Kidney Cancer 4X more likely if poor Vitamin D Binding Protein (5X in previous study)

Created October 2019

Vitamin D Binding Protein and Risk of Renal Cell Carcinoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO).

Int J Cancer. 2019 Oct 29. doi: 10.1002/ijc.32758

Kratzer TB1, Weinstein SJ2, Albanes D2, Mondul AM1.

1 Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI.

2 Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD.

* 5X less risk of Kidney cancer if good ratio of Vitamin D binding protein to circulating vitamin D – Nov 2013 * Vitamin D Binding Protein masks how much Vitamin D gets to tissues – May 2019 * Kidney cancer 22 percent less likely if high vitamin D – meta-analysis Nov 2015 * Classic thought was that Vitamin D level, not VDRP level was the important blood marker for Kidney Cancer Vitamin D Binding Protein category listing has items and the following introduction {include} Vitamin D Binding Protein has a list of health problems {include}

Our group has conducted two previous studies on the association between vitamin D binding protein (DBP) and renal cell carcinoma (RCC), the most common form of kidney cancer, finding strong inverse associations. We undertook the current analysis to replicate our findings in a different study population that included women and non-smokers. We conducted a nested case-control study in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO). Cases (n=323) were matched 1:1 to controls on age (+/- 1 year), race, date of blood collection (+/- 30 days) and sex. We performed conditional logistic regression to estimate the odds ratios and 95% confidence intervals for the association between quartiles of circulating DBP and risk of RCC.

We observed a statistically significant positive association between DBP and RCC that persisted after adjustment for history of diabetes, history of hypertension, family history of renal cancer, body mass index (BMI), and smoking status (mv-adj Q4 vs. Q1 OR= 4.1 , 95% CI=2.2-7.8; p-trend <0.0001).

These findings were similar when we restricted to cases with at least two years of follow-up and no major weight loss, suggesting that our findings are not due to reverse causality . In the present study, those with higher serum concentrations of DBP were at increased risk of RCC, in contrast to previously published findings. Further research is necessary to determine the true association between DBP and risk of RCC, and whether different DBP phenotypes may have different associations with risk of RCC.

Tags: Cancer - Other Vit D Binding Protein