Type 1 Diabetes association with poor Vitamin D Receptor: 39 studies

Created April 2017

Inherited Variation in Vitamin D Genes and Type 1 Diabetes Predisposition

Genes 2017, 8(4), 125; doi:10.3390/genes8040125 (registering DOI)

* Vitamin D tests do not detect poor Vitamin D Receptor and 4 other classes of vitamin D genes. * Thus, you can have a good blood level of vitamin D but get T1 Diabetes and many other health problems because genes limit the amount of vitamin D getting to the cells * Health problems that run in families are often associated with low vitamin D - and genes decreasing Vitamin D getting to cells * Type 1 Diabetes prevention with Vitamin D and Omega-3 – Symposium April 2019 1. Pages listed in BOTH of the categories Diabetes and Vitamin D Receptor {category} 1. Vitamin D Receptor category has the following {include}

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Marissa Penna-Martinez and Klaus Badenhoop

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine 1, University Hospital Frankfurt, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany

(This article belongs to the Special Issue Genetics and Functional Genomics of Diabetes Mellitus)

The etiology and pathophysiology of type 1 diabetes remain largely elusive with no established concepts for a causal therapy. Efforts to clarify genetic susceptibility and screening for environmental factors have identified the vitamin D system as a contributory pathway that is potentially correctable. This review aims at compiling all genetic studies addressing the vitamin D system in type 1 diabetes. Herein, association studies with case control cohorts are presented as well as family investigations with transmission tests, meta-analyses and intervention trials. Additionally, rare examples of inborn errors of vitamin D metabolism manifesting with type 1 diabetes and their immune status are discussed.

We find a majority of association studies confirming a predisposing role for vitamin D receptor (VDR) polymorphisms and those of the vitamin D metabolism, particularly the CYP27B1 gene encoding the main enzyme for vitamin D activation. Associations, however, are tenuous in relation to the ethnic background of the studied populations. Intervention trials identify the specific requirements of adequate vitamin D doses to achieve vitamin D sufficiency. Preliminary evidence suggests that doses may need to be individualized in order to achieve target effects due to pharmacogenomic variation.

Tags: Diabetes Vit D Receptor