Retinal venous occlusions (eye stroke) 133 X more likely if low vitamin D

Serum vitamin D levels in Indian patients with retinal venous occlusions.

Saudi J Ophthalmol. 2017 Apr-Jun;31(2):76-79. doi: 10.1016/j.sjopt.2017.03.005. Epub 2017 Mar 28.

Oli A, Joshi D, Eye Department Command Hospital, Bangalore 560007, India.

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PURPOSE:

To estimate serum vitamin D (25 OH D) level in patients of retinal vein occlusion (RVO) and compare it with age-matched controls.

METHODS AND MATERIAL:

Forty patients above 18 years of age with retinal vein occlusion and forty age-matched controls underwent serum vitamin D (Vit D) level estimation using a standard protocol. Student's t test was used to analyse differences between the mean of two groups.

RESULTS:

The mean age in RVO and control group was 60.25 and 60.73 years respectively. The mean (±SD) level of vitamin D in RVO patients was 13.68 (±4.58) ng/mL (range 5.5-24.8), and the 95% CI of mean was 12.21-15.14 with SD 4.58 while in control group it was 23.03 (±2.89) ng/ml (range 18.4-30.1) with 95% CI of mean being 22.11-23.96 with SD 2.89 (p value of <0.005). While comparing the level of Vitamin D based on type of occlusion the mean level of Vit D in CRVO patients was 15.36 (SD 5.30) and in BRVO it was 12.77 (SD 3.96) which was statistically not significant (p = 0.08). The odds ratio calculated for RVO cases versus controls was 133.33 which was statistically significant (P < 0.05).

CONCLUSIONS:

There is a paucity of published literature on level of Vit D in RVO. This study shows significantly lower levels of serum vitamin D in Indian patients with retinal vein occlusion as compared to age matched controls. Establishment of this correlation has possible implications for prophylaxis or treatment of RVOs.

PMID: 28559717 PMCID: PMC5436375 DOI: 10.1016/j.sjopt.2017.03.005

Two of the references

• Epstein, D., Kvanta, A., and Lindqvist, P.G. Vitamin D deficiency in patients with central retinal vein occlusion: a case control study. Curr Eye Res. 2017; 42: 448–451

• Talcott, K.E. and Eliott, D. Central retinal vein occlusion associated with severe vitamin D deficiency. Ophthal. Surg. Lasers Imag. Retina. 2016; 47: 372–375

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See also web

• 5 cases per 1000 of general population older than 64 years.

• Retinal Vein Occlusion (RVO) Medscape May 2017

  • "Retinal vein occlusion (RVO) is a common vascular disorder of the retina and one of the most common causes of vision loss worldwide. Specifically, it is the second most common cause of blindness from retinal vascular disease after diabetic retinopathy."