Worrisome New Evidence That Vaccines Are Less Effective Against Variants
Worrisome New Evidence That COVID-19 Vaccines Are Less Effective Against New Coronavirus Variants SciTech Daily - March 6
In animal tests: "two variants required from 3.5 to 10 times as much antibody for neutralization"
Reporting on
Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies
Nature Medicine, March 3, 2021 📄 PDF
Scientists underestimated the coronavirus — and are racing to keep up with evolution Washington Post March 7
Describes how the E484 mutation was predicted by two different groups before the mutation was found in the field
Refers to; Comprehensive mapping of mutations to the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human serum antibodies preprint Jan 2, 2021 📄 PDF
Also: Virus is able to have Mutations due to deletions in its RNA - deletions are not checked by the RNA proofreader
Other Predictions of E484
- Identification of twenty-five mutations in surface glycoprotein (Spike) of SARS-CoV-2 among Indian isolates and their impact on protein dynamics Sept 2020 📄 Download the PDF from VitaminDWiki