Less Parkinson’s Disease if more vitamin D

Vitamin D Status and Parkinson’s Disease

Brain Sci. 2022, 12(6), 790; https://doi.org/10.3390/brainsci12060790

by Michela Barichella 1,2,†,Federica Garrì 2,*,†,Serena Caronni 2,Carlotta Bolliri 2,Luciano Zocchi 3, Maria Carmela Macchione 2,Valentina Ferri 2,Daniela Calandrella 2 and Gianni Pezzoli 2

1 Parkinson Institute, ASST Gaetano Pini-CTO, 20126 Milan, Italy

2 Fondazione Grigioni per il Morbo di Parkinson, 20126 Milan, Italy

3 Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Sezione di Fisiologia, 20133 Milan, Italy

Study Table on Contents

Parkinson’s disease (PD) is a complex and progressive neurodegenerative disease, characterized by resting tremor, rigidity, slowness of movement, and postural instability. Furthermore, PD is associated with a wide spectrum of non-motor symptoms that add to overall disability. In recent years, some investigations, from basic science to clinical applications, have focused on the role of vitamin D in PD, often with controversial findings. Vitamin D has widespread effects on several biological processes in the central nervous system, including neurotransmission in dopaminergic neural circuits. Various studies have recorded lower levels of vitamin D in PD patients than in healthy controls. Low vitamin D status has also been correlated with the risk for PD and motor severity, whereas less is known about the effects vitamin D has on cognitive function and other non-motor symptoms. This review aims to better characterize the correlation between vitamin D and PD, clarify the role of vitamin D in PD prevention and treatment, and discuss avenues for future research in this field

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