High PSA readings with Prostate Cancer 4 times more likely if poor Vitamin D receptor

Created November 2016

Association of vitamin D receptor variants with clinical parameters in prostate cancer.

Springerplus. 2016 Mar 24;5:364. doi: 10.1186/s40064-016-2009-8. eCollection 2016.

Nunes SB1, de Matos Oliveira F2, Neves AF3, Araujo GR4, Marangoni K4, Goulart LR5, Araújo TG1.

Seems reasonable Low Vitamin D ==> high PSA readings Poor Vitamin D Receptor ==> less vitamin D getting to cells See also VitaminDWiki * 2X less prostate cancer in A-A with low Calcium is due vitamin D receptor gene – July 2013 * Radical Prostatectomy problems 2.6X more likely if low vitamin D – Feb 2016 1. Vitamin D Receptor category has the following {include}

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PURPOSE:

Prostate Cancer (PCa) is one of the most common cancers in men and its early detection can provide a high chance of cure. The detection of Vitamin D Receptor (VDR) gene polymorphisms may be useful as a molecular indicator of clinical outcome, once VDR is implicated in a wide variety of biological processes including modulation of the immune response and inhibition of cancer cell growth, angiogenesis and metastasis. In this study we explored the Single Nucleotide Polymorphisms (SNPs) FokI, BsmI, ApaI and TaqI, to evaluate the susceptibility locus for PCa and verify its correlation with clinical parameters.

METHODS:

VDR polymorphisms were detected by PCR followed by Restriction Fragment Length Polymorphism (PCR-RFLP). DNA samples were extracted from peripheral blood of 342 patients: 132 PCa, 41 Benign Prostatic Hyperplasia and 169 young healthy volunteers.

RESULTS:

Statistical analysis showed a noteworthy correlation among SNPs and clinical pathological features. CC genotype (TaqI) was correlated with the age at diagnosis (>58 years old), and GG (BsmI) was associated to lower Prostate-Specific Antigen (PSA) levels (<10 ng/mL). Moreover, when PCa patients were subgrouped, G allele (BsmI) significantly increased the estimated chance for PSA < 10 ng/mL, and GG/GG genotype (BsmI/ApaI) provided a 9.75 fold increased chance of patients with PCa to present lower PSA levels.

CONCLUSIONS:

The polymorphisms of VDR gene showed a genotype-phenotype association and presented new correlations with different parameters as age and PSA levels.

PMID: 27066374 PMCID: PMC4805678 DOI: 10.1186/s40064-016-2009-8

Tags: Prostate Cancer Vit D Receptor