Schizophrenia with high cRP is 4X less likely if high vitamin D

High levels of vitamin D in relation to reduced risk of schizophrenia with elevated C-reactive protein.

Psychiatry Res. 2015 Jun 10. pii: S0165-1781(15)00338-8. doi: 10.1016/j.psychres.2015.05.051. [Epub ahead of print]

Zhu DM1, Liu Y1, Zhang AG1, Chu ZX1, Wu Q1, Li H1, Ge JF2, Dong Y1, Zhu P3.

There is growing evidence on the novel role of vitamin D in reducing inflammation. This study aimed to examine the hypothesis that vitamin D is inversely associated with C-reactive protein (CRP) in patients with schizophrenia, and high levels of vitamin D may be linked to reduced risk of schizophrenia with elevated CRP. Ninety-three patients with schizophrenia and 93 family-matched controls were recruited in this cross-sectional study. Plasma concentrations of CRP and 25-hydroxyvitamin D [25(OH)D] were measured using commercial kits. Information about demographic characteristics and clinic data were obtained by interviews or medical records.

Mean levels of CRP and 25(OH)D were 43.3% higher and 26.7% lower for patients compared to controls, respectively. 25(OH)D were inversely associated with CRP in the patients, but not in the controls. The proportions of patients significantly increased with increasing quartiles of CRP, while significantly decreased with increasing quartiles of 25(OH)D. Among individuals with high CRP, participants with high 25(OH)D have significantly lower proportion (adjusted OR = 0.217 , 95% CI 0.063, 0.751) of schizophrenia compared to those with low 25(OH)D. The evidence suggested that high levels of vitamin D may be linked to reduced risk of schizophrenia with elevated CRP.

Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

PMID: 26106052

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See also VitaminDWiki

• Overview Schizophrenia and Vitamin D contains the following summary

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See also Vitamin D Council

• Vitamin D, inflammation and schizophrenia: What’s the relationship? July 2015
  • ” Participants with both high C-reactive protein and low vitamin D status had the highest proportion of schizophrenia. Those with high C-reactive protein levels and low vitamin D status had 36.01 increased odds of having schizophrenia compared to those with low C-reactive protein levels and high vitamin D status.”
  • . . . “low vitamin D levels may contribute to the development of schizophrenia, or low vitamin D status may be merely a result of staying indoors more”