Vitamin D toothbrush, chewing gum, oral spray, oral health, etc. - many studies

Created July 2025

Overview of vitamin D, toothpaste, etc. Perplexity AI July 2025

Investigative Studies on Vitamin D Toothpaste

A notable study by Lee and Lee (2023) investigated creating a vitamin D delivery toothpaste using penetration enhancers 1. The researchers developed an emulsion-based toothpaste mixed with azone compound and sodium dodecyl sulfate as penetration enhancers, combined with vitamin D3 1. Their study demonstrated high feasibility for intraoral delivery of vitamin D through multiple characteristic tests, including abrasiveness, scratchiness, spreadability, pH, foaming, and antibacterial strength 1.

Another study formulated a vitamin D toothpaste using polysorbate 80 and dimethyl sulfoxide ( DMSO ) as penetration enhancers 2. This research aimed to formulate a toothpaste for delivering vitamin D into the bloodstream intraorally to address widespread vitamin D deficiency 2. The study used transepithelial electrical resistance (TEER) measurements to examine the feasibility of vitamin D transport through oral tissues 2.

Commercial Vitamin D Toothpaste Products

Several commercial vitamin D toothpaste products have been developed:

Better & Better Fortify Toothpaste : This product combines hydroxyapatite with vitamin D3 and calcium, containing 64mg of calcium and 8 mcg of vitamin D3 per brush 3.
Duo Vitamin D Toothpaste Tablets : These tablets feature daily doses of vitamins D3 (30mcg) and B12 (6mcg), absorbed through mucosal absorption while brushing 4.

Buccal Spray Research

Multiple studies have investigated vitamin D buccal spray delivery, which is similar to the concept of vitamin D toothpaste. Research by Penagini et al. (2021) demonstrated that vitamin D3 supplementation with buccal spray and oral drops was equally effective in raising vitamin D concentrations in short-term treatment 5. The study found that buccal spray delivery resulted in fine micro-sized droplets being quickly absorbed through the buccal mucosa into capillaries 6

Chewing Gum Studies

Research has explored vitamin D delivery through chewing gum, which provides insights into oral mucosal absorption. A Penn State study found that vitamin-supplemented chewing gum can increase salivary and plasma levels of vitamins, with vitamin D being absorbed through the oral mucosa 7 8. This research validated the concept of gum as an effective delivery system for vitamins 7.

Fluoride and Vitamin D Combinations__

Studies have examined the combined effects of fluoride and vitamin D on dental health. Research by Fiore et al. (2023) evaluated the application of a fluoride-and-vitamin D solution to deciduous teeth, finding that topical application promoted the formation of persistent mineral crystals on enamel surfaces 9.

Dental Caries Prevention

A comprehensive meta-analysis by Hujoel (2013) examining 24 controlled clinical trials with 2,827 children found that vitamin D supplementation had a pooled relative-rate estimate of 0.53 for caries prevention, suggesting a 47% reduction in caries risk 10. Another systematic review found that vitamin D supplementation was associated with reduced dental caries risk 11.

Periodontal Health

Research has consistently shown connections between vitamin D levels and periodontal health. Studies indicate that vitamin D deficiency is associated with increased severity of periodontal disease 12. Vitamin D supplementation has been shown to reduce inflammation and support periodontal healing 13.

Tooth Remineralization

Studies have demonstrated that oral vitamin D3 has significant potential in motivating remineralization of early lesions on enamel surfaces, improving surface microhardness and mineral content 14.

Lack of Research on Vitamin D Toothpicks

Despite extensive searching, I found no studies, comments, or research specifically examining vitamin D toothpicks. The research has focused primarily on toothpaste formulations, sprays, chewing gum, and other oral delivery methods, but toothpicks as a vitamin D delivery mechanism have not been investigated in the scientific literature.

Conclusion

While there is substantial research on vitamin D toothpaste formulations and various oral delivery methods for vitamin D, including buccal sprays and chewing gum, there appears to be no published research on vitamin D toothpicks. The existing studies on vitamin D toothpaste show promising results for intraoral delivery, with researchers successfully developing formulations that can deliver vitamin D through the oral mucosa. However, more clinical trials are needed to fully establish the effectiveness and safety of these delivery methods in humans.

References

Related in VitminDWiki

Some Dental studies

Vitamin D cut dental caries in half in 1930's – RCT meta-analysis
Caries (tooth decay) and Vitamin D - 23+ studies
Dental Implants helped by Vitamin D - many studies
Periodontitis reduced by Vitamin D - many studies
Vitamin D sprayed inside cheeks (buccal spray) - several studies
Topical Vitamin D provides more benefits than oral sometimes - many studies
- Topical can easily provide 100X more vitamin D yo skin or mouth than oral Vitamin D
Transcutaneous enhancers (DMSO, etc) for Vitamin D, Vitamin C, Resveratrol, Magnesium, etc.

Tags: Dental