Vitamin D Receptor affects 10 other genes
By Perplexity AI June 2024
The Vitamin D Receptor (VDR) affects the expression and regulation of numerous genes across the genome. Here are some key genes and gene families influenced by VDR:
CYP24A1: This gene encodes the enzyme responsible for vitamin D catabolism. VDR strongly upregulates CYP24A1 expression as part of a negative feedback loop to control vitamin D levels.
CAMP (Cathelicidin Antimicrobial Peptide): VDR induces expression of this gene, which plays a crucial role in innate immunity and antimicrobial defense.
Calcium transport genes: VDR regulates genes involved in calcium homeostasis, including calcium-binding proteins like calbindin, [Lung Cancer risk increases if low Vitamin D, poor activation of Vitamin D Receptor which affects the CALB1 gene – June 2024] and calcium channel proteins.
Bone metabolism genes: VDR influences genes involved in bone formation and resorption, such as osteocalcin (BGLAP) and osteopontin (SPP1).
Cell cycle regulators: VDR can modulate the expression of genes involved in cell proliferation and differentiation, including p21 and p27.
Immune system genes: VDR affects various genes involved in immune function, including cytokines and their receptors.
Renin-angiotensin system genes: VDR has been shown to regulate renin gene expression, influencing blood pressure control .
Detoxification genes: VDR regulates genes involved in xenobiotic metabolism, such as CYP3A4 .
Epigenetic modifiers: VDR can influence the expression of genes involved in epigenetic regulation , potentially affecting a wide range of cellular processes.
Tumor suppressor genes: In some contexts, VDR can regulate genes involved in cancer prevention and progression.
It's important to note that the specific genes affected by VDR can vary depending on cell type, tissue context, and physiological conditions.
The VDR is estimated to regulate about 3-5% of the human genome , potentially influencing thousands of genes directly or indirectly.
The complex interplay between VDR, its target genes, and various environmental and genetic factors contributes to the wide-ranging effects of vitamin D in the body
Perplexity provides many references
VitaminDWiki – Vitamin D Receptor contains
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