Low fertility associated with low Calcium intake and low vitamin D
Vitamin D deficiency among subfertile women: case control study.
Gynecol Endocrinol. 2015 Nov 16:1-18. [Epub ahead of print]
Al-Jaroudi D1,2, Al-Banyan N3, Aljohani NJ4,5,6, Kaddour O7, Al-Tannir M8.
1a Reproductive Endocrinology and Infertility, Minimally Invasive Gynecologic Surgery.
2b Reproductive Endocrinology and Infertility Medicine Department (REIMD), Women's Specialized Hospital, King Fahad Medical City , PO Box 59046 , Riyadh 11525.
3c Pharmacy Services Administration, King Fahad Medical City , PO Box 59046 , Riyadh 11525.
4d Faculty of Medicine , King Saud bin Abdulaziz University for Health Sciences , Riyadh 22490 , Saudi Arabia.
5e Specialized Diabetes and Endocrine Center, King Fahad Medical City , Riyadh 59046 , Saudi Arabia.
6f Prince Mutaib Chair for Biomarkers of Osteoporosis, College of Science, King Saud University , Riyadh 11451 , Saudi Arabia.
7g Research Center, King Fahad Medical City , Riyadh , Saudi Arabia.
8h Research Department , King Fahad Medical City , PO Box 59046 , Riyadh 11525.
The objective of the study is to compare the dietary vitamin D and calcium intake among subfertile women (cases) versus pregnant women (controls) and to determine the vitamin D levels in the subfertile and pregnant women. Study design was an observational case-control study where a total of 181 (83 previously diagnosed subfertile cases from various causes and 98 pregnant controls) women of reproductive age. A validated questionnaire was used where it focused on key indicators evaluating vitamin D related factors. Blood was withdrawn for the measurement of serum calcium, albumin and phosphate to exclude secondary causes that might affect Vitamin D level.
RESULTS:
The prevalence of vitamin D deficiency was significantly higher in the subfertile group than controls (59.0% versus 40.4%; p < 0.01). Calcium supplements intake was significantly higher in controls than the subfertile group (64.6% versus 10.0%; p-value < 0.001). Total dietary vitamin D intake (> 400IU/day) was significantly higher in the controls than the subfertile group.
CONCLUSIONS:
Vitamin D deficiency is prevalent among subfertile women. Optimization of serum calcium and vitamin D levels is encouraged.
PMID: 26573125