Tj
0.8504 0 Td
(part)Tj
1.8425 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(ERA)Tj
2.092 0 Td
(project,)Tj
3.2484 0 Td
(an)Tj
1.2019 0 Td
(observational)Tj
5.5786 0 Td
(study)Tj
2.3867 0 Td
(conducted)Tj
4.4277 0 Td
(in)Tj
1.0375 0 Td
(Sao)Tj
1.6384 0 Td
(Paulo,)Tj
-34.1402 -1.3039 Td
(Brazil,)Tj
2.7552 0 Td
(in)Tj
1.0375 0 Td
(which)Tj
2.6475 0 Td
(individuals)Tj
4.6488 0 Td
(with)Tj
2.0013 0 Td
(and)Tj
1.7291 0 Td
(without)Tj
3.3278 0 Td
(OSA)Tj
2.126 0 Td
(were)Tj
2.126 0 Td
(cross-sectionally)Tj
6.8031 0 Td
(assessed)Tj
3.4696 0 Td
(to)Tj
1.0261 0 Td
(stratify)Tj
-33.698 -1.2982 Td
(potential)Tj
3.7587 0 Td
(socio-demographic,)Tj
8.1467 0 Td
(clinical,)Tj
3.2995 0 Td
(laboratory)Tj
4.354 0 Td
(and)Tj
1.7291 0 Td
(image)Tj
2.6305 0 Td
(data)Tj
1.9106 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9956 0 Td
(OSA.)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 260.9007 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Obstructive)Tj
5.2016 0 Td
(sleep)Tj
2.5653 0 Td
(apnea)Tj
2.9481 0 Td
(and)Tj
1.8567 0 Td
(short)Tj
2.4024 0 Td
(sleep)Tj
2.5654 0 Td
(duration)Tj
3.763 0 Td
(are)Tj
1.637 0 Td
(associated)Tj
4.9181 0 Td
(with)Tj
1.9631 0 Td
(lower)Tj
2.5653 0 Td
(serum)Tj
2.9552 0 Td
(vitamin)Tj
3.3307 0 Td
(D)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01809)Tj
4.089 0 Td
(01)Tj
0 g
2.0906 0 Td
(July)Tj
1.9701 0 Td
(7,)Tj
1.0417 0 Td
(2017)Tj
35.894 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(11)Tj
ET
Q
q
0.83 0.64 0.02 0 k
1 j
1 J
0 w
36 707.6409 m
156.0756 707.6409 l
h
f*
36 696.6425 m
161.4047 696.6425 l
h
f*
36 685.6441 m
168.3213 685.6441 l
h
f*
36 674.6457 m
183.7417 674.6457 l
h
f*
36 663.6472 m
87.9874 663.6472 l
h
f*
7.9999 0 0 7.9999 36 708.7181 cm
BT
/F9 1 Tf
1 TL
-0.025 Tc
0 0 Td
(detailed_with_)Tj
5.3575 0 Td
(publications&i)Tj
5.3008 0 Td
(ndex=&q2)Tj
3.8481 0 Td
(=)Tj
-14.5064 -1.3748 Td
(&selected_fa)Tj
4.8189 0 Td
(cets=pesquis)Tj
4.8685 0 Td
(adores_exac)Tj
4.6772 0 Td
(t:%)Tj
-14.3646 -1.3748 Td
(22Camila%)Tj
4.259 0 Td
(20Hirotsu%)Tj
4.4646 0 Td
(22&sort=-da)Tj
4.7198 0 Td
(ta_inicio)Tj
0 g
(;)Tj
0.83 0.64 0.02 0 k
-13.4434 -1.3748 Td
(http://www)Tj
4.1102 0 Td
(.bv.fapesp.)Tj
4.0323 0 Td
(br/pt/auxilios)Tj
4.8119 0 Td
(/29301/center)Tj
5.1803 0 Td
(-)Tj
-18.1347 -1.3748 Td
(for-sleep-)Tj
3.5787 0 Td
(studies/)Tj
0 g
(\))Tj
3.4441 0 Td
(Associac)Tj
0 Tc
2.941 0 Td
()Tj
/F10 1 Tf
-0.025 Tc
0.3614 0 Td
[( m)]TJ
/F9 1 Tf
(o)Tj
1.1126 0 Td
(Fundo)Tj
2.5371 0 Td
(de)Tj
1.1126 0 Td
(Incentivo)Tj
/F10 1 Tf
-15.0875 -1.3748 Td
[( j)]TJ
/F9 1 Tf
0.6448 0 Td
(Pesqui)Tj
2.5016 0 Td
(sa)Tj
1.063 0 Td
(\(AFIP\))Tj
2.5654 0 Td
(is)Tj
0.8362 0 Td
(a)Tj
0.6378 0 Td
(private)Tj
2.7142 0 Td
(philanthrop)Tj
4.2095 0 Td
(ic)Tj
0.8362 0 Td
(non-)Tj
-16.0087 -1.3748 Td
(profitable)Tj
3.685 0 Td
(organization)Tj
4.741 0 Td
(that)Tj
1.6228 0 Td
(has)Tj
1.5379 0 Td
(purchased)Tj
4.1102 0 Td
(reagents)Tj
-15.6969 -1.3748 Td
(for)Tj
1.2543 0 Td
(the)Tj
1.3748 0 Td
(performa)Tj
3.4087 0 Td
(nce)Tj
1.5378 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
1.3677 0 Td
(study.)Tj
2.4945 0 Td
(The)Tj
1.5875 0 Td
(sponsors)Tj
-13.9749 -1.3749 Td
(had)Tj
1.5874 0 Td
(no)Tj
1.1693 0 Td
(role)Tj
1.6157 0 Td
(in)Tj
0.8859 0 Td
(the)Tj
1.3677 0 Td
(study)Tj
2.2677 0 Td
(design,)Tj
2.8985 0 Td
(data)Tj
1.7929 0 Td
(collection)Tj
3.515 0 Td
(,)Tj
0.4464 0 Td
(and)Tj
-17.5465 -1.3748 Td
(analysis,)Tj
3.4086 0 Td
(or)Tj
1.0063 0 Td
(in)Tj
0.8859 0 Td
(the)Tj
1.3677 0 Td
(manuscript)Tj
4.415 0 Td
(writing.)Tj
/F8 1 Tf
-11.0835 -2.126 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F9 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(have)Tj
1.963 0 Td
(declared)Tj
-14.7827 -1.3748 Td
(that)Tj
1.6228 0 Td
(no)Tj
1.1693 0 Td
(competing)Tj
4.1599 0 Td
(interests)Tj
ET
endstream
endobj
46 0 obj
<>stream
endstream
endobj
47 0 obj
<>stream
endstream
endobj
48 0 obj
<>stream
endstream
endobj
49 0 obj
<>stream
endstream
endobj
50 0 obj
<>stream
endstream
endobj
51 0 obj
<>stream
endstream
endobj
52 0 obj
<>stream
endstream
endobj
53 0 obj
<>stream
endstream
endobj
54 0 obj
<>stream
endstream
endobj
55 0 obj
<>stream
endstream
endobj
56 0 obj
<>stream
endstream
endobj
57 0 obj
<>stream
endstream
endobj
58 0 obj
<>stream
endstream
endobj
59 0 obj
<>stream
endstream
endobj
60 0 obj
<>stream
endstream
endobj
61 0 obj
<>stream
endstream
endobj
62 0 obj
<>stream
endstream
endobj
63 0 obj
<>stream
endstream
endobj
64 0 obj
<>stream
BT
10.3394 -15.8741 Td
(exist.)Tj
ET
Q
endstream
endobj
65 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 70 0 R/Contents 71 0 R/TrimBox[0 0 612 792]>>
endobj
69 0 obj
<>
endobj
72 0 obj
<>
endobj
73 0 obj
<>stream
%!PS-AdobeFont-1.0
11 dict begin
/FontName /PI_chars_3 def
/FontType 1 def
/FontBBox {-11 -345 1373 718} readonly def
/FontMatrix [0.001 0 0 0.001 0 0] readonly def
/PaintType 0 def
/FontInfo 8 dict dup begin
/FullName (PI_chars_3) readonly def
/BaseFontName (PI_chars_3) def
end def
/Encoding 256 array
0 1 255 {1 index exch /.notdef put} for
dup 33 /exclam put
dup 34 /quotedbl put
dup 35 /numbersign put
dup 36 /dollar put
dup 37 /percent put
dup 38 /ampersand put
dup 39 /quoteright put
dup 40 /parenleft put
dup 41 /parenright put
dup 42 /asterisk put
dup 43 /plus put
dup 44 /comma put
dup 45 /hyphen put
dup 46 /period put
dup 47 /slash put
dup 49 /one put
dup 50 /two put
dup 51 /three put
dup 52 /four put
dup 53 /five put
dup 54 /six put
dup 55 /seven put
dup 56 /eight put
dup 58 /colon put
dup 60 /less put
dup 61 /equal put
dup 62 /greater put
dup 63 /question put
dup 64 /at put
dup 65 /A put
dup 66 /B put
dup 67 /C put
dup 68 /D put
dup 69 /E put
dup 70 /F put
dup 71 /G put
dup 72 /H put
dup 73 /I put
dup 74 /J put
dup 75 /K put
dup 76 /L put
dup 77 /M put
dup 78 /N put
dup 79 /O put
dup 80 /P put
dup 81 /Q put
dup 82 /R put
dup 83 /S put
dup 84 /T put
dup 85 /U put
dup 86 /V put
dup 87 /W put
dup 88 /X put
dup 89 /Y put
dup 90 /Z put
dup 91 /bracketleft put
dup 92 /backslash put
dup 93 /bracketright put
dup 94 /asciicircum put
dup 97 /a put
dup 98 /b put
dup 99 /c put
dup 100 /d put
dup 101 /e put
dup 102 /f put
dup 103 /g put
dup 104 /h put
dup 105 /i put
dup 106 /j put
dup 107 /k put
dup 108 /l put
dup 109 /m put
dup 110 /n put
dup 111 /o put
dup 112 /p put
dup 113 /q put
dup 114 /r put
dup 115 /s put
dup 116 /t put
dup 117 /u put
dup 118 /v put
dup 119 /w put
dup 120 /x put
dup 121 /y put
dup 122 /z put
dup 123 /braceleft put
dup 124 /bar put
dup 125 /braceright put
dup 126 /asciitilde put
readonly def
currentdict end
currentfile eexec
M#1H5 J6o\&rtS(#v\0\V7Fe༙OYx5-cY9^%Y6
(efIOldN"wȰ;)UƽoFg/rvV$JS8_oc@
o9-eGJp}[Do]mN=4*{ܯq=eU^t6¤/{zM4aܪ
Q:д'B-r^ܦ6y?rRnu S\U{Oλrs(Βƚ
#d29%s'ƈT1F8&\0Xd&&Zug'VPd]:>u=Q,?#(CV4'..|ӱ5 h
sȀg)fɘ`UXK^>] q\l#5pE"JO}rquáQBr/E7
QW5\GSlu{7ZH(PSf/O;̟w{ɴ}-K hA8!b!U>`#u?Vlnǝ19V+mg'QmA}S Y$í8n uJ ڒx3>[x0Z]
ͩw4M&1+pkC,sr"%q&OjbH{:5$65*S`cr;%s4Oӆe>T+6~pBOD!$c]"~r#nh6$38i˞[~Z}}rHmte9(1½=j{<\ ;? RA?c{Rf1'VԞ_-Lwo]`.l|zjf"![G1BYro˓9[-+z g!}RN+pX!M~HcFh@g%J6B)6!Lq>TX\ݪGF
PiQݓX~Fs;Ölo4/(C?+,ɖxۼ:xU^)
fd,`*>-:}=q$:\Xzcw1Nf(
ZkEeJXfэi@zXc\{a5qKg\5ݩv\Qe%1>OY̗$Y#P[)."^+{"bP]Bt&zeN6
іijDE% 0;̅
~~lfB>u'i4znym%tfԟ^נBTDS6-ghiWk/(r!!˶fc>趕%U