Leprosy associated with changes to Vitamin D receptor genes (VDR)

Created April 2015

Association of Taq I, Fok I and Apa I polymorphisms in Vitamin D Receptor (VDR) gene with Leprosy.

Hum Immunol. 2015 Apr 15. pii: S0198-8859(15)00133-0. doi: 10.1016/j.humimm.2015.04.002. [Epub ahead of print]

Neela VS1, Suryadevara NC1, Shinde VG1, Pydi SS1, Jain S2, Singh SS3, Valluri VL1, Anandaraj MP1.

The strength of the association is not stated in the abstract Typical VDR associations with diseases are < 10% See also VitaminDWiki * 229 Genes related to vitamin D - Aug 2010 mentions Leprosy * Vitamin D, immunity and microbiome – Dec 2014 mentions Leprosy * Diseases, Vitamin D Receptor and other genes – June 2014 mentions Leprosy * 2X more Parkinson's disease if modified vitamin D receptor genes – meta-analysis Aug 2014 * Response to 1000 IU of vitamin D varies by about 4 percent due to gene variants – RCT July 2014 * Multiple Sclerosis and the Vitamin D Receptor – meta-analysis July 2014 * 2,776 vitamin D receptor binding sites - April 2014 * Leprosy 28 X more likely if a newly found Vitamin D Receptor modification (A61894G) – Dec 2017

BACKGROUND:

Vitamin D Receptor (VDR) is a transacting transcription factor which mediates immunomodulatory function and plays a key role in innate and adaptive immune responses through its ligand and polymorphisms in VDR gene may affect its regulatory function.

OBJECTIVE:

To investigate the association of three VDR gene polymorphisms (TaqI rs731236, FokI rs2228570 & ApaI rs7975232) with Leprosy.

METHODS:

The study group includes 404 participants of which 222 were leprosy patients (Paucibacillary=87, Multibacillary=135) and 182 healthy controls. Genotyping was done using PCR-RFLP technique. Statistical analysis was performed using SNP Stats & PLINK software.

RESULTS:

The VDR FokI (rs2228570) ff genotype, ApaI (rs7975232) AA, Aa genotype and haplotype T-f-a, T-F-A were positively associated with leprosy when compared to healthy controls.

CONCLUSION:

The two variants at Fok and Apa positions in VDR gene are significantly associated with leprosy. Genotypes at FokI (ff), ApaI (aa) and haplotype (T-F-a, T-f-a) may contribute to the risk of developing leprosy by altering VDR phenotype/levels subsequently modulation of immune response.

Copyright © 2015. Published by Elsevier Inc.

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PMID: 25890006

Tags: Vit D Receptor