Poor Vitamin D Receptor does not increase the risk of Breast Cancer (but the opposite is true) – umbrella meta-analysis

Association between vitamin D receptor polymorphism and breast cancer in women: An umbrella review of meta-analyses of observational investigations

Experimental Gerontology, September 2024, https://doi.org/10.1016/j.exger.2024.112502

Highlights

• This comprehensive review synthesizes evidence on VDR polymorphisms and breast cancer risk in women.

• Analysis includes 119 datasets from 17 meta-analyses on BsmI, 6 on Cdx2, and 6 on Poly (A) polymorphisms.

• Only 5 % of the analyzed datasets reported statistically significant associations.

• VDR polymorphisms (BsmI, Cdx-2, and Poly (A)) are not strongly linked to breast cancer risk.

This study aimed to conduct an umbrella review of meta-analyses to synthesize the existing evidence regarding the relationship between vitamin D receptor (VDR) polymorphism and breast cancer (BC) risk. A comprehensive search was performed across multiple databases, including Embase, PubMed, Scopus, the Cochrane Database of Systematic Reviews, and the Web of Science. The investigation included 17 meta-analyses for the BsmI polymorphism, 6 for the Cdx2 polymorphism, and 6 for the Poly (A) polymorphism. Among the 119 datasets analyzed, only 6 (5 %) reported statistically significant outcomes (p < 0.05), comprising 2 comparisons for VDR BsmI polymorphism (3 %), 1 for VDR Cdx-2 polymorphism (4 %), and 3 for VDR Poly (A) polymorphism (14 %), across various genetic models. Notably, significant heterogeneity was observed in 82 comparisons, and publication bias was detected in 16 comparisons. Furthermore, a substantial proportion (86 %) of the included studies exhibited critically low methodological quality.

In conclusion, our findings suggest that VDR polymorphism (BsmI, Cdx-2, and Poly (A)) is not strongly associated with BC risk in the general population.

📄 Download the PDF from VitaminDWiki

VitaminDWiki - studies in both categories Breast Cancer and Vitamin D Receptor

This list is automatically updated

{category}