Risks of Colorectal Cancer, IBD, etc slightly increased if poor Vitamin D Receptor

Created December 2018

Vitamin D receptor FokI polymorphism and the risks of colorectal cancer, inflammatory bowel disease, and colorectal adenoma.

Sci Rep. 2018 Aug 27;8(1):12899. doi: 10.1038/s41598-018-31244-5.

Cho YA1, Lee J1, Oh JH2, Chang HJ2, Sohn DK2, Shin A3, Kim J4.

1 Dept of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, South Korea.

2 Center for Colorectal Cancer, National Cancer Center Hospital, National Cancer Center, Goyang, South Korea.

3 Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea.

4 Dept of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, South Korea. jskim@ncc.re.kr.

* Inflammatory Bowel Disease associated with low Vitamin D, low Zinc, and low Selenium – May 2017 * Inflammatory Bowel Disease and Vitamin D review (needs 40-50 ng) – Feb 2018 * Colorectal cancer is associated with Vitamin D (17 meta-analyses so far) – July 2018 * Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016 * * The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019** 1. VitaminDWiki - Vitamin D Receptor activation can be increased in many ways {include} --- 1. # Items in both categories Cancer- Colon and VDR are listed here: {category} --- 1. # Items in both categories Gut and VDR are listed here: {category} --- 1. # Items listed in BOTH the categories Colon Cancer and Genetics (other than VDR) are listed here {category} --- 1. Overview Gut and vitamin D contains gut-friendly information__ {include}

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Based on an inverse association between vitamin D levels and the risks of colorectal diseases, a functional start codon polymorphism in the vitamin D receptor (VDR) gene is speculated to affect the risks for these diseases. To validate this hypothesis, we first conducted a case-control study of 695 colorectal cancer patients and 1,397 controls. The association of VDR FokI polymorphism with colorectal cancer risk was analyzed using a logistic regression model. In the present case-control study, compared to the F allele, the f allele seemed to be associated with lower risks of colon cancer and advanced colorectal cancer. Additionally, a meta-analysis of 27 studies was conducted to combine findings from previous studies investigating the association of FokI polymorphism with colorectal disease using a random effects model. In the present meta-analysis, the f allele was positively associated with the risk of inflammatory bowel disease, including Crohn's disease and ulcerative colitis. However, this allele was inversely associated with colon cancer and was not associated with the risk of rectal cancer or colorectal adenoma. In conclusion, the findings from this study imply that the role of VDR FokI polymorphism may differ based on the type and severity of colorectal disease.

Tags: Colon Cancer Vit D Receptor