Meniere's Disease (inner ear) treated by Vitamin D (50K weekly for 3 months)
Serum level of vitamin D and its relation to Meniere's disease
Egyptian Journal of Neck Surgery and Otorhinolaryngology 10.21608/ejnso.2024.244982.1086
Maha Ibrahim 1 Noha Elsherif 2 Mahmood Ahmed Hamed 2
1 Audiology and vestibular Unit, ORL Department, Sohag University Egypt
2 ORL department, Sohag University
Objectives; To determine the level of vitamin D in Patients with Meniere's disease (MD) and investigate the effect of its supplementation on the frequency and duration of MD attacks.
Patient and methods: A matched case/control study was conducted. Vitamin D serum level was estimated in patients with MD before and 3 months after its administration. The degree of improvement in frequency and duration of MD attacks was calculated.
Results; Our study included 112 persons (28 cases and 84 controls). Low serum levels of vitamin D were detected in MD patients. In addition, we found a significant statistical difference Dizziness Handicapped Inventory (DHI) Questionnaire before and after vitamin D supplementation (p<0.0001).
Conclusions: The current study found that MD patients had lower serum vitamin D levels. There appears to be a link between vitamin D and MD, and this study looked at a correlation rather than establishing causation. Also vitamin D supplementation has a beneficial role in controlling Meniere's disease symptoms and lowering frequency of occurrence of the disease.
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Meniere's Disease symptoms not treated by 50,000 IU vitamin D in 8 weeks - RCT 2025
The Effects of Vitamin D Supplementation on Vertigo and Tinnitus in Patients with Meniere's Disease: A Randomized Clinical Trial.
Journal of Reports in Pharmaceutical Sciences, 2025, v. 13, n. 1, p. 1, doi. 10.5812/jrps-158540
Talebi, Ali; Yazdani, Nasrin; Kasaeian, Amir; Talebi, Sepide; Mohebbi, Niayesh (IRAN)
Background: The present study aimed to evaluate the impact of vitamin D supplementation as an adjuvant therapy on tinnitus and vertigo in individuals diagnosed with Meniere's disease. Methods: The study was conducted from November 2021 to October 2022 at Tehran University Hospital, Tehran, Iran. This clinical trial involved 60 individuals diagnosed with Meniere's disease and vitamin D deficiency. Participants were randomly allocated to receive either vitamin D (50,000 IU weekly) or a placebo for eight weeks. The study assessed the frequency, intensity, and duration of vertigo attacks, as well as several measures of dizziness and tinnitus, both before and after the intervention.
Results: No significant change was observed in the number of vertigo attacks (P = 0.85), the duration (P = 0.52), or the severity of vertigo (P = 0.33) in the vitamin D group compared to the placebo group at the end of the trial. Additionally, vitamin D supplementation did not significantly affect the results of various dizziness and tinnitus indices at the study's conclusion (P > 0.05). As expected, serum levels of vitamin D were significantly higher in the intervention group compared to the placebo group at the trial's endpoint (P < 0.001).
Conclusions: Vitamin D supplementation did not significantly affect vertigo and tinnitus in patients with Meniere's disease. Further clinical trials with larger sample sizes and longer durations are recommended to confirm these findings.
Note: the Study in Egypt was successful with 3 month duration, vs this Iran trial lasted only 2 months
Vitamin D might treat Meniere's disease - Perplexity AI review of evidence - June 2025
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Glutathione may treat Meniere's disease 2 AI reviews June 2025
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