The vitamin D receptor (publisher wants 10 dollars for this update)

The vitamin D receptor: contemporary genomic approaches reveal new basic and translational insights

J Clin Invest. First published February 27, 2017 doi:10.1172/JCI88887.

J. Wesley Pike, Mark B. Meyer, Seong-Min Lee, Melda Onal, and Nancy A. Benkusky

The vitamin D receptor (VDR) is the single known regulatory mediator of hormonal 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] in higher vertebrates.

It acts in the nucleus of vitamin D target cells to regulate the expression of genes whose products control diverse, cell type–specific biological functions that include mineral homeostasis.

In this Review we describe progress that has been made in

• defining new cellular sites of action of this receptor,

• the mechanisms through which this mediator controls the expression of genes,

• the biology that ensues, and the

• translational impact of this receptor on human health and disease.

We conclude with a brief discussion of what comes next in understanding vitamin D biology and the mechanisms that underlie its actions.

Publisher wants $10 for the study or $25 for all articles for a day