RNA may also control Vitamin D metabolism (cancers, etc)

Vitamin D regulation of and by long non coding RNAs

Molecular and Cellular Endocrinology. https://doi.org/10.1016/j.mce.2021.111317

Daniel D.Bikle12

Highlights

1.LncRNAs and VDR each regulate numerous biochemical and genomic processes

2.Deletion of VDR shifts lncRNA expression to an oncogenic profile

3.Some lncRNAs can alter VDR expression or transcriptional activity

4.Different cancers show distinct VDR/lncRNA interactions and associations

VitaminDWiki bought the PDF - but cannot post it online Wonder how much of the variation of Vitamin D response and benefit is due to changes in RNA. See also: * Vitamin D Suppresses Ovarian Cancer Growth and Invasion by Targeting Long Non-Coding RNA CCAT2 - March 2020 Free PDF * Vitamin D and the RNA transcriptome: more than mRNA regulation - May 2014 Free PDF * LncRNA: a new player in 1α, 25(OH)2 vitamin D3/VDR protection against skin cancer formation - Feb 2014 Daniel D. Bikle Free PDF * Vitamin D and Non-coding RNAs: New Insights into the Regulation of Breast Cancer - March 2021 https://doi.org/10.2174/1566524020666200712182137 behind $68 paywall

Two percent or less of the genome is used to transcribe mRNAs encoding proteins. Nearly all the remainder is utilized in transcribing non coding RNAs, the bulk of which are RNAs at least 200 base in length, long non coding RNAs (lncRNA) . Their number is estimated to be about 28,000, but only a small fraction of lncRNAs are well characterized. That said lncRNAs have been found to regulate a very diverse array of biochemical and genomic functions. One of the transcription factors found to be regulated by and to regulate lncRNA is the vitamin D receptor (VDR). Like lncRNAs VDR is involved in the regulation of numerous biochemical and genomic processes, so it is not surprising that there would be a number of interactions between lncRNAs and VDR in their diverse functions. However, the study of these interactions is in its infancy.

To date most attention has been paid to their interactions in cancer. Our own studies have focused on non melanoma skin cancers, keratinocyte carcinomas to be precise. Deletion of VDR from keratinocytes predisposes them to malignant transformation. Among a number of potential mechanisms we found that VDR deletion from these cells alters the lncRNA profile to a more oncogenic configuration, increasing the expression of well known oncogenic lncRNAsa and decreasing the expression of well known tumor suppressor lncRNAs. Subsequent studies in other cancers have found similar associations between VDR and oncogenic lncRNAs with evidence of tumor specificity. To date these studies primarily reveal associations rather than causality, but causal links should be expected as research in this field continues to develop.

Key words: vitamin D vitamin D receptor keratinocytes cancer long non coding RNA genomics

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Created May 2021