Pulmonary Tuberculosis 2X more likely if poor Vitamin D Receptor (Mexico)

Created April 2018

Association between Vitamin D receptor gene polymorphisms and pulmonary tuberculosis in a Mexican population

Indian Journal of Tuberculosis, online 13 April 2018, https://doi.org/10.1016/j.ijtb.2018.04.005

Beatriz Silva-Ramíreza, , , Cyntia A. Saenz-Saenza, Leonardo A. Bracho-Velaa, Katia Peñuelas-Urquidesb, Viviana Mata-Tijerinac, Brenda L. Escobedo-Guajardoc, Nelly R. González-Ríosc,

Note: 29.6% of Mexican TB patients had the poor VDR gene * Million TB deaths annually, yet proven treatments of Vitamin D, sunshine, etc are not used – July 2017 * Tuberculosis recovery speeded up by single 450,000 IU dose of vitamin D – RCT Jan 2017 * Low vitamin D is a risk factor for tuberculosis – meta-analysis Dec 2016 * Tuberculosis -100 percent cure rate with 10,000 IU of vitamin D daily – RCT 2006 * Tuberculosis, genes and vitamin D – Meta-Analysis Dec 2013 * More TB-related genes than just the Vitamin D Receptor Items in both categories TB and VDR are listed here: {category} --- 1. Vitamin D Receptor category has the following {include}

Highlights

• Genetic variations are relevant in modulating susceptibility to PTB.

• We studied the association between polymorphic VDR and PTB in a Mexican population.

• The CC genotype of FokI increased susceptibility to PTB.

Background and Aims

The impact of host genetic variation in susceptibility of tuberculosis is well documented. The Vitamin D receptor gene (VDR) is a transacting transcription factor which mediates innate immune response by enhancing the expression of several antimicrobial peptides, including cathelicidin. An association between VDR polymorphisms with tuberculosis (TB) has been investigated in different ethnic groups; however there are contradictions and inconsistencies in the results. The aim of this study was to evaluate the association between polymorphisms of functional VDR with the susceptibility to pulmonary tuberculosis in a Mexican population.

Methods

A case control study was performed in, 257 patients with pulmonary tuberculosis and 457 healthy controls recruited from: family medicine clinics of the Mexican Social Security Institute. The VDR gene polymorphisms Fok I (rs 2228570), BsmI (rs1544410), ApaI (rs7975232) and TaqI (rs731236) were genotyped by TaqMan assays. Statistical analysis was performed using: Epi Info V-7 and SNP Stats software.

Results

No statistically significant associations were observed in genotype and haplotype distribution between BsmI, ApaI and TaqI polymorphisms and disease susceptibility. The CC genotype for the VDR gene FokI was significantly more frequent in patients than in controls ( 29.6% versus 17.5%, OR = 1.97 ; 95% CI = 1.37-2.8, PC = 0.0004). Moreover, TT genotype was decreased in patients as compared to the control group (24.1% versus 34.8%, OR = 0.59; 95% CI = 0.42-0.84, PC = 0.004).

Conclusion

To our best knowledge, this is the first case-control study that finds an association between CC genotype of FokI SNP in the VDR gene with pulmonary tuberculosis in Mexican patients. However more validation studies should be performed to prove our conclusions.

Tags: Tuberculosis Vit D Receptor