Some seniors do not repond to 1600 IU of vitamin D
Half of seniors did not respond to 1600 IU of vitamin D daily for a year
RED square = reduction in serum level

from slide presentation: https://www.VitaminDWiki.com/tiki-index.php?page_id=2269
Possible reasons for non-response include, but are not limited to, the following
Lacking co-factors Magnesium, etc.
Surgery or other trauma during the year decreased vitamin D levels
Taking drugs such as Statins, Antiseizure, Prednisone, Orlistat, Questran, Dilatin, Phenobarbital, and Rifampin,
Non-alcoholic Fatty Liver Disease (4 in 10 seniors) and Vitamin D
Poor kidney function or poor endocrine function – to make the active form of vitamin D