Vitamin D deficiency promotes intracranial aneurysm rupture (mice)

Vitamin D deficiency promotes intracranial aneurysm rupture

J Cereb Blood Flow Metab. 2024 Jul;44(7):1174-1183. doi: 10.1177/0271678X241226750

Tetsuro Kimura 1, Redi Rahmani 1 2, Takeshi Miyamoto 1, Yoshinobu Kamio 1, Daisuke Kudo 1, Hiroki Sato 1, Taichi Ikedo 1, Jacob F Baranoski 3, Hiroki Uchikawa 1, Jinglu Ai 1, Michael T Lawton 1 3, Tomoki Hashimoto 1

Far more rupture deaths in mice on low vitamin D diet

Intracranial aneurysm rupture causes severe disability and high mortality. Epidemiological studies show a strong association between decreased vitamin D levels and an increase in aneurysm rupture. However, the causality and mechanism remain largely unknown. In this study, we tested whether vitamin D deficiency promotes aneurysm rupture and examined the underlying mechanism for the protective role of vitamin D against the development of aneurysm rupture utilizing a mouse model of intracranial aneurysm.

Mice consuming a vitamin D-deficient diet had a higher rupture rate than mice with a regular diet. Vitamin D deficiency increased proinflammatory cytokines in the cerebral arteries. Concurrently, vitamin D receptor knockout mice had a higher rupture rate than the corresponding wild-type littermates. The vitamin D receptors on endothelial and vascular smooth muscle cells, but not on hematopoietic cells, mediated the effect of aneurysm rupture. Our results establish that vitamin D protects against the development of aneurysmal rupture through the vitamin D receptors on vascular endothelial and smooth muscle cells. Vitamin D supplementation may be a viable pharmacologic therapy for preventing aneurysm rupture.

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Note: Intracranial aneurysm rupture is somewhat similar but different from a Hemorrhagic Stroke

Example: Only 50% of the incidence, but far more deadly

Details at Perplexity AI

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VitaminDWiki – Stroke category contains

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