Metabolic Syndrome 40 percent less likely in seniors with vitamin D

Created December 2014

Vitamin D status and metabolic syndrome in the elderly: the Rotterdam Study

European Society of Endocrinology, on-line December 2, 2014, doi: 10.1530/EJE-14-0580

Anna Vitezova, Carola Zillikens, Thijs van Herpt, Eric Sijbrands, Albert Hofman, Andre Uitterlinden, Oscar Franco and Jessica Kiefte-de Jong⇑

A Vitezova, Epidemiology, Erasmus MC, Rotterdam, 3000 CA, Netherlands

C Zillikens, Internal Medicine, Erasmus MC, Rotterdam, Netherlands

T van Herpt, Epidemiology, Erasmus MC, Rotterdam, Netherlands

E Sijbrands, Internal Medicine, Erasmus MC, Rotterdam, Netherlands

A Hofman, Epidemiology, Erasmus MC, Rotterdam, Netherlands

A Uitterlinden, Internal Medicine, Erasmus MC, Rotterdam, Netherlands

O Franco, Epidemiology, Erasmus MC, Rotterdam, Netherlands

J Kiefte-de Jong, Rotterdam, 3000CA, Netherlands j.c.kiefte-dejong@erasmusmc.nl

39% less likely if > 30 ng vitamin D compared to < 20 ng of vitamin D 3240 seniors who did not have diabetes at baseline - age 71 1. See also VitaminDWiki Overview Metabolic Syndrome and vitamin D   items * Overview Diabetes and vitamin D * Overview Obesity and Vitamin D * Metabolic Syndrome 13 percent more likely for every 10 ng less vitamin D – Meta-analysis Jan 2014 * Metabolic syndrome 1.9 X more likely if senior women had less than 30 ng of Vitamin D – Oct 2017 Items in both categories Metabolic Syndrome and Seniors are listed here: {category}

Objective: The effects of vitamin D in the elderly are inconsistent. The aim of this study was to evaluate the association between vitamin D status and the metabolic syndrome (MetS) in the elderly, as well as between vitamin D status and the components of MetS (i.e.

  • serum glucose,

  • triglycerides (TG),

  • HDL cholesterol (HDL-C),

  • waist circumference (WC), and

  • blood pressure (BP)).

Methods: The study was embedded in the Rotterdam Study, a population-based cohort of middle-aged and elderly adults.

We analyzed data from 3240 people (median age 71.2 years) who did not have type 2 diabetes mellitus at baseline.

Results: We found higher 25-hydroxyvitamin D (25(OH)D) concentrations associated with lower prevalence of MetS (Odds Ratio (OR); 95% Confidence Interval (CI): 0.61; 0.49, 0.77 for adequate levels (≥75nmol/l) versus deficiency (<50nmol/l) .

Additionally, in analysis of the individual components, the ORs for adequate versus deficient vitamin D levels were:

  • 0.66 (95%CI 0.53,0.83) for elevated WC,

  • 0.67 (95%CI 0.52,0.86) for reduced HDL-C,

  • 0.69 (95%CI 0.54,0.88) for elevated triglycerides,

  • 0.80 (95%CI 0.65,0.99) for elevated fasting glucose.

Vitamin D was not associated with elevated blood pressure, ORs for adequacy versus deficiency were 0.82 (95%CI 0.65,1.03).

Conclusion: Higher 25(OH)D concentrations in the elderly are associated with lower prevalence of MetS and, in particular, with more beneficial HDL-C, TG, WC and serum glucose. Since the prevalence of vitamin D deficiency is common worldwide and its risk increases with age, if causality is proven, benefits of improving vitamin D status among the elderly may be great.

Publisher wants $33 for the PDF

Tags: Metabolic Syndrome Seniors