Skin inflamation is often associated with low vitamin D - Dec 2025
Vitamin D in Patients with Inflammatory Skin Diseases
Acta clinica Croatica , Vol. 64. No. 1 , 2025. https://doi.org/10.20471/acc.2025.64.01.13
In search for the ways to cure and improve skin condition of patients with inflammatory skin diseases, vitamin D supplementation has been shown to be useful, primarily due to its effects on a number of skin functions, eg,
keratinocyte proliferation, differentiation and apoptosis,
maintenance of the epidermal barrier, and
regulation of immune processes in the skin, among others.
Vitamin D is essential for good general health and healthy skin, but deficiency can occur due to various factors that result in increased time spent indoors and limited sunlight exposure, such as geography (place of residence) and genetic factors.
Although some results are inconsistent, previous research indicates that multiple inflammatory skin diseases can be affected by vitamin D deficiency, particularly atopic dermatitis, but also other inflammatory skin diseases. There is also evidence for an association between vitamin D deficiency and the risk of worsening of skin diseases such as psoriasis, chronic urticaria, contact dermatitis, etc. For these and several other inflammatory skin diseases, most research suggests that patients benefit from vitamin D supplementation.
Skin Inflammation Diseases from Perplexity AI Dec 2025
| Rank | Disease | Global Prevalence | Key Statistics |
|---|---|---|---|
| 1 | Acne Vulgaris | ~9.4–20.5% | Up to 50 million Americans affected annually; 184.3 million prevalent cases globally among adolescents/young adults (2021)[^2][^3][^4][^5] |
| 2 | Atopic Dermatitis (Eczema) | 10–20% children; 2–10% adults | 223 million people worldwide; 31.6 million in the U.S.; ranks #1 among skin diseases for disability burden[^6][^7][^8][^9] |
| 3 | Seborrheic Dermatitis | ~4.4–5% | Global pooled prevalence of 4.38%; higher in adults (5.64%) than children; dandruff variant affects ~50% of population[^6][^10][^11][^12] |
| 4 | Rosacea | ~5–5.5% | Over 16 million Americans affected; highest in adults aged 45–60 years; more common in fair-skinned individuals[^13][^14][^15] |
| 5 | Contact Dermatitis | ~1.4–2.7% (hands); 13.6/1,000 population | Fifth most prevalent skin disease in U.S.; more common in females; increases with age[^16][^17][^18] |
| 6 | Psoriasis | 2–3% | 125 million people worldwide; 8 million+ in U.S.; 30% develop psoriatic arthritis[^19][^20][^21] |
| 7 | Urticaria (Hives) | ~0.9–1.4% (chronic) | 86 million prevalent cases globally (2017); lifetime prevalence up to 8.8%[^22][^23][^24] |
| 8 | Hidradenitis Suppurativa | 0.99–2.5% | Recent analyses suggest higher prevalence than previously estimated; more common in females; prevalence varies widely by region (0.03–4.1%)[^25][^26][^27][^28] |
| 9 | Lichen Planus | 0.2–1% (cutaneous); ~1% (oral) | Global oral LP prevalence of 0.89–1.01%; more common in women and adults over 40 years[^29][^30][^31][^32] |
| 10 | Vitiligo | 0.4–1.3% | 43.6 million people globally; lifetime risk of 0.92%; higher incidence in Asian populations[^33][^34][^35][^36] |
Related in VitaminDWiki
- Atopic Dermatitis and Eczema - many studies
- Eczema (Atopic Dermatitis) treated by 1,600 IU Vitamin D (again) – Meta-analysis 2019
- Those with Psoriasis were 7X more likely to have 20-30 ng levels of Vitamin D
- Psoriasis – less frequent and shorter duration with higher vitamin D (45 ng is nice)
- Psoriasis paradigm shift – use topicals, like Vitamin D
- Hives (Urticaria) 7X more likely if vitamin D deficient, supplementation helps – meta-analysis
- Psoriasis and Eczema Respond Well to Vitamin D Treatment (India) - Renu Oct 2023