Effective Topical Agents and Emerging Perspectives in the Treatment of Psoriasis

Andrea Chiricozzi; Sergio Chimenti

Expert Rev Dermatol. 2012;7(3):283-293. © 2012 Expert Reviews Ltd.

Psoriasis is one of the most common inflammatory skin diseases. The mild form of psoriasis is usually treated with topical medications and phototherapy, whereas conventional systemic therapies, including retinoids, cyclosporine and methotrexate, are used for the treatment of moderate-to-severe psoriasis. The therapeutic approach has been revolutionized over the past decade by the introduction of biologic agents or 'small molecules' that have been proven to have striking clinical efficacy. This review highlights the most effective topical antipsoriatic treatments, focusing on emerging promising topical drugs that are currently being tested in ongoing clinical trials.

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PDF Table of Contents

Abstract and Introduction

Psoriasis as a Complex Immune-mediated Disorder

Conventional Topical Agents

Corticosteroids

Vitamin D3 Derivatives

Combined Therapy With Vitamin D3 Derivatives & Corticosteroids

Retinoids

Tars & Anthralin

Keratolytics

Topical Calcineurin Inhibitors

New Perspectives for Topical Therapy

MEK1/MEKK1 Inhibitor

Other Nonsteroidal Anti-inflammatory Agents

Expert Commentary

Five-year View

References

Sidebar

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See also VitaminDWiki

• All items in category Psoriasis and Vitamin D items

• Psoriasis, metabolic syndrome, and vitamin D – 2011

• Psoriasis best treated by combinations such as vitamin D and UVB – meta-analysis Dec 2011

• Psorasis combination therapies usually include vitamin D – review Feb 2013

See also web

• Psoriasis random controlled trial starting in NZ in 2012
  • 100,000 IU vitamin D monthly for a year ( 3,300 IU daily, probably not enough)